Real-Time Visualization of Drug-Target Interactions in Native Subcellular Microenvironments for Lysosome-targeted Drug Discovery

doi: 10.1016/j.jpha.2025.101428

• Ran Wang^a,b,c , 
• Yatong Yuan^c , 
• Huarong Shao^d , 
• Yuehao Sun^e , 
• Changcheng Lai^f , 
• Mengrui Zhang^c , 
• Wenjing Song^b , 
• Tao Zhang^g , 
• Fengfeng Zhuang^{h ,  ,}  , 
• Qixin Chenⁱ , 
• Peixue Ling^{a ,  ,}  , 
• Xintian Shao^{b ,  ,} 

• a National Glycoengineering Research Center, Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, Shandong, 266237, China;

• b School of Life Sciences, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China;

• c School of Pharmaceutical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250101, China;

• d Shandong Academy of Pharmaceutical Sciences, Engineering Research Center for Sugar and Sugar Complex, National-Local Joint Engineering Laboratory of Polysaccharide Drugs, Key Laboratory of Carbohydrate and Glycoconjugate Drugs, Jinan, 250101, China;

• e College of Clinical and Basic Medicine (Institute of Basic Medicine), Shandong First Medical University, Jinan, 250101, China;

• f Zunyi Medical University, Zunyi, Guizhou, 563006, China;

• g Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250014, China;

• h School of Health Industry Management & School of Medicine & Health Sciences, University of Sanya, Sanya, Hainan, 572022, China;

• i Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, 119074, Singapore