Suleiman Ahmed Suleiman, Fan Song, Mengxiang Su, Taijun Hang, Min Song. Analysis of bacitracin and its related substances by liquid chromatography tandem mass spectrometry[J]. Journal of Pharmaceutical Analysis, 2017, 7(1): 48-55.
Citation: Suleiman Ahmed Suleiman, Fan Song, Mengxiang Su, Taijun Hang, Min Song. Analysis of bacitracin and its related substances by liquid chromatography tandem mass spectrometry[J]. Journal of Pharmaceutical Analysis, 2017, 7(1): 48-55.

Analysis of bacitracin and its related substances by liquid chromatography tandem mass spectrometry

  • Publish Date: Feb. 10, 2017
  • A suitable liquid chromatography quadrupole time-of-flight mass spectrometric (LC–Q-TOF–MS) method was developed for separation and characterization of related substances in bacitracin test drug. The separation was performed on LiChrospher RP-18 column using methanol as mobile phase A and 0.2% ammonium acetate buffer solution as mobile phase B in gradient elution. A total of 12 related substances were detected through high resolution mass spectrometric determination in a positive electrospray ionization mode. They were identified as co-existing active components and degradation products of bacitracin through the analysis and elucidation of both the protonated parents and the product ions of all the related substances and their fragmentation pathways were also proposed.
  • Relative Articles

  • Cited by

    Periodical cited type(18)

    1. Xu, F., Yu, J., Wu, Y. Optimal conditions for determination of bacitracin, bacitracin zinc and bacitracin methylene disalicylate in animal feed by ultra-performance liquid tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2024, 1243: 124234. doi:10.1016/j.jchromb.2024.124234
    2. Buijs, N.P., Vlaming, H.C., Kotsogianni, I. et al. A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens. Proceedings of the National Academy of Sciences of the United States of America, 2024, 121(29): e2315310121. doi:10.1073/pnas.2315310121
    3. Chepchumba, B., Asudi, G.O., Katana, J. et al. Isolation of phages against Streptococcus species in the oral cavity for potential control of dental diseases and associated systemic complications. Archives of Microbiology, 2024, 206(4): 175. doi:10.1007/s00203-024-03897-6
    4. Abdel-Lateef, M.A., Darwish, I.A., H. Othman, M. et al. Spectrofluorimetric detection of bacitracin zinc in different water samples based on its derivatization with o-phthalaldehyde and 2-mercaptoethanol. Spectroscopy Letters, 2024. doi:10.1080/00387010.2024.2444382
    5. Abdel-Lateef, M.A., katamesh, N.S., Abdelbary, E. et al. Implementation of different fluorogenic condensation reactions for the spectrofluorimetric detection of the banned growth promoter, bacitracin, in water samples: assessment of the greenness of methods. Chemical Papers, 2024. doi:10.1007/s11696-024-03753-3
    6. Buijs, N.P., Matheson, E.J., Cochrane, S.A. et al. Targeting membrane-bound bacterial cell wall precursors: a tried and true antibiotic strategy in nature and the clinic. Chemical Communications, 2023, 59(50): 7685-7703. doi:10.1039/d3cc01070h
    7. Buijs, N., Vlaming, H.C., van Haren, M.J. et al. Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups. ChemBioChem, 2022, 23(24): e202200547. doi:10.1002/cbic.202200547
    8. Jin, P., Tan, Z., Wang, H. et al. Antimicrobial effect of Bacillus licheniformis HN-5 bacitracin A on rice pathogen Pantoea ananatis. BioControl, 2021, 66(2): 249-257. doi:10.1007/s10526-020-10052-9
    9. Zhang, H., Sun, N., Luo, W. et al. Structure elucidation of new kinds of bacitracin sulfonic acid based on high performance liquid chromatography-quadrupole time of flight-tandem mass spectrometry. International Journal of Mass Spectrometry, 2021, 461: 116499. doi:10.1016/j.ijms.2020.116499
    10. Covas, C., Almeida, B., Esteves, A.C. et al. Peptone from casein, an antagonist of nonribosomal peptide synthesis: a case study of pedopeptins produced by Pedobacter lusitanus NL19. New Biotechnology, 2021, 60: 62-71. doi:10.1016/j.nbt.2020.07.006
    11. Li, J.-Y., Gao, T.-T., Wang, Q. Comparative and Functional Analyses of Two Sequenced Paenibacillus polymyxa Genomes Provides Insights Into Their Potential Genes Related to Plant Growth-Promoting Features and Biocontrol Mechanisms. Frontiers in Genetics, 2020, 11: 564939. doi:10.3389/fgene.2020.564939
    12. Na, G., Hu, X., Yang, J. et al. Colloidal gold-based immunochromatographic strip assay for the rapid detection of bacitracin zinc in milk. Food Chemistry, 2020, 327: 126879. doi:10.1016/j.foodchem.2020.126879
    13. Bladek, T., Szymanek-Bany, I., Posyniak, A. Determination of polypeptide antibiotic residues in food of animal origin by ultra-high-performance liquid chromatography-tandem mass spectrometry. Molecules, 2020, 25(14): 3261. doi:10.3390/molecules25143261
    14. Byzova, N.A., Serchenya, T.S., Vashkevich, I.I. et al. Lateral flow immunoassay for rapid qualitative and quantitative control of the veterinary drug bacitracin in milk. Microchemical Journal, 2020, 156: 104884. doi:10.1016/j.microc.2020.104884
    15. Qin, F., Zhang, H., Liu, H. et al. High Performance Liquid Chromatography-Quadrupole/Time of Flight–Tandem Mass Spectrometry for the Characterization of Components in Bacitracin. Chromatographia, 2020, 83(5): 647-662. doi:10.1007/s10337-020-03882-3
    16. Vashkevich, I.I., Yastrebova, A.A., Kuprienko, O.S. et al. Enzyme immunoassay systems and a reagent kit for the determination of bacitracin in foods. Proceedings of the National Academy of Sciences of Belarus, Chemical Series, 2020, 56(3): 318-332. doi:10.29235/1561-8331-2020-56-3-318-332
    17. Patel, M., Kumar, R., Kishor, K. et al. Pharmaceuticals of emerging concern in aquatic systems: Chemistry, occurrence, effects, and removal methods. Chemical Reviews, 2019, 119(6): 3510-3673. doi:10.1021/acs.chemrev.8b00299
    18. Zhang, H.-Z., Qin, F., Liu, H. Analysis of the Related Substances and Content of Effective Bacitracin by HPLC Combined with Component Preparation | [HPLC结合组分制备分析杆菌肽中的有关物质及有效组分含量]. Chinese Pharmaceutical Journal, 2018, 53(23): 2041-2046. doi:10.11669/cpj.2018.23.012

