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Defu Zhi, Baiyan Dai, Huaiyu Li, Ayinigeer Halemaimaiti, Haoran Wang, Xiaoran Na, Guangye Zhu, Shubiao Zhang. Multi-stimuli responsive microneedle systems for precision transdermal therapy[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101634
Citation: Defu Zhi, Baiyan Dai, Huaiyu Li, Ayinigeer Halemaimaiti, Haoran Wang, Xiaoran Na, Guangye Zhu, Shubiao Zhang. Multi-stimuli responsive microneedle systems for precision transdermal therapy[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101634
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Multi-stimuli responsive microneedle systems for precision transdermal therapy

doi: 10.1016/j.jpha.2026.101634

  • Key Laboratory of Biotechnology and Bioresources Utilization of Ministry of Education, College of Life Science, Dalian Minzu University, Dalian, Liaoning,116600 China

Funds:

This work was partially supported by National Natural Science Foundation of China (Grant No.: U23A20488), Key Research and Development Project of Liaoning Province (Grant Nos.: 2021JH/2/10300071, 2023JH2/101800011 and 2023JH2/101700075), and Science and Technology Innovation Fund of Dalian (Grant Nos.: 2023RJ005, 2023JJ11CG007 and 2022JJ12SN046)

  • Received Date: Oct. 08, 2025
  • Accepted Date: Apr. 10, 2026
  • Rev Recd Date: Apr. 08, 2026
  • Available Online: Apr. 15, 2026
    Abstract
  • Microneedles (MNs), as a transdermal drug delivery system, not only exhibit superior therapeutic efficacy but also ensure drug stability, holding remarkable advantages over conventional oral or intravenous administration routes. Recent advances in next-generation smart-responsive MN systems have focused on boosting real-time biomedical applicability through the integration of bioinspired, bio-derived, or biocompatible materials. These smart MNs possess unique characteristics, including skin adhesion, tunable dissolution kinetics, and environmental responsiveness, thereby enabling their deployment in wearable biosensors, rapid drug delivery systems, and responsive therapeutic platforms. This review specifically summarizes the progress of various stimulus-responsive MNs (e.g., pH-, temperature-, or electro-activated systems), which dynamically regulate drug release or modulate the therapeutic microenvironment in response to endogenous or exogenous signals such as pH variations, temperature fluctuations, and reactive oxygen species (ROS). Collectively, these smart MN systems open up new avenues for the clinical treatment and management of diabetes, cancer, and chronic cutaneous disorders.
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  • [1]
    J. Yang, H. Zhang, T. Hu, et al., Recent advances of microneedles used towards stimuli-responsive drug delivery, disease theranostics, and bioinspired applications, Chem. Eng. J. 426 (2021), 130561.
    [2]
    H. Kang, Z. Zuo, R. Lin, et al., The most promising microneedle device: Present and future of hyaluronic acid microneedle patch, Drug Deliv. 29 (2022) 3087-3110.
    [3]
    X. Li, X. Huang, J. Mo, et al., A fully integrated closed-loop system based on mesoporous microneedles-iontophoresis for diabetes treatment, Adv. Sci. 8 (2021), 2100827.
    [4]
    Y. Li, X. Ju, H. Fu, et al., Composite separable microneedles for transdermal delivery and controlled release of salmon calcitonin for osteoporosis therapy, ACS Appl. Mater. Interfaces 15 (2023) 638c650.
    [5]
    K. Kiryluk, D.B. Goldstein, J.W. Rowe, et al., Precision medicine in internal medicine, Ann. Intern. Med. 170 (2019) 635-642.
    [6]
    D. Kulkarni, F. Damiri, S. Rojekar, et al., Recent advancements in microneedle technology for multifaceted biomedical applications, Pharmaceutics 14 (2022), 1097.
    [7]
    K. Lee, M.J. Goudie, P. Tebon, et al., Non-transdermal microneedles for advanced drug delivery, Adv. Drug Deliv. Rev. 165-166 (2019) 41-59.
    [8]
    P. Makvandi, R. Jamaledin, G. Chen, et al., Stimuli-responsive transdermal microneedle patches, Mater. Today 47 (2021) 206-222.
    [9]
    Z. Tian, J. Cheng, J. Liu, et al., Dissolving graphene/poly(acrylic acid) microneedles for potential transdermal drug delivery and photothermal therapy, J. Nanosci. Nanotechnol. 19 (2019) 2453-2459.
    [10]
    M.C. Chen, Z. Lin, M.H. Ling, Near-infrared light-activatable microneedle system for treating superficial tumors by combination of chemotherapy and photothermal therapy, ACS Nano 10 (2016) 93-101.
    [11]
    Y.C. Kim, J.H. Park, M.R. Prausnitz, Microneedles for drug and vaccine delivery, Adv. Drug Deliv. Rev. 64 (2012) 1547-1568.
    [12]
    R. Donnelly, D. Douroumis, Microneedles for drug and vaccine delivery and patient monitoring, Drug Deliv. Transl. Res. 5 (2015) 311-312.
    [13]
    P. Serrano-Castaneda, J.J. Escobar-Chavez, I.M. Rodriguez-cruz, et al., Microneedles as enhancer of drug absorption through the skin and applications in medicine and cosmetology, J. Pharm. Pharm. Sci. 21 (2018) 73-93.
    [14]
    Z. Sartawi, C. Blackshields, W. Faisal, Dissolving microneedles: Applications and growing therapeutic potential, J. Control. Release 348 (2022) 186-205.
    [15]
    Y. Zhang, S. Wang, Y. Yang, et al., Scarless wound healing programmed by core-shell microneedles, Nat. Commun. 14 (2023), 3431.
