Citation: | Qiang Wang, Qiyao Nong, Junguo Zang, Meiyu Gao, Ying Zhang, Xinyuan Hao, Yuan Tian, Fengguo Xu, Pei Zhang. PFKM promotes chemoresistance in lung adenocarcinoma by regulating RAB8B mediated exosome release[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101450 |
[1] |
J.R. Molina, P. Yang, S.D. Cassivi, et al., Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship, Mayo Clin Proc 83 (2008) 584-594.
|
[2] |
C. Zappa, S.A. Mousa, Non-small cell lung cancer: current treatment and future advances, Transl Lung Cancer Res 5 (2016) 288-300.
|
[3] |
F.R. Hirsch, G.V. Scagliotti, J.L. Mulshine, et al., Lung cancer: current therapies and new targeted treatments, Lancet 389 (2017) 299-311.
|
[4] |
M.D. Siegelin, A.C. Borczuk, Epidermal growth factor receptor mutations in lung adenocarcinoma, Lab Invest 94 (2014) 129-137.
|
[5] |
M. Oudkerk, S. Liu, M.A. Heuvelmans, et al., Lung cancer LDCT screening and mortality reduction - evidence, pitfalls and future perspectives, Nat Rev Clin Oncol 18 (2021) 135-151.
|
[6] |
R.S. Herbst, D. Morgensztern, C. Boshoff, The biology and management of non-small cell lung cancer, Nature 553 (2018) 446-454.
|
[7] |
G.J. Riely, D.E. Wood, D.S. Ettinger, et al., Non-Small Cell Lung Cancer, Version 4.2024, NCCN Clinical Practice Guidelines in Oncology, J Natl Compr Canc Netw 22 (2024) 249-274.
|
[8] |
W. Fan, J. Huang, F. Tian, et al., m(6)A-Modified SNRPA Controls Alternative Splicing of ERCC1 Exon 8 to Induce Cisplatin Resistance in Lung Adenocarcinoma, Adv Sci (Weinh) 11 (2024) e2404609.
|
[9] |
C. Pan, B. Li, M.C. Simon, Moonlighting functions of metabolic enzymes and metabolites in cancer, Mol Cell 81 (2021) 3760-3774.
|
[10] |
H. Jeong, S. Kim, B.J. Hong, et al., Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis, Cancer Res 79 (2019) 795-806.
|
[11] |
Y. Zhang, H. Ma, L. Li, et al., Dual-Targeted Novel Temozolomide Nanocapsules Encapsulating siPKM2 Inhibit Aerobic Glycolysis to Sensitize Glioblastoma to Chemotherapy, Adv Mater 36 (2024) e2400502.
|
[12] |
M. Feng, Q. Jiao, Y. Ren, et al., The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironment, Cell Death Dis 15 (2024) 758.
|
[13] |
Y. He, X. Wang, W. Lu, et al., PGK1 contributes to tumorigenesis and sorafenib resistance of renal clear cell carcinoma via activating CXCR4/ERK signaling pathway and accelerating glycolysis, Cell Death Dis 13 (2022) 118.
|
[14] |
M. Liao, D. Yao, L. Wu, et al., Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer, Acta Pharm Sin B 14 (2024) 953-1008.
|
[15] |
Y. Zhou, F. Lin, T. Wan, et al., ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM, Theranostics 11 (2021) 5926-5938.
|
[16] |
W. Gao, M. Huang, X. Chen, et al., The role of S-nitrosylation of PFKM in regulation of glycolysis in ovarian cancer cells, Cell Death Dis 12 (2021) 408.
|
[17] |
J. Zhao, C. Yao, Y. Qin, et al., Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner, Cell Death Dis 15 (2024) 120.
|
[18] |
Q.F. Han, W.J. Li, K.S. Hu, et al., Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer, Mol Cancer 21 (2022) 207.
|
[19] |
N. Milman, L. Ginini, Z. Gil, Exosomes and their role in tumorigenesis and anticancer drug resistance, Drug Resist Updat 45 (2019) 1-12.
|
[20] |
Y. Zhang, X. Li, H. Chen, et al., Cancer Cell-Derived Exosomal miR-500a-3p Modulates Hepatic Stellate Cell Activation and the Immunosuppressive Microenvironment, Adv Sci (Weinh) (2024) e2404089.
|
[21] |
X. Wu, C. Ban, W. Deng, et al., Unveiling the PDK4-centered rituximab-resistant mechanism in DLBCL: the potential of the "Smart" exosome nanoparticle therapy, Mol Cancer 23 (2024) 144.
|
[22] |
M. Poggio, T. Hu, C.C. Pai, et al., Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory, Cell 177 (2019) 414-427 e413.
|
[23] |
D. Wang, C. Zhao, F. Xu, et al., Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2, Theranostics 11 (2021) 2860-2875.
|
[24] |
H. Wang, N. Li, Q. Liu, et al., Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer, Cancer Cell 41 (2023) 1345-1362 e1349.
|
[25] |
S. Li, Q. Xiao, J. Sun, et al., A new chemical derivatization reagent sulfonyl piperazinyl for the quantification of fatty acids using LC-MS/MS, Talanta 277 (2024) 126378.
|
[26] |
M. Boretto, N. Maenhoudt, X. Luo, et al., Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening, Nat Cell Biol 21 (2019) 1041-1051.
|
[27] |
J. Li, N. Gao, Z. Gao, et al., The Emerging Role of Exosomes in Cancer Chemoresistance, Front Cell Dev Biol 9 (2021) 737962.
|
[28] |
Y. Wei, D. Wang, F. Jin, et al., Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23, Nat Commun 8 (2017) 14041.
|
[29] |
P. Li, M. Su, M. Chatterjee, et al., Targeted analysis of sugar phosphates from glycolysis pathway by phosphate methylation with liquid chromatography coupled to tandem mass spectrometry, Anal Chim Acta 1221 (2022) 340099.
|
[30] |
B. Polonia, C.P.R. Xavier, J. Kopecka, et al., The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance, Cytokine Growth Factor Rev 73 (2023) 150-162.
|
[31] |
Y. Li, Y. Wen, Y. Li, et al., Rab10-CAV1 mediated intraluminal vesicle transport to migrasomes, Proc Natl Acad Sci U S A 121 (2024) e2319267121.
|
[32] |
T. Matsui, Y. Sakamaki, S. Nakashima, et al., Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells, Cell Rep 39 (2022) 110875.
|
[33] |
X. Wang, D. Qiao, L. Chen, et al., Chemotherapeutic drugs stimulate the release and recycling of extracellular vesicles to assist cancer cells in developing an urgent chemoresistance, Mol Cancer 18 (2019) 182.
|
[34] |
B. Wu, D.A. Liu, L. Guan, et al., Stiff matrix induces exosome secretion to promote tumour growth, Nat Cell Biol 25 (2023) 415-424.
|