GSH-triggered release of anabasine in mitochondria for synergistic chemotherapy assisted by OATP transportation

Miao Zhang; Ling-Li Wang; Si-Ling Chen; Yan-Ping Liu; Ming-Hua Zheng; Jing-Yi Jin

doi:10.1016/j.jpha.2026.101565

Article Contents

Article Navigation > Journal of Pharmaceutical Analysis > 2026 > Accepted Manu

Miao Zhang, Ling-Li Wang, Si-Ling Chen, Yan-Ping Liu, Ming-Hua Zheng, Jing-Yi Jin. GSH-triggered release of anabasine in mitochondria for synergistic chemotherapy assisted by OATP transportation[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101565

Citation:

Miao Zhang, Ling-Li Wang, Si-Ling Chen, Yan-Ping Liu, Ming-Hua Zheng, Jing-Yi Jin. GSH-triggered release of anabasine in mitochondria for synergistic chemotherapy assisted by OATP transportation[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101565

Citation:

Miao Zhang, Ling-Li Wang, Si-Ling Chen, Yan-Ping Liu, Ming-Hua Zheng, Jing-Yi Jin. GSH-triggered release of anabasine in mitochondria for synergistic chemotherapy assisted by OATP transportation[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101565

PDF( 22388 KB)

GSH-triggered release of anabasine in mitochondria for synergistic chemotherapy assisted by OATP transportation

doi: 10.1016/j.jpha.2026.101565

a. Research Centre of Chemical Biology, Yanbian University, Yanji, Jilin, 133002, China;
b. Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, First Hospital of Jilin University, Jilin University, Changchun, 130021, China

Funds:

This work was supported by grant from the National Natural Science Foundation of China (Grant No.: 22367022). Dr. Ling-Li Wang thanks the financial support from the China Postdoctoral Science Foundation (Grant No.: 20250535).

Received Date: Jul. 30, 2025
Accepted Date: Jan. 27, 2026
Rev Recd Date: Jan. 25, 2026
Available Online: Jan. 30, 2026

Abstract

FullText(HTML)

References(5)

References

[1]	Q. Zhou, J. Xiang, N. S. Qiu, et al., Tumor abnormality-oriented nanomedicine design, Chem. Rev. 123 (2023) 10920-10989.
[2]	A. Saminathan, M. Zajac, P. Anees, et al., Organelle-level precision with next generation targeting technologies, Nat. Rev. Mater. 7 (2022) 355-371.
[3]	E. Zhang, S. Luo, X. Tan, et al., Mechanistic study of IR-780 dye as a potential tumor targeting and drug delivery agent, Biomaterials 35 (2014) 771-778.
[4]	H. Gan, X. Huang, X. Luo, et al., A mitochondria-targeted ferroptosis inducer activated by glutathione-responsive imaging and depletion for triple negative breast cancer theranostics, Adv. Healthc. Mater. 12 (2023), 2300220.
[5]	D. Mancias, X. Wang, S. P. Gygi, et al., Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy, Nature 509 (2014) 105-109.