Exploring the potential of natural products in treating alopecia areata

Baoli He; Yujia Weng; Peihua Luo; Zhifei Xu; Hao Yan; Bo Yang; Qiaojun He; Jiabin Lu; Xiaochun Yang

doi:10.1016/j.jpha.2025.101539

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Baoli He, Yujia Weng, Peihua Luo, Zhifei Xu, Hao Yan, Bo Yang, Qiaojun He, Jiabin Lu, Xiaochun Yang. Exploring the potential of natural products in treating alopecia areata[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101539

Citation:

Baoli He, Yujia Weng, Peihua Luo, Zhifei Xu, Hao Yan, Bo Yang, Qiaojun He, Jiabin Lu, Xiaochun Yang. Exploring the potential of natural products in treating alopecia areata[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101539

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Exploring the potential of natural products in treating alopecia areata

doi: 10.1016/j.jpha.2025.101539

Baoli He^a,b,
Yujia Weng^a,b,
Peihua Luo^a,c,
Zhifei Xu^a,c,
Hao Yan^a,c,
Bo Yang^a,c,d,
Qiaojun He^a,b,c,e,
Jiabin Lu^{a,b,c
,
,},
Xiaochun Yang^{a,b,c,e
,
,}

a. Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China;
b. Nanhu Brain-computer Interface Institute, Hangzhou, 311100, China;
c. Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China;
d. School of Medicine, Hangzhou City University, Hangzhou, 310015, China;
e. Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China

Funds:

This work was supported by grants from the Youth Fund of the National Natural Science Foundation of China (Grant No.: 82404960), and the National Key Research and Development Program (Program No.: 2020YFE0204300).

Received Date: Aug. 04, 2025
Accepted Date: Dec. 23, 2025
Rev Recd Date: Dec. 22, 2025
Available Online: Jan. 07, 2026

Abstract

Abstract

Alopecia areata (AA) is an autoimmune disorder characterized by sudden hair loss, affecting millions worldwide. Conventional synthetic drug treatments are often limited by side effects, driving interest in natural alternatives. This review highlights terpenoids, flavonoids, and polyphenols as promising natural compounds that effectively promote hair regrowth in AA. These phytochemicals exert therapeutic effects primarily by activating pro-anagenic signaling pathways, notably the Wnt/β-catenin and phosphoinositide 3-kinase-protein kinase B (PI3K-Akt) pathways, while inhibiting catagen-associated pathways such as transforming growth factor-β (TGF-β), and modulating immune dysregulation through the suppression of Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling. This review has detailed the mechanisms through which these compounds support hair follicle regeneration, restore immune balance, and reduce inflammation. Collectively, the evidence highlights the significant therapeutic potential of natural products for AA, underscoring the need for further translational research.
- Natural products,
- Alopecia areata,
- Hair follicle immune privilege,
- Phytochemicals

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References(149)

References

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