Volume 7 Issue 2
Apr.  2017
Turn off MathJax
Article Contents
Abstract
References
Article Navigation >  Journal of Pharmaceutical Analysis  > 2017  >  7(2): 134-140
S. Dey, S. Subhasis Patro, N. Suresh Babu, P.N. Murthy, S.K. Panda. Development and validation of a stability-indicating RP–HPLC method for estimation of atazanavir sulfate in bulk[J]. Journal of Pharmaceutical Analysis, 2017, 7(2): 134-140.
Citation: S. Dey, S. Subhasis Patro, N. Suresh Babu, P.N. Murthy, S.K. Panda. Development and validation of a stability-indicating RP–HPLC method for estimation of atazanavir sulfate in bulk[J]. Journal of Pharmaceutical Analysis, 2017, 7(2): 134-140.
shu

Development and validation of a stability-indicating RP–HPLC method for estimation of atazanavir sulfate in bulk

  • Dr. B.C. Roy College of Pharmacy & Al ied Health Sciences, Meghnad Saha Sarani, Bidhannagar, Durgapur 713206, West Bengal, India

  • Royal College of Pharmacy and Health Sciences, Dist.-Ganjam, Berhampur 760002, Orissa, India

Funds:

The authors are grateful to the principal of Royal College of Pharmacy and Health Sciences, Berhampur, Orissa, for providing the facilities for working and also to the laboratory assistance

  • Publish Date: Apr. 10, 2017
    Abstract
  • A stability-indicating reverse phase–high performance liquid chromatography (RP–HPLC) method was developed and validated for the determination of atazanavir sulfate in tablet dosage forms using C18 column Phenomenix (250 mm×4.6 mm, 5μm) with a mobile phase consisting of 900 mL of HPLC grade methanol and 100 mL of water of HPLC grade. The pH was adjusted to 3.55 with acetic acid. The mobile phase was sonicated for 10 min and filtered through a 0.45μm membrane filter at a flow rate of 0.5 mL/min. The detection was carried out at 249 nm and retention time of atazanavir sulfate was found to be 8.323 min. Linearity was observed from 10 to 90μg/mL (coefficient of determination R2 was 0.999) with equation, y=23.427x+37.732. Atazanavir sulfate was subjected to stress conditions including acidic, alkaline, oxidation, photolysis and thermal degradation, and the results showed that it was more sensitive towards acidic degradation. The method was validated as per ICH guidelines.
    • FullText(HTML)
    • References(0)
    • Relative Articles

  • Relative Articles

    • Supplements(0)
    • Cited By

  • Cited by

    Periodical cited type(19)