    [16]
    A.V. Matadh, D. Jakka, S.G. Pragathi, et al., Polymer-coated polymeric (PCP) microneedles for controlled dermal delivery of 5-fluorouracil, AAPS PharmSciTech 24 (2022), 9.
    [17]
    V. Marturano, F. Abate, V. Ambrogi, et al., Smart coatings prepared via MAPLE deposition of polymer nanocapsules for light-induced release, Molecules 26 (2021), 2736.
    [18]
    C.L. Caudill, J.L. Perry, S. Tian, et al., Spatially controlled coating of continuous liquid interface production microneedles for transdermal protein delivery, J. Control. Release 284 (2018) 122-132.
    [19]
    Z. Lu, S. Du, J. Li, et al., Langmuir-blodgett-mediated formation of antibacterial microneedles for long-term transdermal drug delivery, Adv. Mater. 35 (2023), 2303388.
    [20]
    A. Ullah, H. Khan, H.J. Choi, et al., Smart microneedles with porous polymer coatings for pH-responsive drug delivery, Polymers 11 (2019), 1834.
    [21]
    A. Ullah, M. Jang, H. Khan, et al., Microneedle array with a pH-responsive polymer coating and its application in smart drug delivery for wound healing, Sens. Actuat. B Chem. 345 (2021), 130441.
    [22]
    H.S. Lee, H.R. Ryu, J.Y. Roh, et al., Bleomycin-coated microneedles for treatment of warts, Pharm. Res. 34 (2017) 101-112.
    [23]
    Y. Chen, B. Chen, Q. Wang, et al., Fabrication of coated polymer microneedles for transdermal drug delivery, J. Control. Release 265 (2017) 14-21.
    [24]
    I.J. Choi, H.R. Cha, S.J. Hwang, et al., Live vaccinia virus-coated microneedle array patches for smallpox vaccination and stockpiling, Pharmaceutics 13 (2021), 209.
    [25]
    D.H. Shim, T.T. Nguyen, P.G. Park, et al., Development of botulinum toxin a-coated microneedles for treating palmar hyperhidrosis, Mol. Pharmaceutics 16 (2019) 4913-4919.
    [26]
    H.T.T. Duong, Y. Yin, T. Thambi, et al., Smart vaccine delivery based on microneedle arrays decorated with ultra-pH-responsive copolymers for cancer immunotherapy, Biomaterials 185 (2018) 13-24.
    [27]
    L. Zhang, X. Xiu, Z. Li, et al., Coated porous microneedles for effective intradermal immunization with split influenza vaccine, ACS Biomater. Sci. Eng. 9 (2023) 6880-6890.
    [28]
    M.E. Mutlu, S. Ulag, M. Sengor, et al., Electrosprayed collagen/gentamicin nanoparticles coated microneedle patches for skin treatment, Mater. Lett. 305 (2021), 130844.
    [29]
    H.X. Nguyen, C.N. Nguyen, Microneedle-mediated transdermal delivery of biopharmaceuticals, Pharmaceutics 15 (2023), 277.
    [30]
    R. Zhang, Q. Miao, D. Deng, et al., Research progress of advanced microneedle drug delivery system and its application in biomedicine, Colloids Surf. B Biointerfaces 226 (2023), 113302.
    [31]
    Z. Wang, L. Xue, M. Li, et al., Au@SnO2-vertical graphene-based microneedle sensor for in-situ determination of abscisic acid in plants, Mater. Sci. Eng. C 127 (2021), 112237.
    [32]
    K. Yi, Y. Yu, Y. Wang, et al., Inverse opal microneedles arrays for fluorescence enhanced screening skin interstitial fluid biomarkers, Nano Today 47 (2022), 101655.
    [33]
    J. Cheng, J. Huang, Q. Xiang, et al., Hollow microneedle microfluidic paper-based chip for biomolecules rapid sampling and detection in interstitial fluid, Anal. Chim. Acta 1255 (2023), 341101.
    [34]
    Q. Zeng, M. Xu, W. Hu, et al., Porous colorimetric microneedles for minimally invasive rapid glucose sampling and sensing in skin interstitial fluid, Biosensors 13 (2023), 537.
    [35]
    X. Luo, Q. Yu, Y. Liu, et al., Closed-loop diabetes minipatch based on a biosensor and an electroosmotic pump on hollow biodegradable microneedles, ACS Sens. 7 (2022) 1347-1360.
    [36]
    X. Luo, Q. Yu, L. Yang, et al., Wearable, sensing-controlled, ultrasound-based microneedle smart system for diabetes management, ACS Sens. 8 (2023) 1710-1722.
    [37]
    S.S. Gade, S. Pentlavalli, D. Mishra, et al., Injectable depot forming thermoresponsive hydrogel for sustained intrascleral delivery of sunitinib using hollow microneedles, J. Ocul. Pharmacol. Ther. 38 (2022) 433-448.
    [38]
    A. Younas, Z. Dong, Z. Hou, et al., A chitosan/fucoidan nanoparticle-loaded pullulan microneedle patch for differential drug release to promote wound healing, Carbohydr. Polym. 306 (2023), 120593.
    [39]
    L.K. Vora, A.H. Sabri, Y. Naser, et al., Long-acting microneedle formulations, Adv. Drug Deliv. Rev. 201 (2023), 115055.
    [40]
    X. Huang, L. Chen, T. Sha, et al., In situ tyrosinase monitoring by wearable microneedle patch toward clinical melanoma screening, ACS Nano 17 (2023) 20073-20086.
    [41]
    F. Hu, Q. Gao, J. Liu, et al., Smart microneedle patches for wound healing and management, J. Mater. Chem. B 11 (2023) 2830-2851.
    [42]
    B.H.J. Gowda, M.G. Ahmed, A. Sahebkar, et al., Stimuli-responsive microneedles as a transdermal drug delivery system: A demand-supply strategy, Biomacromolecules 23 (2022) 1519-1544.
