Multiple gastric cancer tissue proteomic identification predicts CLU as a biomarker for anti-PD-1 immunotherapy

doi: 10.1016/j.jpha.2026.101615

• Yu Zhang^a,b,j , 
• Hao-Yi Zhu^a,j , 
• Cong-Cong Ma^a,j , 
• Ning Wang^c , 
• Yan Li^d,e , 
• Guo-Liang Lu^e,f , 
• Xing-Jie Dai^a,j , 
• Bo Wang^a,j , 
• MAA Mamun^a,j , 
• Ying Li^a,j , 
• Xiao-Ying Zhao^a,j , 
• Jing-Ru Pang^a,j , 
• Ning-Jie Guo^a,j , 
• Feng-Yu Qi^a,j , 
• Jian-Gang Sun^g , 
• Hong-Min Liu^a,j , 
• Feng-Wu Liu^b , 
• Piet Herdewijn^{b,h ,  ,}  , 
• Long-Fei Zhao^{i ,  ,}  , 
• Yi-Chao Zheng^{a,b,j ,  ,} 

• a. State Key Laboratory of Metabolic Dysregulation&Prevention and Treatment of Esophageal Cancer, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, China;

• b. XNA platform, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China;

• c. School of Chinese Medicine, The University of Hong Kong, Hong Kong, China;

• d. Department of Biomedicine and Medical Diagnostics, School of Science, Auckland University of Technology, Auckland 1010, New Zealand;

• e. Maurice Wilkins Centre, The University of Auckland, Auckland 1142, New Zealand;

• f. Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1142, New Zealand;

• g. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China;

• h. Rega Institute for Medical Research, Medicinal Chemistry, 3000 Leuven, Belgium;

• i. School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China;

• j. Key Laboratory of Henan Province for Small Molecule Drug Discovery and Application, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China