Mengjia Xu, Lutfun Nahar, Kenneth J. Ritchie, Chenxu Wang, Li Cheng, Zimiao Wu, Satyajit D. Sarker, Mingquan Guo. Recent advances in nanomaterial-based optical biosensors and their biomedical and biopharmaceutical applications[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101349
Citation:
Mengjia Xu, Lutfun Nahar, Kenneth J. Ritchie, Chenxu Wang, Li Cheng, Zimiao Wu, Satyajit D. Sarker, Mingquan Guo. Recent advances in nanomaterial-based optical biosensors and their biomedical and biopharmaceutical applications[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101349
Mengjia Xu, Lutfun Nahar, Kenneth J. Ritchie, Chenxu Wang, Li Cheng, Zimiao Wu, Satyajit D. Sarker, Mingquan Guo. Recent advances in nanomaterial-based optical biosensors and their biomedical and biopharmaceutical applications[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101349
Citation:
Mengjia Xu, Lutfun Nahar, Kenneth J. Ritchie, Chenxu Wang, Li Cheng, Zimiao Wu, Satyajit D. Sarker, Mingquan Guo. Recent advances in nanomaterial-based optical biosensors and their biomedical and biopharmaceutical applications[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2025.101349
1 Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Ningbo Cixi Institute of Biomedical Engineering, Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201, China;
2 College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China;
3 Laboratory of Growth Regulators, Palacký University and Institute of Experimental Botany, The Czech Academy of Sciences, Olomouc, 78371, Czech Republic;
4 Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK;
5 Affiliated Cixi Hospital, Wenzhou Medical University, Ningbo, Zhejiang, 315300, China
Optical biosensors are gaining popularity owing to their portability, miniaturization, no requirement for additional attachments and rapid responsiveness. These features render them suitable for various applications including at-home diagnostics, pharmacology, and continuous molecular monitoring. The integration of functionalized lowdimensional nanomaterials (zero-dimensional (0D), 1D, 2D, and 3D) has redirected focus towards the design, fabrication and optimization of optical biosensors. This review summarizes the fundamental mechanisms underlying optical biosensing. The key mechanisms include localized surface plasmon resonance (LSPR), photoluminescence (PL), surface enhancement Raman scattering (SERS), nanozymebased colorimetric strategies, chemiluminescence, bioluminescence and electrochemiluminescence. The advantages of various low-dimensional nanomaterials for different types of optical biosensors are presented. This comparison emphasizes their potential superiority in targeted biosensing applications. Therefore, promoting optical biosensing techniques and recent developments in advanced biosensing strategies for biomedical research and biopharmaceutical applications is necessary to establish their future directions.