    [43]
    J. Shan, X. Zhang, B. Kong, et al., Coordination polymer nanozymes-integrated colorimetric microneedle patches for intelligent wound infection management, Chem. Eng. J. 444 (2022), 136640.
    [44]
    A. Zhang, Y. Zeng, B. Xiong, et al., A pH-responsive core-shell microneedle patch with self-monitoring capability for local long-lasting analgesia, Adv. Funct. Mater. 34 (2024), 2314048.
    [45]
    S. Wei, G. Quan, C. Lu, et al., Dissolving microneedles integrated with pH-responsive micelles containing AIEgen with ultra-photostability for enhancing melanoma photothermal therapy, Biomater. Sci. 8 (2020) 5739-5750.
    [46]
    Y. Huang, H. Lai, J. Jiang, et al., pH-activatable oxidative stress amplifying dissolving microneedles for combined chemo-photodynamic therapy of melanoma, Asian J. Pharm. Sci. 17 (2022) 679-696.
    [47]
    J. Xie, X. Zhu, M. Wang, et al., Dissolving microneedle-mediated transdermal delivery of flurbiprofen axetil-loaded pH-responsive liposomes for arthritis treatment, Chem. Eng. J. 482 (2024), 148840.
    [48]
    F. Luo, G. Chen, W. Xu, et al., Microneedle-array patch with pH-sensitive formulation for glucose-responsive insulin delivery, Nano Res. 14 (2021) 2689-2696.
    [49]
    S. Jung, S. Chang, N.E. Kim, et al., Curcumin/zeolitic imidazolate framework-8 nanoparticle-integrated microneedles for pH-responsive treatment of skin disorders, ACS Appl. Nano Mater. 5 (2022) 13671-13679.
    [50]
    B. Zhao, W. Guo, X. Zhou, et al., Ferroptosis-mediated synergistic therapy of hypertrophic scarring based on metal-organic framework microneedle patch, Adv. Funct. Mater. 33 (2023), 2300575.
    [51]
    T. Wen, Z. Lin, Y. Zhao, et al., Bioresponsive nanoarchitectonics-integrated microneedles for amplified chemo-photodynamic therapy against acne vulgaris, ACS Appl. Mater. Interfaces 13 (2021) 48433-48448.
    [52]
    X. Cheng, S. Hu, K. Cheng, Microneedle patch delivery of PROTACs for anti-cancer therapy, ACS Nano 17 (2023) 11855-11868.
    [53]
    X. Li, Q. Xu, P. Zhang, et al., Cutaneous microenvironment responsive microneedle patch for rapid gene release to treat subdermal tumor, J. Control. Release 314 (2019) 72-80.
    [54]
    Z. Qi, Z. Yan, G. Tan, et al., Smart responsive microneedles for controlled drug delivery, Molecules 28 (2023), 7411.
    [55]
    S. Roussel, J. Udabe, A. Bin Sabri, et al., Leveraging novel innovative thermoresponsive polymers in microneedles for targeted intradermal deposition, Int. J. Pharm. 652 (2024), 123847.
    [56]
    H. Lee, T.K. Choi, Y.B. Lee, et al., A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy, Nat. Nanotechnol. 11 (2016) 566-572.
    [57]
    H. Lee, C. Song, Y.S. Hong, et al., Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module, Sci. Adv. 3 (2017), e1601314.
    [58]
    Y. Liao, C. Liu, L. Guo, et al., Temperature-responsive detachable microneedles integrated with minoxidil nanoparticle for effectively promoting hair regrowth, Chem. Eng. J. 495 (2024), 153666.
    [59]
    R. Xu, H. Guo, X. Chen, et al., Smart hydrothermally responsive microneedle for topical tumor treatment, J. Control. Release 358 (2023) 566-578.
    [60]
    H. Chang, S.W.T. Chew, M. Zheng, et al., Cryomicroneedles for transdermal cell delivery, Nat. Biomed. Eng. 5 (2021) 1008-1018.
    [61]
    B. Kong, R. Liu, J. Shan, et al., Frozen reinforced microneedles loaded with NIR-photothermal nanozyme for keratitis treatment, Nano Today 52 (2023), 102000.
    [62]
    N. El-Sayed, K. Elbadri, A. Correia, et al., Polyethylene glycol-stabilized gold nanostars-loaded microneedles for photothermal therapy of melanoma, Adv. Mater. Technol. 8 (2023), 2301159.
    [63]
    G.A.R.R. Naik, A. Gupta, D. Datta, et al., Synergistic combinational photothermal therapy-based approaches for cancer treatment, FlatChem 50 (2025), 100834.
    [64]
    T. Peng, Y. Huang, X. Feng, et al., TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor, Acta Pharm. Sin. B 11 (2021) 3297-3309.
    [65]
    Q. Lei, D. He, L. Ding, et al., Microneedle patches integrated with biomineralized melanin nanoparticles for simultaneous skin tumor photothermal therapy and wound healing, Adv. Funct. Mater. 32 (2022), 2113269.
    [66]
    P. Pei, F. Yang, J. Liu, et al., Composite-dissolving microneedle patches for chemotherapy and photothermal therapy in superficial tumor treatment, Biomater. Sci. 6 (2018) 1414-1423.
    [67]
    H. Wang, W. Wang, C. Li, et al., Flav7 + DOX co-loaded separable microneedle for light-triggered chemo-thermal therapy of superficial tumors, Chem. Eng. J. 428 (2022), 131913.
    [68]
    X. Pu, X. Ju, W. Liu, et al., Stimulus-responsive nanoparticle-integrated dissolving microneedles for synergetic chemo-photothermal therapy of superficial skin tumors, Ind. Eng. Chem. Res. 61 (2022) 7982-7995.
