Single-cell and spatially resolved omics has made it possible to understand the cell composition, molecular architecture, and functional details of tissue from both cellular and spatial dimensions. Such a refined methodology paves the way to an intricate understanding of cellular heterogeneity, regulation, and dynamics, bearing the promise of unearthing previously unexplored disease mechanisms. Probing individual cells can lead to the identification of rare cellular phenotypes, exposure of intra-cellular genetic and epigenetic disparities, and the ability to trace the roots of disease. Furthermore, spatially resolved omics lends power to paint a biological process within its spatial milieu, contributing knowledge relating to the interplay among distinct cell types. Based on these state-of-art technologies, this issue mainly focuses on the detection of the following objectives: (1) New technology, analysis, resource and case study for single-cell and spatially resolved omics; (2) Development and integration of multi-modal omics; (3) New computational methods and algorithms.

Edited by Prof. Xiaohui Fan - College of Pharmaceutical Sciences, Innovation Center of Yangtze River Delta, Zhejiang University, Hangzhou, 310058, China

Pages 689-830 (July 2023)