Targeting angiogenesis in diabetic wound healing: New insight from chemical architecture to functional outcomes

Junren Chen; Siqi Qin; Ziwei Xing; Cheng Peng; Dan Li

doi:10.1016/j.jpha.2025.101475

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Junren Chen, Siqi Qin, Ziwei Xing, Cheng Peng, Dan Li. Targeting angiogenesis in diabetic wound healing: New insight from chemical architecture to functional outcomes[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101475

Citation:

Junren Chen, Siqi Qin, Ziwei Xing, Cheng Peng, Dan Li. Targeting angiogenesis in diabetic wound healing: New insight from chemical architecture to functional outcomes[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101475

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Targeting angiogenesis in diabetic wound healing: New insight from chemical architecture to functional outcomes

doi: 10.1016/j.jpha.2025.101475

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China

Funds:

The work was supported by the National Natural Science Foundation of China (Grant Nos.: U24A20790 and 82104477), Sichuan Science and Technology Program, China (Grant No.: 2024NSFSC0054), Sichuan Traditional Chinese Medicine Technology Industry Innovation Team, China (Grant No.: 2022C001), Science and Technology Research Project of Sichuan Administration of Traditional Chinese Medicine, China (Grant No.: 2024ZD02), and Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine, China (Grant No.: ZYYCXTD-D-202209). Figs. 1, 3, 5, 6, and Graphical abstract were drawn by using BioRender.com (https://app.biorender.com).

Received Date: Jun. 30, 2025
Accepted Date: Oct. 23, 2025
Rev Recd Date: Oct. 18, 2025
Available Online: Oct. 25, 2025

Abstract

Abstract

Diabetic wound healing (DWH) is a multifaceted process hindered by impaired angiogenesis that usually leads to increased risks of infection and amputation. Targeting impeded angiogenic signals to restore the microenvironment favoring vascular network re-establishment is a promising therapeutic strategy for diabetic wound. Natural products have emerged as potential therapeutic agents for diabetic wounds by regulating endotheliocytes functions and their cross-talks with immune cells and fibroblasts, while the similarities and differences of the chemical structures greatly determine their distinct efficient and underlying mechanisms in diabetic wound angiogenesis. In this review, relevant literature was retrieved from PubMed, Google Scholar, and Web of Science databases, covering publications from 2020 to 2025. This paper reviews the role of angiogenesis in DWH and the action of natural products in DWH by targeting angiogenesis, particularly highlighting their chemical architecture driven specific biological activity on angiogenesis, with the aim of providing references for angiogenesis-based therapeutic strategies for diabetic ulcers and promoting the development of angiogenesis-targeting agents.
- Diabetic wound healing,
- Angiogenesis,
- Natural products,
- Structure-activity relationships,
- Endothelial cells

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References(133)

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