    [69]
    X. Yu, J. Zhao, D. Fan, A dissolving microneedle patch for atibiotic/enzymolysis/photothermal triple therapy against bacteria and their biofilms, Chem. Eng. J. 437 (2022), 135475.
    [70]
    F. Liu, Z. Cheng, H. Yi, NIR light-activatable dissolving microneedle system for melanoma ablation enabled by a combination of ROS-responsive chemotherapy and phototherapy, J. Nanobiotechnol. 21 (2023), 61.
    [71]
    Y. Zhao, Y. Zhou, D. Yang, et al., Intelligent and spatiotemporal drug release based on multifunctional nanoparticle-integrated dissolving microneedle system for synergetic chemo-photothermal therapy to eradicate melanoma, Acta Biomater. 135 (2021) 164-178.
    [72]
    J. Tao, B. Wang, Y. Dong, et al., Photothermal and acid-responsive fucoidan-CuS bubble pump microneedles for combined CDT/PTT/CT treatment of melanoma, ACS Appl. Mater. Interfaces 15 (2023) 40267-40279.
    [73]
    S. Yu, H. Ni, X. Xu, et al., Subcutaneous rapid dissolution microneedle patch integrated with CuO2 and disulfiram for augmented antimelanoma efficacy through multimodal synergy of photothermal therapy, chemodynamic therapy, and chemotherapy, ACS Biomater. Sci. Eng. 9 (2023) 6425-6437.
    [74]
    G. Song, Y. Sun, T. Liu, et al., Transdermal delivery of Cu-doped polydopamine using microneedles for photothermal and chemodynamic synergistic therapy against skin melanoma, Chem. Eng. J. 426 (2021), 130790.
    [75]
    Y. Sun, M. Chen, D. Yang, et al., Self-assembly nanomicelle-microneedle patches with enhanced tumor penetration for superior chemo-photothermal therapy, Nano Res. 15 (2022) 2335-2346.
    [76]
    T. Wang, G. Chen, S. Zhang, et al., Steerable microneedles enabling deep delivery of photosensitizers and CRISPR/Cas9 systems for effective combination cancer therapy, Nano Lett. 23 (2023) 7990-7999.
    [77]
    A.F. Moreira, C.F. Rodrigues, T.A. Jacinto, et al., Poly (vinyl alcohol)/chitosan layer-by-layer microneedles for cancer chemo-photothermal therapy, Int. J. Pharm. 576 (2020), 118907.
    [78]
    L. Dong, Y. Li, Z. Li, et al., Au nanocage-strengthened dissolving microneedles for chemo-photothermal combined therapy of superficial skin tumors, ACS Appl. Mater. Interfaces 10 (2018) 9247-9256.
    [79]
    Y. Fang, L. Zhuo, Hang Yuan, et al., Construction of graphene quantum dot-based dissolving microneedle patches for the treatment of bacterial keratitis, Int. J. Pharm. 639 (2023), 122945.
    [80]
    T.R. Everett, I.B. Wilkinson, C.C. Lees, Pre-eclampsia: the Potential of GSNO Reductase Inhibitors, Curr. Hypertens. Rep. 19 (2017), 20.
    [81]
    J. Cui, J. Huang, Y. Yan, et al., Ferroferric oxide loaded near-infrared triggered photothermal microneedle patch for controlled drug release, J. Colloid Interface Sci. 617 (2022) 718-729.
    [82]
    D. He, X. Liu, J. Jia, et al., Magnetic field-directed deep thermal therapy via double-layered microneedle patch for promoting tissue regeneration in infected diabetic skin wounds, Adv. Funct. Mater. 34 (2024), 2306357.
    [83]
    P. Li, C. Liu, Y. Zhao, et al., Multifunctional covalent organic framework-based microneedle patch for melanoma treatment, Biomacromolecules 24 (2023) 3846-3857.
    [84]
    W. Zhu, J. Mei, X. Zhang, et al., Photothermal nanozyme-based microneedle patch against refractory bacterial biofilm infection via iron-actuated janus ion therapy, Adv. Mater. 34 (2022), 2207961.
    [85]
    K. Liao, B. Niu, H. Dong, et al., A spark to the powder keg: Microneedle-based antitumor nanomedicine targeting reactive oxygen species accumulation for chemodynamic/photothermal/chemotherapy, J. Colloid Interface Sci. 628 (2022) 189-203.
    [86]
    W. Qin, G. Quan, Y. Sun, et al., Dissolving microneedles with spatiotemporally controlled pulsatile release nanosystem for synergistic chemo-photothermal therapy of melanoma, Theranostics 10 (2020) 8179-8196.
    [87]
    D. Liu, Y. Zhang, G. Jiang, et al., Fabrication of dissolving microneedles with thermal-responsive coating for NIR-triggered transdermal delivery of metformin on diabetic rats, ACS Biomater. Sci. Eng. (2018), acsbiomaterials.8b00159.
    [88]
    X. Lei, M. Li, C. Wang, et al., Degradable microneedle patches loaded with antibacterial gelatin nanoparticles to treat staphylococcal infection-induced chronic wounds, Int. J. Biol. Macromol. 217 (2022) 55-65.
    [89]
    A. Zhang, X. Jiang, B. Xiong, et al., Sustained-release photothermal microneedles for postoperative incisional analgesia and wound healing via hydrogen therapy, Adv. Sci. 12 (2025), e03698.
    [90]
    B. Wu, J. Fu, Y. Zhou, et al., Tailored core-shell dual metal-organic frameworks as a versatile nanomotor for effective synergistic antitumor therapy, Acta Pharm. Sin. B 10 (2020) 2198-2211.
