3D Raman mapping as an analytical tool for investigating the coatings of coated drug particles

Georgia Koutentaki; Pavel Krýsa; Dan Trunov; Tomáš Pekárek; Markéta Pišlová; Miroslav Šoóš

doi:10.1016/j.jpha.2023.02.004

Volume 13 Issue 3

Mar. 2023

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Georgia Koutentaki, Pavel Krýsa, Dan Trunov, Tomáš Pekárek, Markéta Pišlová, Miroslav Šoóš. 3D Raman mapping as an analytical tool for investigating the coatings of coated drug particles[J]. Journal of Pharmaceutical Analysis, 2023, 13(3): 276-286. doi: 10.1016/j.jpha.2023.02.004

Citation:

Georgia Koutentaki, Pavel Krýsa, Dan Trunov, Tomáš Pekárek, Markéta Pišlová, Miroslav Šoóš. 3D Raman mapping as an analytical tool for investigating the coatings of coated drug particles[J]. Journal of Pharmaceutical Analysis, 2023, 13(3): 276-286. doi: 10.1016/j.jpha.2023.02.004

Citation:

Georgia Koutentaki, Pavel Krýsa, Dan Trunov, Tomáš Pekárek, Markéta Pišlová, Miroslav Šoóš. 3D Raman mapping as an analytical tool for investigating the coatings of coated drug particles[J]. Journal of Pharmaceutical Analysis, 2023, 13(3): 276-286. doi: 10.1016/j.jpha.2023.02.004

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3D Raman mapping as an analytical tool for investigating the coatings of coated drug particles

doi: 10.1016/j.jpha.2023.02.004

a. Department of Chemical Engineering, University of Chemistry and Technology Prague, Prague 6, 16628, Czech Republic;
b. Zentiva, k.s., Prague 10, 10237, Czech Republic

Funds:

This work was financially supported by specific university research (Grant No.: A1_FCHI_2022_006). We also thank the research platform “Pharmaceutical Applied Research Center” (PARC) (Prague, Czech Republic) for the support in various parts of this project.

Received Date: Sep. 04, 2022
Accepted Date: Feb. 09, 2023
Rev Recd Date: Feb. 03, 2023
Publish Date: Feb. 16, 2023

Abstract

Abstract

The properties of dry-coated paracetamol particles (fast-dissolving model drug) with carnauba wax particles as the coating agent (dissolution retardant) were investigated. Raman mapping technique was used to non-destructively examine the thickness and homogeneity of coated particles. The results showed that the wax existed in two forms on the surface of the paracetamol particles, forming a porous coating layer: i) whole wax particles on the surface of paracetamol and glued together with other wax surface particles, and ii) deformed wax particles spread on the surface. Regardless of the final particle size fraction (between 100 and 800 μm), the coating thickness had high variability, with average thickness of 5.9 ± 4.2 μm. The ability of carnauba wax to decrease the dissolution rate of paracetamol was confirmed by dissolution of powder and tablet formulations. The dissolution was slower for larger coated particles. Tableting further reduced the dissolution rate, clearly indicating the impact of subsequent formulation processes on the final quality of the product.
- Raman mapping,
- Dry-coating,
- Dissolution,
- Particle coating thickness,
- Polymers

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References(50)

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