The correlation between characteristics and pharmacological effects of Monoterpene glycosides and Tannins in Radix Paeoniae Alba

Qitong Zheng; Mengyao Chen; Jialiang Ying; Zhichao Wang; Qiyuan Shan; Xia-Nan Sang; Gang Cao

doi:10.1016/j.jpha.2025.101471

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Qitong Zheng, Mengyao Chen, Jialiang Ying, Zhichao Wang, Qiyuan Shan, Xia-Nan Sang, Gang Cao. The correlation between characteristics and pharmacological effects of Monoterpene glycosides and Tannins in Radix Paeoniae Alba[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101471

Citation:

Qitong Zheng, Mengyao Chen, Jialiang Ying, Zhichao Wang, Qiyuan Shan, Xia-Nan Sang, Gang Cao. The correlation between characteristics and pharmacological effects of Monoterpene glycosides and Tannins in Radix Paeoniae Alba[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101471

Citation:

Qitong Zheng, Mengyao Chen, Jialiang Ying, Zhichao Wang, Qiyuan Shan, Xia-Nan Sang, Gang Cao. The correlation between characteristics and pharmacological effects of Monoterpene glycosides and Tannins in Radix Paeoniae Alba[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101471

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The correlation between characteristics and pharmacological effects of Monoterpene glycosides and Tannins in Radix Paeoniae Alba

doi: 10.1016/j.jpha.2025.101471

School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, 310053, China

Funds:

This work was supported by the National Natural Science Foundation of China (Grant Nos.: 82274101 and 82374123), the Natural Science Foundation of Zhejiang Province, China (Grant No.: LY24H280002), and the Research Project of Zhejiang Chinese Medical University (Grant No.: 2025JKZKTS23). Figs. 1−10 and the Graphical abstract were created using BioRender.com.

Received Date: Apr. 30, 2025
Accepted Date: Oct. 19, 2025
Rev Recd Date: Oct. 17, 2025
Available Online: Oct. 25, 2025

Abstract

Abstract

The pharmacodynamic material basis constitutes the central element of traditional Chinese medicine (TCM) in disease treatment. By summarizing the active compounds' characteristics, bioavailability, pharmacological effects, and molecular mechanisms, we can explain the complex interactions between TCMs and diseases. Previous studies have demonstrated that monoterpene glycosides and tannins are related to the pharmacological activity of Radix Paeoniae Alba (RPA). However, research on RPA has primarily focused on monoterpene glycosides, and the functional role of tannins in RPA has received little attention. Observations from animal studies indicate that monoterpene glycosides and tannins exhibit poor bioavailability. Carboxylesterase, produced by gut microbiota, is crucial for metabolizing these compounds in the intestine. Monoterpene glycosides and their gut metabolites can be absorbed into the bloodstream, exerting various pharmacological effects, including anti-inflammatory, immunomodulatory, and neuromodulator activities. In contrast, tannins consist of highly hydrophobic polyphenols that form insoluble protein-tannin complexes. Due to their inability to cross the intestinal barrier, tannins primarily exert localized pharmacological effects within the digestive system. This study systematically reviews the pharmacological activities and mechanisms of monoterpene glycosides and tannins in RPA, while establishing their therapeutic contributions to the herb's pharmacological effects.
- Material basis,
- Radix Paeoniae Alba,
- Monoterpene glycosides,
- Tannins,
- Pharmacological action

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References(147)

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