    [91]
    Y. Li, L. Zheng, W. Cao, et al., 5-aminolevulinic acid-loaded dissolving microneedle array for photodynamic therapy of rheumatoid arthritis on rats, Biomed. Pharmacother. 162 (2023), 114684.
    [92]
    Y. Shao, K. Dong, X. Lu, et al., Bioinspired 3D-printed MXene and spidroin-based near-infrared light-responsive microneedle scaffolds for efficient wound management, ACS Appl. Mater. Interfaces 14 (2022) 56525-56534.
    [93]
    X. Lei, K. Cheng, Y. Hu, et al., Gelatinase-responsive biodegradable targeted microneedle patch for abscess wound treatment of S. aureus infection, Int. J. Biol. Macromol. 253 (2023), 127548.
    [94]
    Y. Zhang, J. Wang, J. Yu, et al., Bioresponsive microneedles with a sheath structure for H2O2 and pH cascade-triggered insulin delivery, Small 14 (2018), 1704181.
    [95]
    J. Yu, C. Qian, Y. Zhang, et al., Hypoxia and H2O2 dual-sensitive vesicles for enhanced glucose-responsive insulin delivery, Nano Lett. 17 (2017) 733-739.
    [96]
    Q. Chen, Z. Xiao, C. Wang, et al., Microneedle patches loaded with nanovesicles for glucose transporter-mediated insulin delivery, ACS Nano 16 (2022) 18223-18231.
    [97]
    M. Sang, M. Cho, S. Lim, et al., Fluorescent-based biodegradable microneedle sensor array for tether-free continuous glucose monitoring with smartphone application, Sci. Adv. 9 (2023), eadh1765.
    [98]
    Z. Qi, X. Tao, G. Tan, et al., Electro-responsive silk fibroin microneedles for controlled release of insulin, Int. J. Biol. Macromol. 242 (2023), 124684.
    [99]
    J.O. Jeong, Y.M. Lim, J.Y. Lee, et al., Polyvinylpyrrolidone based graphene oxide hydrogels by radiation crosslinking for conductive microneedle patches, Eur. Polym. J. 184 (2023), 111726.
    [100]
    A. Anderson, C. Hegarty, C. Casimero, et al., Electrochemically controlled dissolution of nanocarbon-cellulose acetate phthalate microneedle arrays, ACS Appl. Mater. Interfaces 11 (2019) 35540-35547.
    [101]
    Y. Yang, L. Xu, D. Jiang, et al., Self-powered controllable transdermal drug delivery system, Adv. Funct. Mater. 31 (2021), 2104092.
    [102]
    Y. Yang, R. Luo, S. Chao, et al., Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation, Nat. Commun. 13 (2022), 6908.
    [103]
    L. Kong, H. Wen, Y. Luo, et al., Dual-conductive and stiffness-morphing microneedle patch enables continuous in planta monitoring of electrophysiological signal and ion fluctuation, ACS Appl. Mater. Interfaces 15 (2023) 43515-43523.
    [104]
    H. Liu, W. Qin, X. Li, et al., Molecularly imprinted electrochemical sensors based on Ti3C2Tx-MXene and graphene composite modifications for ultrasensitive crtisol detection, Anal. Chem. 95 (2023) 16079-16088.
    [105]
    D. Zhu, Y. Tan, L. Zheng, et al., Microneedle-coupled epidermal sensors for in-situ-multiplexed ion detection in interstitial fluids, ACS Appl. Mater. Interfaces (2023), acsami.3c00573.
    [106]
    L.R. Panicker, F. Shamsheera, R. Narayan, et al., Wearable electrochemical microneedle sensors based on the graphene-silver-chitosan nanocomposite for real-time continuous monitoring of the depression biomarker serotonin, ACS Appl. Nano Mater. 6 (2023) 20601-20611.
    [107]
    C. Wang, L. Zhou, Z. Han, et al., Microneedle system carrying momordin ic-loaded ROS-responsive hydrogel ameliorates psoriasis via targeted anti-inflammatory and reactive oxygen species (ROS)-scavenging mechanisms, Int. J. Pharm. 676 (2025), 125530.
    [108]
    J. Shan, X. Zhang, L. Wang, et al., Spatiotemporal catalytic nanozymes microneedle patches with opposite properties for wound management, Small 19 (2023), 2302347.
    [109]
    W. Ma, X. Zhang, Y. Liu, et al., Polydopamine decorated microneedles with Fe-MSC-derived nanovesicles encapsulation for wound healing, Adv. Sci. 9 (2022), 2103317.
    [110]
    Y. Zhou, L. Yang, Y. Lyu, et al., Topical delivery of ROS-responsive methotrexate prodrug nanoassemblies by a dissolvable microneedle patch for psoriasis therapy, Int. J. Nanomed. 18 (2023) 899-915.
    [111]
    Z. Wang, C.H.T. Kwong, H. Zhao, et al., Microalgae microneedle supplies oxygen for antiphotoaging treatment, ACS Appl. Bio Mater. 6 (2023) 3463-3471.
    [112]
    X. Yang, M. Jia, Z. Li, et al., In-situ synthesis silver nanoparticles in chitosan/betilla striata polysaccharide composited microneedles for infected and susceptible wound healing, Int. J. Biol. Macromol. 215 (2022) 550-559.
    [113]
    X. Zhang, J. Gan, L. Fan, et al., Bioinspired adaptable indwelling microneedles for treatment of diabetic ulcers, Adv. Mater. 35 (2023), 2210903.
    [114]
    J. Yang, S. Zheng, D. Ma, et al., Masticatory system-inspired microneedle theranostic platform for intelligent and precise diabetic management, Sci. Adv. 8 (2022), eabo6900.
