Volume 10 Issue 3
Jun.  2020
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Wilson Z. Shou. Current status and future directions of high-throughput ADME screening in drug discovery[J]. Journal of Pharmaceutical Analysis, 2020, 10(3): 201-208.
Citation: Wilson Z. Shou. Current status and future directions of high-throughput ADME screening in drug discovery[J]. Journal of Pharmaceutical Analysis, 2020, 10(3): 201-208.

Current status and future directions of high-throughput ADME screening in drug discovery

  • Publish Date: Jun. 15, 2020
  • During the last decade high-throughput in vitro absorption, distribution, metabolism and excretion (HT-ADME) screening has become an essential part of any drug discovery effort of synthetic molecules. The conduct of HT-ADME screening has been"industrialized"due to the extensive development of software and automation tools in cell culture, assay incubation, sample analysis and data analysis. The HT-ADME assay portfolio continues to expand in emerging areas such as drug-transporter interactions, early soft spot identification, and ADME screening of peptide drug candidates. Additionally, thanks to the very large and high-quality HT-ADME data sets available in many biopharma companies, in silico prediction of ADME properties using machine learning has also gained much momentum in recent years. In this re-view, we discuss the current state-of-the-art practices in HT-ADME screening including assay portfolio, assay automation, sample analysis, data processing, and prediction model building. In addition, we also offer perspectives in future development of this exciting field.
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