Total flavonoids of Litchi seed suppress liver cancer stem cell-like properties by inhibiting the SKP2/Shh signaling axis

Yuanshuo Wang; Xiaolan Li; Jiejun Fu; Shoushi Liu; Jie Hao; Zhiping Cheng; Songhua He; Xin Yang; Ronghua Jin; Jinjian Lu; Qinpei Lu; Qiuju Huang; Hongwei Guo

doi:10.1016/j.jpha.2025.101537

Article Contents

Article Navigation > Journal of Pharmaceutical Analysis > 2025 > Accepted Manu

Yuanshuo Wang, Xiaolan Li, Jiejun Fu, Shoushi Liu, Jie Hao, Zhiping Cheng, Songhua He, Xin Yang, Ronghua Jin, Jinjian Lu, Qinpei Lu, Qiuju Huang, Hongwei Guo. Total flavonoids of Litchi seed suppress liver cancer stem cell-like properties by inhibiting the SKP2/Shh signaling axis[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101537

Citation:

Yuanshuo Wang, Xiaolan Li, Jiejun Fu, Shoushi Liu, Jie Hao, Zhiping Cheng, Songhua He, Xin Yang, Ronghua Jin, Jinjian Lu, Qinpei Lu, Qiuju Huang, Hongwei Guo. Total flavonoids of Litchi seed suppress liver cancer stem cell-like properties by inhibiting the SKP2/Shh signaling axis[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101537

Citation:

Yuanshuo Wang, Xiaolan Li, Jiejun Fu, Shoushi Liu, Jie Hao, Zhiping Cheng, Songhua He, Xin Yang, Ronghua Jin, Jinjian Lu, Qinpei Lu, Qiuju Huang, Hongwei Guo. Total flavonoids of Litchi seed suppress liver cancer stem cell-like properties by inhibiting the SKP2/Shh signaling axis[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101537

PDF( 4743 KB)

Total flavonoids of Litchi seed suppress liver cancer stem cell-like properties by inhibiting the SKP2/Shh signaling axis

doi: 10.1016/j.jpha.2025.101537

Yuanshuo Wang^a,b,
Xiaolan Li^a,b,
Jiejun Fu^b,
Shoushi Liu^a,b,
Jie Hao^a,b,
Zhiping Cheng^a,b,
Songhua He^c,
Xin Yang^b,
Ronghua Jin^a,
Jinjian Lu^d,
Qinpei Lu^{a
,
,},
Qiuju Huang^{a
,
,},
Hongwei Guo^{a,b
,
,}

a. Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation & Pharmaceutical College, Guangxi Medical University, Nanning, 530021, China;
b. Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Guangxi Medical University, Nanning, 530021, China;
c. Guangxi Institute for Food and Drug Control, Nanning, 530021, China;
d. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, 999078, China

Funds:

This work was supported by the Guangxi Key R&

D Program (Project No.: AB23026137), the Innovation Project of Guangxi Graduate Education (Project No.: YCSW2024272) and the National Natural Science Foundation of China (Grant No.: 82360793).

Received Date: Jun. 10, 2025
Accepted Date: Dec. 20, 2025
Rev Recd Date: Dec. 17, 2025
Available Online: Dec. 22, 2025

Abstract

FullText(HTML)

References(5)

References

[1]	T.K. Lee, X. Guan, S. Ma, Cancer stem cells in hepatocellular carcinoma: From origin to clinical implications, Nat. Rev. Gastroenterol. Hepatol. 19 (2022) 26-44.
[2]	D. Cui, Z. Luo, X. Liu, et al., Combination of metabolomics and network pharmacology analysis to decipher the mechanisms of total flavonoids of Litchi seed against prostate cancer, J. Pharm. Pharmacol. 75 (2023) 951-968.
[3]	Y. Hu, G.K. Smyth, ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays, J. Immunol. Methods 347 (2009) 70-78.
[4]	J. Wu, H. Su, Z. Yu, et al., Skp2 modulates proliferation, senescence and tumorigenesis of glioma, Cancer Cell Int. 20 (2020), 71.
[5]	K.S. Jeng, C.F. Chang, I.S. Sheen, et al., Cellular and molecular biology of cancer stem cells of hepatocellular carcinoma, Int. J. Mol. Sci. 24 (2023), 1417.