    [115]
    X. Zhang, Y. Cheng, R. Liu, et al., Globefish-inspired balloon catheter with intelligent microneedle coating for endovascular drug delivery, Adv. Sci. 9 (2022), 2204497.
    [116]
    H. Lu, W. Shao, B. Gao, et al., Intestine-inspired wrinkled MXene microneedle dressings for smart wound management, Acta Biomater. 159 (2023) 201-210.
    [117]
    Y. Wang, B. Gao, B. He, Toward efficient wound management: Bioinspired microfluidic and microneedle patch, Small 19 (2023), 2206270.
    [118]
    M. Guo, Y. Wang, B. Gao, et al., Shark tooth-inspired microneedle dressing for intelligent wound management, ACS Nano 15 (2021) 15316-15327.
    [119]
    D. Huang, X. Fu, X. Zhang, et al., Christmas tree-shaped microneedles as FOLFIRINOX spatiotemporal delivery system for pancreatic cancer treatment, Research 2022 (2022), 2022/9809417.
    [120]
    L. Zhang, L. Zhang, X. Zhang, et al., Responsive fluorescent probes for cellular microenvironment and redox small biomolecules, Trac Trends Anal. Chem. 169 (2023), 117377.
    [121]
    J.B. Lugagne, G. Brackx, E. Seyrek, et al., Assembly and characterizations of bifunctional fluorescent and magnetic microneedles with one decade length tunability, Adv. Funct. Mater. 27 (2017), 1700362.
    [122]
    S. Babity, A.K. Polomska, F. Couture, et al., Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function, J. Control. Release 327 (2020) 350-359.
    [123]
    Q. Wu, C. Pan, P. Shi, et al., On-demand transdermal drug delivery platform based on wearable acoustic microneedle array, Chem. Eng. J. 477 (2023), 147124.
    [124]
    X. Wu, D. Huang, Y. Xu, et al., Microfluidic templated stem cell spheroid microneedles for diabetic wound treatment, Adv. Mater. 35 (2023), 2301064.
    [125]
    Y. Liu, Z. Zhang, C. Wang, et al., Biodegradable and dissolvable resveratrol nanocrystals non-silicon microneedles for transdermal drug delivery, J. Drug Deliv. Sci. Technol. 86 (2023), 104653.
    [126]
    J. Chen, H. Niu, L. Guan, et al., Microneedle-assisted transdermal delivery of 2D bimetallic metal-organic framework nanosheet-based cascade biocatalysts for enhanced catalytic therapy of melanoma, Adv. Healthc. Mater. 12 (2023), 2202474.
    [127]
    Q. Wang, X. Yang, X. Gu, et al., Celecoxib nanocrystal-loaded dissolving microneedles with highly efficient for osteoarthritis treatment, Int. J. Pharm. 625 (2022), 122108.
    [128]
    S.H. Joo, J. Kim, J. Hong, et al., Dissolvable self-locking microneedle patches integrated with immunomodulators for cancer immunotherapy, Adv. Mater. 35 (2023), 2209966.
    [129]
    C. Kuwentrai, J. Yu, L. Rong, et al., Intradermal delivery of receptor-binding domain of SARS-CoV-2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice, Bioeng. Transl. Med. 6 (2021), e10202.
    [130]
    Q. Li, R. Xu, H. Fan, et al., Smart mushroom-inspired imprintable and lightly detachable (MILD) microneedle patterns for effective COVID-19 vaccination and decentralized information storage, ACS Nano 16 (2022) 7512-7524.
    [131]
    I.J. Choi, A. Kang, M.H. Ahn, et al., Insertion-responsive microneedles for rapid intradermal delivery of canine influenza vaccine, J. Control. Release 286 (2018) 460-466.
    [132]
    T. Zhang, B. Sun, W. Ding, et al., Combining rapid degrading microneedles with slow-released drug delivery system for the treatment of alopecia areata, Chem. Eng. J. 471 (2023), 144351.
    [133]
    Z. Zhang, W. Li, D. Chang, et al., A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch, Bioact. Mater. 24 (2023) 81-95.
    [134]
    S. Rojekar, L.K. Vora, I.A. Tekko, et al., Etravirine-loaded dissolving microneedle arrays for long-acting delivery, Eur. J. Pharm. Biopharm. 165 (2021) 41-51.
    [135]
    Q. Chen, Y. Cheng, Z. Huang, et al., All drug glassy microneedle patches for instantaneous transdermal delivery, Adv. Mater. 38 (2026), e12849.
    [136]
    M. Wu, H. Liu, D. Li, et al., Smart-responsive multifunctional therapeutic system for improved regenerative microenvironment and accelerated bone regeneration via mild photothermal therapy, Adv. Sci. 11 (2024), 2304641.
    [137]
    A. Carcamo-Martinez, B. Mallon, J. Dominguez-Robles, et al., Plasmonic photothermal microneedle arrays and single needles for minimally-invasive deep in-skin hyperthermia, J. Mater. Chem. B 8 (2020) 5425-5433.
    [138]
    S. Yao, J. Chi, Y. Wang, et al., Zn-MOF encapsulated antibacterial and degradable microneedles array for promoting wound healing, Adv. Healthc. Mater. 10 (2021), 2100056.
    [139]
    L. Fan, X. Zhang, X. Liu, et al., Responsive hydrogel microcarrier-integrated microneedles for versatile and controllable drug delivery, Adv. Healthc. Mater. 10 (2021), 2002249.
    [140]
    L. Fan, X. Zhang, M. Nie, et al., Photothermal responsive microspheres-triggered separable microneedles for versatile drug delivery, Adv. Funct. Mater. 32 (2022), 2110746.
    [141]
    Z. Chen, T. Hu, R. Wang, et al., Local delivery of glabridin by biomolecular microneedle to accelerate infected wound healing, Adv. Healthc. Mater. 13 (2024), 2302470.
