Volume 4 Issue 2
Apr.  2014
Turn off MathJax
Article Contents
Hala H. Eldaroti, Suad A. Gadir, Moamen S. Refat, Abdel Majid A. Adam. Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ:Spectroscopic characterization and biological activity studies towards understanding the drug-receptor mechanism[J]. Journal of Pharmaceutical Analysis, 2014, (2): 81-95.
Citation: Hala H. Eldaroti, Suad A. Gadir, Moamen S. Refat, Abdel Majid A. Adam. Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ:Spectroscopic characterization and biological activity studies towards understanding the drug-receptor mechanism[J]. Journal of Pharmaceutical Analysis, 2014, (2): 81-95.

Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ:Spectroscopic characterization and biological activity studies towards understanding the drug-receptor mechanism

  • Publish Date: Apr. 10, 2014
  • Investigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drug-receptor binding mechanism. Structural, thermal, morpholo-gical and biological behavior of CT complexes formed between drug quinidine (Qui) as a donor and quinol (QL), picric acid (PA) or dichlorodicyanobenzoquinone (DDQ) as acceptors were reported. The newly synthesized CT complexes have been spectroscopically characterized via elemental analysis;infrared (IR), Raman, 1H NMR and electronic absorption spectroscopy; powder X-ray diffraction (PXRD);thermogravimetric (TG) analysis and scanning electron microscopy (SEM). It was found that the obtained complexes are nanoscale, semi-crystalline particles, thermally stable and spontaneous. The molecular composition of the obtained complexes was determined using spectrophotometric titration method and was found to be 1:1 ratios (donor:acceptor). Finally, the biological activities of the obtained CT complexes were tested for their antibacterial activities. The results obtained herein are satisfactory for estimation of drug Qui in the pharmaceutical form.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (86) PDF downloads(0) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return