The role of mitochondria transfer in cancer biological behavior, the immune system and therapeutic resistance

Xintong Lyu; Yangyang Yu; Yuanjun Jiang; Zhiyuan Li; Qiao Qiao

doi:10.1016/j.jpha.2024.101141

Volume 15 Issue 3

Apr. 2025

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Xintong Lyu, Yangyang Yu, Yuanjun Jiang, Zhiyuan Li, Qiao Qiao. The role of mitochondria transfer in cancer biological behavior, the immune system and therapeutic resistance[J]. Journal of Pharmaceutical Analysis, 2025, 15(3): 101141. doi: 10.1016/j.jpha.2024.101141

Citation:

Xintong Lyu, Yangyang Yu, Yuanjun Jiang, Zhiyuan Li, Qiao Qiao. The role of mitochondria transfer in cancer biological behavior, the immune system and therapeutic resistance[J]. Journal of Pharmaceutical Analysis, 2025, 15(3): 101141. doi: 10.1016/j.jpha.2024.101141

Citation:

Xintong Lyu, Yangyang Yu, Yuanjun Jiang, Zhiyuan Li, Qiao Qiao. The role of mitochondria transfer in cancer biological behavior, the immune system and therapeutic resistance[J]. Journal of Pharmaceutical Analysis, 2025, 15(3): 101141. doi: 10.1016/j.jpha.2024.101141

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The role of mitochondria transfer in cancer biological behavior, the immune system and therapeutic resistance

doi: 10.1016/j.jpha.2024.101141

a. Department of Radiation Oncology, First Hospital of China Medical University, Shenyang, 110001, China;
b. Department of Urology, First Hospital of China Medical University, Shenyang, 110001, China;
c. Department of Urology, Shengjing Hospital of China Medical University, Shenyang, 110001, China

Funds:

This study was supported by the National Natural Science Foundation of China (Grant No.: 82272749) and the Natural Science Foundation of Liaoning Province, China (Grant No.: 2022-MS-190).

Received Date: Jun. 21, 2024
Accepted Date: Nov. 03, 2024
Rev Recd Date: Oct. 14, 2024
Publish Date: Nov. 08, 2024

Abstract

Abstract

Mitochondria play a crucial role as organelles, managing several physiological processes such as redox balance, cell metabolism, and energy synthesis. Initially, the assumption was that mitochondria primarily resided in the host cells and could exclusively transmit from oocytes to offspring by a mechanism known as vertical inheritance of mitochondria. Recent scholarly works, however, suggest that certain cell types transmit their mitochondria to other developmental cell types via a mechanism referred to as intercellular or horizontal mitochondrial transfer. This review details the process of which mitochondria are transferred across cells and explains the impact of mitochondrial transfer between cells on the efficacy and functionality of cancer cells in various cancer forms. Specifically, we review the role of mitochondria transfer in regulating cellular metabolism restoration, excess reactive oxygen species (ROS) generation, proliferation, invasion, metastasis, mitophagy activation, mitochondrial DNA (mtDNA) inheritance, immune system modulation and therapeutic resistance in cancer. Additionally, we highlight the possibility of using intercellular mitochondria transfer as a therapeutic approach to treat cancer and enhance the efficacy of cancer treatments.
- Mitochondria transfer,
- Cancer biological behavior,
- Immune system,
- Therapeutic resistance

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References(90)

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