    1. Deshpande, M., Shaikh, F., Sable, V. et al. New Stability Indicating RP-HPLC Method for Estimation of the Drug Molnupiravir. International Journal of Pharmaceutical Quality Assurance, 2023, 14(1): 149-158. doi:10.25258/ijpqa.14.1.26
    2. Chate, S.G., Birajdar, A.S. STABILITY INDICATING RP-HPLC PDA ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF BESIFLOXACIN HYDROCHLORIDE IN BULK AND FORMULATION. Indian Drugs, 2022, 59(11): 54-64. doi:10.53879/id.59.11.12823
    3. Shirode, A.R., Patil, P.N., Dhas, U.R. et al. STUDIES IN DEVELOPMENT, VALIDATION AND APPLICATION OF ANALYTICAL RP-HPLC METHOD FOR QUANTITATIVE ESTIMATION OF GLIPIZIDE FROM ITS BULK AND FORMULATION. Indian Drugs, 2022, 59(9): 56-65. doi:10.53879/id.59.09.12906
    4. Bordoloi, R., Ahmed, A.B., Baishya, H. Development and Validation of RP-UHPLC Method for Quantification of Gliclazide in Bulk and Pharmaceutical Dosage Form Using Quality-by-Design (QbD) Approach: A Shifting Paradigm. Chromatographia, 2022, 85(8): 719-732. doi:10.1007/s10337-022-04175-7
    5. Gurumukhi, V.C., Bari, S.B. Quantification and Validation of Stability-Indicating RP-HPLC Method for Efavirenz in Bulk and Tablet Dosage Form using Quality by Design (QbD): A Shifting Paradigm. Journal of Chromatographic Science, 2022, 60(2): 143-156. doi:10.1093/chromsci/bmab061
    6. Davies, K.R., Jones, B., Terashima, C. et al. Photocatalytic Water Pollutant Treatment: Fundamental, Analysis and Benchmarking. Nanostructured Materials for Environmental Applications, 2021. doi:10.1007/978-3-030-72076-6_16
    7. Nolay, F., Sevin, E., Létévé, M. et al. First step to the improvement of the blood brain barrier passage of atazanavir encapsulated in sustainable bioorganic vesicles. International Journal of Pharmaceutics, 2020. doi:10.1016/j.ijpharm.2020.119604
    8. Saha, C., Gupta, N.V., Chandan, R.S. Development and validation of a UPLC-MS method for determination of atazanavir sulfate by the "analytical quality by design" approach. Acta Pharmaceutica, 2020, 70(1): 17-33. doi:10.2478/acph-2020-0008
    9. Nadaf, S., Killedar, S. Development and validation of RP–HPLC method for estimation of curcumin from nanocochleates and its application in in–vivo pharmacokinetic study. Acta Chimica Slovenica, 2020, 67(4): 1100-1110. doi:10.17344/acsi.2020.5892
    10. Rapalli, V.K., Singhvi, G., Gorantla, S. et al. Stability indicating liquid chromatographic method for simultaneous quantification of betamethasone valerate and tazarotene in in vitro and ex vivo studies of complex nanoformulation. Journal of Separation Science, 2019, 42(22): 3413-3420. doi:10.1002/jssc.201900538
    11. Bhatta, R.G., Kotappa, S.B.B., Rudragangaiah, S. Quantification of rasagiline mesylate by stability indicating RP-HPLC method: Development and validation. Journal of Applied Pharmaceutical Science, 2019, 9(9): 059-065. doi:10.7324/JAPS.2019.90908
    12. Luong, T.T.M., Wang, W.-W., Zhang, F. et al. Structure-antifungal relationships and preventive effects of 1-(2, 4-dihydroxyphenyl)-2-methylpropan-1-one derivatives as potential inhibitors of class-II fructose-1, 6-bisphosphate aldolase. Pesticide Biochemistry and Physiology, 2019. doi:10.1016/j.pestbp.2019.05.016
    13. Pradhan, M., Alexander, A., Ajazuddin Development and validation of a robust RP-HPLC method for analysis of calcipotriol in pharmaceutical dosage form. Research Journal of Pharmacy and Technology, 2019, 12(2): 579-583. doi:10.5958/0974-360X.2019.00103.3
    14. Basilua, J.M., Sawoo, O., Mangin, I. et al. Higher atazanavir plasma exposure in rats is associated with gut microbiota changes induced by cotrimoxazole. Current Drug Metabolism, 2019, 20(11): 898-906. doi:10.2174/1389200220666191023105609
    15. Anitha, G., Pandey, V.P. Simultaneous high-performance liquid chromatography determination of non-nucleoside reverse transcriptase inhibitor and protease inhibitors: Global optimization Technique. Asian Journal of Pharmaceutics, 2018, 12(4): 303-311.
    16. Thomas, M.B., Gnanadhas, D.P., Dash, P.K. et al. Modulating cellular autophagy for controlled antiretroviral drug release. Nanomedicine, 2018, 13(17): 2139-2154. doi:10.2217/nnm-2018-0224
    17. Ali, S.I., Razvi, N., Hasan, S.M.F. Development and validation of HPLC method for the determination of pioglitazone in human plasma. Pakistan Journal of Pharmaceutical Sciences, 2018, 31(4): 1489-1494.
    18. Kasula, P., Kumara, K.V.N. Simultaneous estimation of atazanavir sulfate and ritonavir in marketed formulations - UV spectroscopic three wavelength method. Indian Drugs, 2018, 55(3): 58-61.
    19. Narendra, A., Annapurna, M.M. Study of forced degradation behavior of atazanavir. Research Journal of Pharmacy and Technology, 2018, 11(8): 3693-3697. doi:10.5958/0974-360X.2018.00678.9

    Other cited types(2)

  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-062024-072024-082024-092024-102024-112024-122025-012025-022025-032025-042025-0505101520
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 32.5 %FULLTEXT: 32.5 %META: 65.7 %META: 65.7 %PDF: 1.8 %PDF: 1.8 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 9.6 %其他: 9.6 %Algeria: 0.9 %Algeria: 0.9 %China: 57.9 %China: 57.9 %India: 6.0 %India: 6.0 %Italy: 0.9 %Italy: 0.9 %Other: 0.9 %Other: 0.9 %United States: 23.9 %United States: 23.9 %其他AlgeriaChinaIndiaItalyOtherUnited States

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (219) PDF downloads(6) Cited by(21)
    Proportional views
    Related

    Copyright © Journal of Pharmaceutical Analysis

    E-mail: jpasubmit@126.com;  jpaeditor@xjtu.edu.cn   Tel:+86-029-88960092

    Address: Western China Science and Technology Innovation Harbour, Xixian New Area, Xi’an, 712000, China

    Email alert RSS

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return