Volume 1 Issue 4
Nov.  2011
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Article Contents
Yan Li, Xiao-Rong Liu, Xiao-Hui Ning, Can-Can Huang, Jian-Bin Zheng, Jun-Cai Zhang. An ionic liquid supported CeO2 nanoparticles-carbon nanotubes composite-enhanced electrochemical DNA-based sensor for the detection of Pb2+[J]. Journal of Pharmaceutical Analysis, 2011, 01(4): 258-263. doi: 10.1016/j.jpha.2011.09.001
Citation: Yan Li, Xiao-Rong Liu, Xiao-Hui Ning, Can-Can Huang, Jian-Bin Zheng, Jun-Cai Zhang. An ionic liquid supported CeO2 nanoparticles-carbon nanotubes composite-enhanced electrochemical DNA-based sensor for the detection of Pb2+[J]. Journal of Pharmaceutical Analysis, 2011, 01(4): 258-263. doi: 10.1016/j.jpha.2011.09.001

An ionic liquid supported CeO2 nanoparticles-carbon nanotubes composite-enhanced electrochemical DNA-based sensor for the detection of Pb2+

doi: 10.1016/j.jpha.2011.09.001
Funds:

the National Science Foundations of China

the Specialized Research Fund for the Doctoral Program of Higher Education of China

the Natural Science Basic Research Plan in Shaanxi Province of China

the Education Department of Shaanxi Province

the NWU Graduate Innovation and Creativity Funds

  • Publish Date: Nov. 10, 2011
  • An electrochemical sensor incorporating a signal enhancement for the determination of lead (Ⅱ) ions (Pb2+) was designed on the basis of the thrombin-binding aptamer (TBA) as a molecular recognition element and ionic liquid supported cerium oxide (CeO2) nanoparticles-carbon nanotubes composite modification. The composite comprises nanoparticles CeO2, multi-wall carbon nanotubes (MWNTs)and hydrophobic room temperature ionic liquid (RTIL) l-ethyl-3-methylimidazolium tetrafluoroborate (EM1MBF4). The electrochemical sensors were fabricated by immersing the CeO2-MWNTs-EMIMBF4 modified glassy carbon electrode (GCE) into the solution of TBA probe. In the presence of Pb2+, the TBA probe could form stable G-quartet structure by the specific binding interactions between Pb2+ and TBA. The TBA-bound Pb2+ can be electrochemically reduced, which provides a readout signal for quantitative detection of Pb2+. The reduction peak current is linearly related to the concentration of Pb2+ from 1.0 × 10 8 M to 1.0 × 10-5 M with a detection limit of 5 × 109 M. This work demonstrates that the CeO2-MWNTs-EMIMBF4 nanocomposite modified GCE provides a promising platform for immobilizing the TBA probe and enhancing the sensitivity of the DNA-based sensors.
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