The role of stem cells in the pharmacological assessment of nanoparticles

Sulaiman Mohammed Alnasser; Abdulaziz Khaled Aldoaiji; Rakan Abdulrahman Alharbi; Hussain Qassem Alhajjoj; Waleed Talal Aldebassi; Abdulrahman Ahmed Almaiman; Abdulelah Hussain Almutairi

doi:10.1016/j.jpha.2026.101547

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Sulaiman Mohammed Alnasser, Abdulaziz Khaled Aldoaiji, Rakan Abdulrahman Alharbi, Hussain Qassem Alhajjoj, Waleed Talal Aldebassi, Abdulrahman Ahmed Almaiman, Abdulelah Hussain Almutairi. The role of stem cells in the pharmacological assessment of nanoparticles[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101547

Citation:

Sulaiman Mohammed Alnasser, Abdulaziz Khaled Aldoaiji, Rakan Abdulrahman Alharbi, Hussain Qassem Alhajjoj, Waleed Talal Aldebassi, Abdulrahman Ahmed Almaiman, Abdulelah Hussain Almutairi. The role of stem cells in the pharmacological assessment of nanoparticles[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101547

Citation:

Sulaiman Mohammed Alnasser, Abdulaziz Khaled Aldoaiji, Rakan Abdulrahman Alharbi, Hussain Qassem Alhajjoj, Waleed Talal Aldebassi, Abdulrahman Ahmed Almaiman, Abdulelah Hussain Almutairi. The role of stem cells in the pharmacological assessment of nanoparticles[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2026.101547

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The role of stem cells in the pharmacological assessment of nanoparticles

doi: 10.1016/j.jpha.2026.101547

a. Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia;
b. College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia

Funds:

The Researchers would like to thank the Deanship of Graduate Studies and Scientific Research at Qassim University for financial support (QU-APC-2026)

Received Date: May 20, 2025
Accepted Date: Jan. 03, 2026
Rev Recd Date: Dec. 31, 2025
Available Online: Jan. 10, 2026

Abstract

Abstract

Stem cells aid in the pharmacological assessment of nanoparticles by serving as a human-relevant, dynamic, and scalable model. Their integration into nanoparticle research enhances toxicity screening and therapeutic optimization by evaluating absorption, distribution, metabolism, excretion and toxicity (ADMET) parameters across models ranging from simple in vitro cultures to complex organoids. They provide insights into how nanoparticles interact with biological systems, guiding the rational design of safer, more effective nanomedicines. Conventional in vitro and animal models often fall short in recapitulating human-specific responses, as they cannot fully capture the complex interactions between nanoparticles and biological systems. This limitation significantly reduces the predictive accuracy of toxicity and efficacy assessments. In contrast, stem cell-based models offer a transformative platform by providing physiologically relevant, patient-specific and organotypic systems which help overcome critical challenges such as species differences, limited cellular diversity, and ethical concerns associated with animal testing. This review examines the fundamentals of nanoparticle and stem cell interactions, ADMET profiling, and the immunomodulatory properties of nanoparticles, all of which are pivotal for comprehensive pharmacological assessment. The key challenges such as standardization, long-term safety, and regulatory compliance that hinder clinical translation are also discussed.
- Stem cells,
- Nanoparticles,
- ADMET,
- In vitro models,
- Organoids

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References(154)

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