Eco-friendly high-throughput screening of cephalosporins impurities: Utilizing 2D-carbon microfiber fractionation system combined with quadrupole time of flight high-resolution mass spectrometer

Lei Yang; Yan Wang; Zhao Wang; Meiyu Cui; Ruolan Jin; Hai-Bo Shang; Donghao Li

doi:10.1016/j.jpha.2023.11.007

Volume 14 Issue 5

May 2024

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Lei Yang, Yan Wang, Zhao Wang, Meiyu Cui, Ruolan Jin, Hai-Bo Shang, Donghao Li. Eco-friendly high-throughput screening of cephalosporins impurities: Utilizing 2D-carbon microfiber fractionation system combined with quadrupole time of flight high-resolution mass spectrometer[J]. Journal of Pharmaceutical Analysis, 2024, 14(5): 100900. doi: 10.1016/j.jpha.2023.11.007

Citation:

Lei Yang, Yan Wang, Zhao Wang, Meiyu Cui, Ruolan Jin, Hai-Bo Shang, Donghao Li. Eco-friendly high-throughput screening of cephalosporins impurities: Utilizing 2D-carbon microfiber fractionation system combined with quadrupole time of flight high-resolution mass spectrometer[J]. Journal of Pharmaceutical Analysis, 2024, 14(5): 100900. doi: 10.1016/j.jpha.2023.11.007

Citation:

Lei Yang, Yan Wang, Zhao Wang, Meiyu Cui, Ruolan Jin, Hai-Bo Shang, Donghao Li. Eco-friendly high-throughput screening of cephalosporins impurities: Utilizing 2D-carbon microfiber fractionation system combined with quadrupole time of flight high-resolution mass spectrometer[J]. Journal of Pharmaceutical Analysis, 2024, 14(5): 100900. doi: 10.1016/j.jpha.2023.11.007

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Eco-friendly high-throughput screening of cephalosporins impurities: Utilizing 2D-carbon microfiber fractionation system combined with quadrupole time of flight high-resolution mass spectrometer

doi: 10.1016/j.jpha.2023.11.007

Lei Yang^a,
Yan Wang^b,
Zhao Wang^b,
Meiyu Cui^b,
Ruolan Jin^b,
Hai-Bo Shang^{b
,
,},
Donghao Li^{a,b
,
,}

a. College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China;
b. Department of Chemistry, Interdisciplinary Program of Biological Functional Molecules, College of Integration Science, Yanbian University, Yanji, Jilin, 133002, China

Funds:

This study was supported by a grant from the National Natural Science Foundation of China (Grant Nos.: 22176164 and 21904113) and the Higher Education Discipline Innovation Project, China (Project No.: D18012).

Received Date: Apr. 28, 2023
Accepted Date: Nov. 15, 2023
Rev Recd Date: Oct. 25, 2023
Publish Date: May 30, 2024

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References(5)

References

[1]	J. Li, D. Zhang, C. Hu, Characterization of impurities in cefpodoxime proxetil using LC-MSn, Acta Pharm. Sin. B 4 (2014) 322-332.
[2]	X.Y. Duan, Y. Zhang, J.Q. Yan, et al., Progress in pretreatment and analysis of cephalosporins: An update since 2005, Crit. Rev. Anal. Chem. 51 (2021) 55-86.
[3]	European Pharmacopoeia, 10th Edition. Council of Europe, Strasbourg, 2020.
[4]	R.D. Stanelle, L.C. Sander, R.K. Marcus, Hydrodynamic flow in capillary-channel fiber columns for liquid chromatography, J. Chromatogr. A 1100 (2005) 68-75.
[5]	I.D. Souza, I.G.C. Oliveira, M.E.C. Queiroz, Innovative extraction materials for fiber-in-tube solid phase microextraction: A review, Anal. Chim. Acta 1165 (2021), 238110.