Volume 4 Issue 2
Apr.  2014
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José F. Ovalles, Máximo Gallignani, María R. Brunetto, Rebeca A. Rondón, Carlos Ayala. Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system[J]. Journal of Pharmaceutical Analysis, 2014, (2): 125-131.
Citation: José F. Ovalles, Máximo Gallignani, María R. Brunetto, Rebeca A. Rondón, Carlos Ayala. Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system[J]. Journal of Pharmaceutical Analysis, 2014, (2): 125-131.

Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system

Funds:

The authors are also thankful to the National Fund for Science, Technology and Innovation

Venezuelan Ministry of Science and Technology for providing financial support

  • Publish Date: Apr. 10, 2014
  • The quantitative estimation of amikacin (AMK) in AMK sulfate injection samples is reported using FTIR-derivative spectrometric method in a continuous flow system. Fourier transform of mid-IR spectra were recorded without any sample pretreatment. A good linear calibration (r40.999, %RSDo 2.0) in the range of 7.7-77.0 mg/mL was found. The results showed a good correlation with the manufacturer's and overall they all fell within acceptable limits of most pharmacopoeial monographs on AMK sulfate.
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