    Other cited types(1)

  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-092024-102024-112024-122025-012025-022025-032025-042025-052025-062025-072025-08051015202530
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 31.8 %FULLTEXT: 31.8 %META: 65.7 %META: 65.7 %PDF: 2.6 %PDF: 2.6 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 6.5 %其他: 6.5 %Brazil: 0.9 %Brazil: 0.9 %China: 46.5 %China: 46.5 %Ecuador: 0.7 %Ecuador: 0.7 %Egypt: 0.7 %Egypt: 0.7 %Germany: 2.3 %Germany: 2.3 %India: 2.1 %India: 2.1 %Indonesia: 4.2 %Indonesia: 4.2 %Japan: 0.7 %Japan: 0.7 %Malaysia: 0.7 %Malaysia: 0.7 %Other: 1.4 %Other: 1.4 %Paraguay: 0.7 %Paraguay: 0.7 %Reserved: 0.2 %Reserved: 0.2 %Singapore: 0.2 %Singapore: 0.2 %South Africa: 0.9 %South Africa: 0.9 %Syrian Arab Republic: 0.7 %Syrian Arab Republic: 0.7 %Taiwan, China: 0.9 %Taiwan, China: 0.9 %Turkey: 0.5 %Turkey: 0.5 %United States: 29.0 %United States: 29.0 %其他BrazilChinaEcuadorEgyptGermanyIndiaIndonesiaJapanMalaysiaOtherParaguayReservedSingaporeSouth AfricaSyrian Arab RepublicTaiwan, ChinaTurkeyUnited States

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (280) PDF downloads(11) Cited by(19)
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return