Curcumin encapsulated dual cross linked sodium alginate/montmorillonite polymeric composite beads for controlled drug delivery

O. Sreekanth Reddy; M.C.S. Subha; T. Jithendra; C. Madhavi; K. Chowdoji Rao

doi:10.1016/j.jpha.2020.07.002

Volume 11 Issue 2

Apr. 2021

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O. Sreekanth Reddy, M.C.S. Subha, T. Jithendra, C. Madhavi, K. Chowdoji Rao. Curcumin encapsulated dual cross linked sodium alginate/montmorillonite polymeric composite beads for controlled drug delivery[J]. Journal of Pharmaceutical Analysis, 2021, 11(2): 191-199. doi: 10.1016/j.jpha.2020.07.002

Citation:

O. Sreekanth Reddy, M.C.S. Subha, T. Jithendra, C. Madhavi, K. Chowdoji Rao. Curcumin encapsulated dual cross linked sodium alginate/montmorillonite polymeric composite beads for controlled drug delivery[J]. Journal of Pharmaceutical Analysis, 2021, 11(2): 191-199. doi: 10.1016/j.jpha.2020.07.002

Citation:

O. Sreekanth Reddy, M.C.S. Subha, T. Jithendra, C. Madhavi, K. Chowdoji Rao. Curcumin encapsulated dual cross linked sodium alginate/montmorillonite polymeric composite beads for controlled drug delivery[J]. Journal of Pharmaceutical Analysis, 2021, 11(2): 191-199. doi: 10.1016/j.jpha.2020.07.002

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Curcumin encapsulated dual cross linked sodium alginate/montmorillonite polymeric composite beads for controlled drug delivery

doi: 10.1016/j.jpha.2020.07.002

a. Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, 515003, India;
b. Department of Polymer Science and Technology, Sri Krishnadevaraya University, Ananthapuramu, 515003, India

Funds:

The authors C. Madhavi and K. Chowdoji Rao thank UGC–BSR, New Delhi, India, for the financial support provided.

Received Date: May 30, 2019
Accepted Date: Jul. 05, 2020
Rev Recd Date: Sep. 30, 2019
Publish Date: Aug. 04, 2020

Abstract

Abstract

The aim of the present work is fabrication of dual cross linked sodium alginate (SA)/montmorillonite (MMT) microbeads as a potential drug vehicle for extended release of curcumin (CUR). The microbeads were prepared using in situ ion-exchange followed by simple ionotropic gelation technique. The developed beads were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (X-RD) and scanning electron microscopy (SEM). The effect of MMT on encapsulation efficiency of CUR and intercalation kinetics was investigated. Dynamic swelling study and in vitro release study were investigated in simulated intestinal fluid (pH 7.4) and simulated gastric fluid (pH 1.2) at 37 °C. Results suggested that both the swelling and in vitro release studies were influenced by the pH of test media, which might be suitable for intestinal drug delivery. The release mechanism was analyzed by fitting the release data into Korsmeyer-Peppas equation.
- Curcumin,
- Sodium alginate,
- Montmorillonite,
- Microbeads,
- Drug delivery

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References(33)

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