    [142]
    P. Wang, Y. Pu, Y. Ren, et al., Enzyme-regulated NO programmed to release from hydrogel-forming microneedles with endogenous/photodynamic synergistic antibacterial for diabetic wound healing, Int. J. Biol. Macromol. 226 (2023) 813-822.
    [143]
    J. Yang, G. Li, J. Yuan, et al., A smart silk-based microneedle for cancer stem cell synergistic immunity/hydrogen therapy, Adv. Funct. Mater. 32 (2022), 2206406.
    [144]
    J. Li, Y. Feng, Y. He, et al., Thermosensitive hydrogel microneedles for controlled transdermal drug delivery, Acta Biomater. 153 (2022) 308-319.
    [145]
    J. Chi, X. Zhang, C. Chen, et al., Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing, Bioact. Mater. 5 (2020) 253-259.
    [146]
    B. Hou, A. Xu, S. Zhang, et al., Application of sodium alginate and polyethylene glycol bilayer multifunctional hydrogel microneedles in infectious and diabetic wounds, Int. J. Biol. Macromol. 310 (2025), 143471.
    [147]
    B. Lu, A. GhavamiNejad, J.F. Liu, et al., “Smart” composite microneedle patch stabilizes glucagon and prevents nocturnal hypoglycemia: Experimental studies and molecular dynamics simulation, ACS Appl. Mater. Interfaces 14 (2022) 20576-20590.
    [148]
    J.F. Liu, A. GhavamiNejad, B. Lu, et al., “Smart” matrix microneedle patch made of self-crosslinkable and multifunctional polymers for delivering insulin on-demand, Adv. Sci. 10 (2023), 2303665.
    [149]
    S. Gholami, I. Zarkesh, M.H. Ghanian, et al., Dynamically capped hierarchically porous microneedles enable post-fabrication loading and self-regulated transdermal delivery of insulin, Chem. Eng. J. 421 (2021), 127823.
    [150]
    Y. Wang, S. Cheng, W. Hu, et al., Polymer-grafted hollow mesoporous silica nanoparticles integrated with microneedle patches for glucose-responsive drug delivery, Front. Mater. Sci. 15 (2021) 98-112.
    [151]
    Y. Fu, P. Liu, M. Chen, et al., On-demand transdermal insulin delivery system for type 1 diabetes therapy with no hypoglycemia risks, J. Colloid Interface Sci. 605 (2022) 582-591.
    [152]
    Y. Lu, H. Yu, L. Wang, et al., Preparation of phenylboronic acid-based glucose-responsive hydrogels and microneedles for regulated delivery of insulin, Eur. Polym. J. 192 (2023), 112061.
    [153]
    S. Chen, T. Miyazaki, M. Itoh, et al., Temperature-stable boronate gel-based microneedle technology for self-regulated insulin delivery, ACS Appl. Polym. Mater. 2 (2020) 2781-2790.
    [154]
    Z. Lin, Y.L. Chen, W. Lei, et al., Hierarchically structured conductive hydrogels for electrically programmable drug delivery in a diabetic wound healing electronic patch, J. Control. Release 383 (2025), 113760.
    [155]
    S. Murdan, Electro-responsive drug delivery from hydrogels, J. Control. Release 92 (2003) 1-17.
    [156]
    Q. Yang, Y. Wang, T. Liu, et al., Microneedle array encapsulated with programmed DNA hydrogels for rapidly sampling and sensitively sensing of specific microRNA in dermal interstitial fluid, ACS Nano 16 (2022) 18366-18375.
    [157]
    S. Indermun, Y.E. Choonara, P. Kumar, et al., Ex vivo evaluation of a microneedle array device for transdermal application, Int. J. Pharm. 496 (2015) 351-359.
    [158]
    L. Zheng, D. Zhu, W. Wang, et al., A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue, Sens. Actuat. B Chem. 372 (2022), 132626.
    [159]
    H. Li, X. Zheng, Z. Gao, et al., ROS-responsive core-shell microneedles based on simultaneous efficient type I/II photosensitizers for photodynamic against bacterial biofilm infections, Adv. Funct. Mater. 35 (2025), 2401477.
    [160]
    H. Ding, Y. Cui, J. Yang, et al., ROS-responsive microneedles loaded with integrin avβ6-blocking antibodies for the treatment of pulmonary fibrosis, J. Control. Release 360 (2023) 365-375.
    [161]
    Y. Yang, P. Wang, Y. Gong, et al., Curcumin-zinc framework encapsulated microneedle patch for promoting hair growth, Theranostics 13 (2023) 3675-3688.
    [162]
    D. Bi, F. Qu, W. Xiao, et al., Reactive oxygen species-responsive gel-based microneedle patches for prolonged and intelligent psoriasis management, ACS Nano 17 (2023) 4346-4357.
    [163]
    X. Cheng, R.J. Lee, The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery, Adv. Drug Deliv. Rev. 99 (2016) 129-137.
    [164]
    Z. Le, J. Yu, Y.J. Quek, et al., Design principles of microneedles for drug delivery and sampling applications, Mater. Today 63 (2023) 137-169.
    [165]
    Z. Luo, Y. Wang, J. Li, et al., Tailoring hyaluronic acid hydrogels for biomedical applications, Adv. Funct. Mater. 33 (2023), 2306554.
    [166]
    J.G. Turner, L.R. White, P. Estrela, et al., Hydrogel-forming microneedles: Current advancements and future trends, Macromol. Biosci. 21 (2021), 2000307.
    [167]
    A.H. Bin Sabri, Q.K. Anjani, R.F. Donnelly, Synthesis and characterization of sorbitol laced hydrogel-forming microneedles for therapeutic drug monitoring, Int. J. Pharm. 607 (2021), 121049.
