Targeted screening and profiling of massive components of colistimethate sodium by two-dimensional-liquid chromatography-mass spectrometry based on self-constructed compound database

doi: 10.1016/j.jpha.2024.101072

• Xuan Li^a,b , 
• Minwen Huang^a,c , 
• Yue-Mei Zhao^a,d , 
• Wenxin Liu^a , 
• Nan Hu^e , 
• Jie Zhou^f , 
• Zi-Yi Wang^b , 
• Sheng Tang^g , 
• Jian-Bin Pan^{h ,  ,}  , 
• Hian Kee Lee^{g,i ,  ,}  , 
• Yao-zuo Yuan^{a,c ,  ,}  , 
• Taijun Hang^b , 
• Hai-Wei Shi^{a,c ,  ,}  , 
• Hongyuan Chen^h

• a. Jiangsu Institute for Food and Drug Control, Nanjing, 210019, China;

• b. School of Pharmacy, China Pharmaceutical University, Nanjing, 211112, China;

• c. National Medical Products Administration Key Laboratory for Impurity Profile of Chemical Drugs, Nanjing, 210019, China;

• d. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210046, China;

• e. Agilent Technologies Inc., Beijing, 100102, China;

• f. Jiangsu Zhengda Tianqing Pharmaceutical Group Co., Ltd., Lianyungang, Jiangsu, 222006, China;

• g. School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, 212003, China;

• h. School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210046, China;

• i. Department of Chemistry, National University of Singapore, Singapore, 117543, Singapore