High-Throughput Screening of EGFR/Ca²⁺ Signaling Modulators in Cardiac Hypertrophy Using a Tetrahedral DNA Nanostructure-Based hESC Platform

doi: 10.1016/j.jpha.2025.101479

• Ke-Jia Wu^1,2 , 
• Yan-Fa Dai¹ , 
• Zhi-Qiang Wang³ , 
• Wen Sun⁴ , 
• Ya-Nan Zhu¹ , 
• Fan Chen¹ , 
• Ling Shao¹ , 
• Yao-Ye Huang¹ , 
• Qi Chen^1,2 , 
• Xin Liu⁵ , 
• Yan Li^{4 ,  ,}  , 
• Hui-Min David Wang^6,7,8,9 , 
• Ning Sun^{1,2 ,  ,} 

• 1 Wuxi School of Medicine, Affiliated Hospital of Jiangnan University, Jiangnan University, Wuxi, Jiangsu, 214122, China;

• 2 MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, Ministry of Education, Jiangnan University, Wuxi, Jiangsu, 214122, China;

• 3 Department of Cardiothoracic Surgery, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214122, China;

• 4 Key Laboratory of Animal Biological Products & Genetic Engineering, Ministry of Agriculture and Rural, Sinopharm Animal Health Corporation Ltd., Wuhan, 100125, China;

• 5 College of Food Science and Engineering, Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan Polytechnic University, Wuhan, 430023, China;

• 6 Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan, 402202, China;

• 7 Regenerative Medicine and Cell Therapy Research Center;

• and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, 80708, China;

• 8 Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan, 40402, China;

• 9 Center of Applied Nanomedicine, National Cheng Kung University, Tainan, Taiwan, 70101, China