BER-Ago: A simultaneous detection and inhibitor screening platform for multiple base excision repair proteins

Sheng Ding; Ju Chen; Jing Li; Ting Zhu; Wenyue Jia; Shiqi Xiao; Jin Yang; Dianxiang Lu

doi:10.1016/j.jpha.2025.101507

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Sheng Ding, Ju Chen, Jing Li, Ting Zhu, Wenyue Jia, Shiqi Xiao, Jin Yang, Dianxiang Lu. BER-Ago: A simultaneous detection and inhibitor screening platform for multiple base excision repair proteins[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101507

Citation:

Sheng Ding, Ju Chen, Jing Li, Ting Zhu, Wenyue Jia, Shiqi Xiao, Jin Yang, Dianxiang Lu. BER-Ago: A simultaneous detection and inhibitor screening platform for multiple base excision repair proteins[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101507

Citation:

Sheng Ding, Ju Chen, Jing Li, Ting Zhu, Wenyue Jia, Shiqi Xiao, Jin Yang, Dianxiang Lu. BER-Ago: A simultaneous detection and inhibitor screening platform for multiple base excision repair proteins[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101507

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BER-Ago: A simultaneous detection and inhibitor screening platform for multiple base excision repair proteins

doi: 10.1016/j.jpha.2025.101507

Sheng Ding^a,b,
Ju Chen^a,b,
Jing Li^a,
Ting Zhu^a,
Wenyue Jia^a,
Shiqi Xiao^a,b,
Jin Yang^{a,b
,
,},
Dianxiang Lu^{a,b
,
,}

a. Clinical Medical College & Affiliated Hospital, Chengdu University, Chengdu, 610106, China;
b. Laboratory of Extreme Environment Medical Engineering and Applied Innovation, Chengdu University, Chengdu, 610106, China

Funds:

This work was supported by Sichuan Science and Technology Program (Grant No.: 2024YFFK0280), the National Natural Science Foundation of China (Grant Nos.: 82402725 and 82374148), Tibet Autonomous Region Science and Technology Program Key R&

D and Transformation Project Plateau Intelligent Oxygen Supply Model Construction and Application Research, Science and Technology Innovation Team Project of Research on Diagnosis and Treatment of Diseases in the Low Oxygen Environment of Plateau and Data Application and Analysis in Chengdu University, Key Research Project of Clinical Medical College &

Affiliated Hospital of Chengdu University (Grant No.: Y202403), and 2024 Undergraduate Innovation Training Program Incubation and Cultivation Project (Grant No.: S202411079085).

Received Date: Sep. 04, 2025
Accepted Date: Dec. 01, 2025
Rev Recd Date: Nov. 30, 2025
Available Online: Dec. 04, 2025

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References(5)

References

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[2]	L. Wang, H. Zhang, W. Chen, et al., Recent advances in DNA glycosylase assays, Chin. Chem. Lett. 33 (2022) 3603-3612.
[3]	H. Li, F. Zheng, Z. Yang, et al., Trends in the use of argonaute proteins in molecular diagnosis, Trac Trends Anal. Chem. 183 (2025), 118081.
[4]	C. Li, H. Chen, J. Hu, et al., Rolling circle amplification-driven encoding of different fluorescent molecules for simultaneous detection of multiple DNA repair enzymes at the single-molecule level, Chem. Sci. 11 (2020) 5724-5734.
[5]	X. Li, R. Singh, B. Zhang, et al., Ultralow-limit of detection optical fiber LSPR biosensor based on a ring laser for des-γ-carboxy prothrombin detection, Photon. Res. 13 (2025) 698-708.