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Wei Wei, Zhaoyuan Li, Bin Wang, Yang Liu, Yuxuan Sun, Dong Wen, Mei Rong, Pengcheng Huang, Yuwei Guo, Qiuling Wang, Zhihui Gao, Jianhe Wei. Pharmacological effects, classification, genetic and molecular studies of different chemotypes essential oil of Perilla frutescens (L.) Britt.: A review[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101454
Citation: Wei Wei, Zhaoyuan Li, Bin Wang, Yang Liu, Yuxuan Sun, Dong Wen, Mei Rong, Pengcheng Huang, Yuwei Guo, Qiuling Wang, Zhihui Gao, Jianhe Wei. Pharmacological effects, classification, genetic and molecular studies of different chemotypes essential oil of Perilla frutescens (L.) Britt.: A review[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101454

Pharmacological effects, classification, genetic and molecular studies of different chemotypes essential oil of Perilla frutescens (L.) Britt.: A review

doi: 10.1016/j.jpha.2025.101454
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This work was funded by National Key R&D Program of China (Grant number: 2022YFC3501504) , CAMS Innovation Fund for Medical Sciences(CIFMS) (grant no. 2023-I2M-2-006 and 2021-I2M-1-032).

  • Received Date: Mar. 19, 2025
  • Rev Recd Date: Sep. 15, 2025
  • Available Online: Sep. 18, 2025
  • Perilla frutescens (L.) Britton (P. frutescens) is a highly valuable medicinal plant known for a wide variety of chemotypes based on the components of its essential oils. The appropriate and secure medicinal use of P. frutescens has been severely limited due to the lack of chemotype classification standards and pharmacological studies. In this paper, a classification standard for essential oils in P. frutescens was proposed. The pharmacological activities of different chemotypes or their main components were summarized. Genetic and molecular studies related to the formation of different chemotypes were also reviewed. The molecular mechanism underlying the formation of P. frutescens chemotypes is also discussed to pave the way for the innovation of P. frutescens germplasms for medicinal use.
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      沈阳化工大学材料科学与工程学院 沈阳 110142

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