    [168]
    J. Liang, Y. Yu, C. Li, et al., Tofacitinib combined with melanocyte protector α-MSH to treat vitiligo through dextran based hydrogel microneedles, Carbohydr. Polym. 305 (2023), 120549.
    [169]
    Y. Xue, C. Chen, R. Tan, et al., Artificial intelligence-assisted bioinformatics, microneedle, and diabetic wound healing: A “new deal” of an old drug, ACS Appl. Mater. Interfaces 14 (2022) 37396-37409.
    [170]
    X. Gu, Z. Wu, D. Wu, et al., Hydrogel microneedle patch for treatment of liver fibrosis, Mater. Today Adv. 20 (2023), 100417.
    [171]
    Z. Qi, J. Cao, X. Tao, et al., Silk fibroin microneedle patches for the treatment of insomnia, Pharmaceutics 13 (2021), 2198.
    [172]
    J. Chi, L. Sun, L. Cai, et al., Chinese herb microneedle patch for wound healing, Bioact. Mater. 6 (2021) 3507-3514.
    [173]
    X. Zhang, G. Chen, X. Fu, et al., Magneto-responsive microneedle robots for intestinal macromolecule delivery, Adv. Mater. 33 (2021), 2104932.
    [174]
    M. Lu, L. Fan, H. Chen, et al., Multifunctional inverse opal microneedle arrays for drug delivery and monitoring, Small 18 (2022), 2201889.
    [175]
    X. Zhou, S. Huang, D. Zhang, et al., Gold nanocluster-based fluorescent microneedle platform toward visual detection of ATP, Anal. Chem. 95 (2023) 12104-12112.
    [176]
    Y. Pei, Z. Chen, X. Wang, et al., Dendritic cells-targeted delivery of mRNA vaccines and dual siRNAs via microneedles effectively inhibits tumor growth, J. Drug Deliv. Sci. Technol. 107 (2025), 106768.
    [177]
    M.M. Driskill, I.A. Coates, P.J. Hurst, et al., Lyophilized SARS-CoV-2 self-amplifying RNA vaccines for microneedle array patch delivery, J. Control. Release 384 (2025), 113944.
    [178]
    C. He, P. He, L. Ye, et al., Buccal microneedle-delivered ferritin nanovaccines induce strong respiratory immunity against pseudomonas aeruginosa, J. Control. Release 388 (2025), 114280.
    [179]
    P. Van Damme, F. Oosterhuis-Kafeja, M. Van der Wielen, et al., Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults, Vaccine 27 (2009) 454-459.
    [180]
    H. Xue, C. Zhang, D. Lin, et al., Isoliquiritigenin micellar microneedle for pH monitoring and diabetic wound healing, Mater. Today Bio 35 (2025), 102356.
    [181]
    Q. Xuan, J. Cai, Y. Gao, et al., Amyloid-templated ceria nanozyme reinforced microneedle for diabetic wound treatments, Adv. Mater. 37 (2025), 2417774.
    [182]
    H. Li, F. Meng, C. Hu, et al., Gradient solvent replacement-mediated formation of high-strength hydrogel-forming microneedle for long-term drug delivery, Adv. Sci. 12 (2025), 2500833.
    [183]
    O.C. Steinbach, Industry update: The latest developments in therapeutic delivery, Ther. Deliv. 5 (2014) 505-509.
    [184]
    Z. Xing, X. Zhang, C. Zhao, et al., Microenvironment-responsive recombinant collagen XVII-based composite microneedles for the treatment of androgenetic alopecia, Acta Biomater. 200 (2025) 400-415.
    [185]
    X. Lin, Q. Jia, X. Lin, et al., Galvanic cell bipolar microneedle patches for reversing photoaging wrinkles, Adv. Mater. 37 (2025), 2500552.
    [186]
    A.A. Anis Basily, A.A. Halim Imam, H.M. Ahmed Saleh, Comparative clinical trial of dermapen microneedling and platelet-rich plasma versus dermapen microneedling alone in the treatment of stretch marks in egyptian adults, QJM 117 (2024), hcae070.178.
    [187]
    F. Moawad, Y. Ruel, R. Pouliot, et al., Microneedle technology in psoriasis management: Mechanistic insights, technological innovation, clinical progress, and challenges, Adv. Healthc. Mater. 15 (2026), e04294.
    [188]
    X. Quan, J. Lu, Y. Liu, et al., Microneedle technologies for cancer diagnostics: From fabrication to biosensing, Adv. Healthc. Mater. 15 (2026), e03698.
    [189]
    L.K. Vora, A.J. Courtenay, I.A. Tekko, et al., Pullulan-based dissolving microneedle arrays for enhanced transdermal delivery of small and large biomolecules, Int. J. Biol. Macromol. 146 (2020) 290-298.
    [190]
    Q. Yan, J. Weng, S. Shen, et al., Finite element analysis for biodegradable dissolving microneedle materials on skin puncture and mechanical performance evaluation, Polymers 13 (2021), 3043.
    [191]
    X. Luo, L. Yang, Y. Cui, Microneedles: Materials, fabrication, and biomedical applications, Biomed. Microdevices 25 (2023), 20.
    [192]
    L. Pan, X. Li, H. Li, et al., Biological application of polypropylene microneedles prepared by ultrasonic plasticization microinjection molding technology, ACS Appl. Polym. Mater. 7 (2025) 11334-11342.
    [193]
    J.M. Kronenfeld, L. Rother, M.A. Saccone, et al., Roll-to-roll, high-resolution 3D printing of shape-specific particles, Nature 627 (2024) 306-312.
    [194]
    I. Menon, P. Bagwe, K.B. Gomes, et al., Microneedles: a new generation vaccine delivery system, Micromachines 12 (2021), 435.
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