Volume 12 Issue 3
Jun.  2022
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Article Navigation >  Journal of Pharmaceutical Analysis  > 2022  >  12(3): 394-405
Akansha Chauhan, Asim Ul Islam, Hridayesh Prakash, Sandhya Singh. Phytochemicals targeting NF-κB signaling:Potential anti-cancer interventions[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 394-405. doi: 10.1016/j.jpha.2021.07.002
Citation: Akansha Chauhan, Asim Ul Islam, Hridayesh Prakash, Sandhya Singh. Phytochemicals targeting NF-κB signaling:Potential anti-cancer interventions[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 394-405. doi: 10.1016/j.jpha.2021.07.002
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Phytochemicals targeting NF-κB signaling:Potential anti-cancer interventions

doi: 10.1016/j.jpha.2021.07.002

  • a. Amity Institute of Physiology &Allied Sciences, Amity University, Noida, Uttar Pradesh, India;

  • b. Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India;

  • c. Amity Institute of Virology &Immunology, Amity University, Noida, Uttar Pradesh, India

Funds:

The author is thankful to the lab mates Mr. Aniket Angira and Ms. Pooja Singh for their support in completion of this review article.

  • Received Date: Oct. 17, 2020
  • Accepted Date: Jul. 04, 2021
  • Rev Recd Date: Jul. 03, 2021
  • Publish Date: Jul. 06, 2021
    Abstract
  • Nuclear factor κB (NF-κB) is a ubiquitous regulator of the signalome and is indispensable for various biological cell functions. NF-κB consists of five transcription factors that execute both cytoplasmic and nuclear signaling processes in cells. NF-κB is the only signaling molecule that governs both pro- and anti-apoptotic, and pro- and anti-inflammatory responses. This is due to the canonical and non-canonical components of the NF-κB signaling pathway. Together, these pathways orchestrate cancer-related inflammation, hyperplasia, neoplasia, and metastasis. Non-canonical NF-κB pathways are particularly involved in the chemoresistance of cancer cells. In view of its pivotal role in cancer progression, NF-κB represents a potentially significant therapeutic target for modifying tumor cell behavior. Several phytochemicals are known to modulate NF-κB pathways through the stabilization of its inhibitor, IκB, by inhibiting phosphorylation and ubiquitination thereof. Several natural pharmacophores are known to inhibit the nuclear translocation of NF-κB and associated pro-inflammatory responses and cell survival pathways. In view of this and the high degree of specificity exhibited by various phytochemicals for the NF-κB component, we herein present an in-depth overview of these phytochemicals and discuss their mode of interaction with the NF-κB signaling pathways for controlling the fate of tumor cells for cancer-directed interventions.
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