Greenness evaluation metric for analytical methods and software

Tong Xin; Luyao Yu; Wenying Zhang; Yingxia Guo; Chuya Wang; Zhong Li; Jiansong You; Hongyu Xue; Meiyun Shi; Lei Yin

doi:10.1016/j.jpha.2025.101202

Volume 15 Issue 7

Jul. 2025

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Tong Xin, Luyao Yu, Wenying Zhang, Yingxia Guo, Chuya Wang, Zhong Li, Jiansong You, Hongyu Xue, Meiyun Shi, Lei Yin. Greenness evaluation metric for analytical methods and software[J]. Journal of Pharmaceutical Analysis, 2025, 15(7): 101202. doi: 10.1016/j.jpha.2025.101202

Citation:

Tong Xin, Luyao Yu, Wenying Zhang, Yingxia Guo, Chuya Wang, Zhong Li, Jiansong You, Hongyu Xue, Meiyun Shi, Lei Yin. Greenness evaluation metric for analytical methods and software[J]. Journal of Pharmaceutical Analysis, 2025, 15(7): 101202. doi: 10.1016/j.jpha.2025.101202

Citation:

Tong Xin, Luyao Yu, Wenying Zhang, Yingxia Guo, Chuya Wang, Zhong Li, Jiansong You, Hongyu Xue, Meiyun Shi, Lei Yin. Greenness evaluation metric for analytical methods and software[J]. Journal of Pharmaceutical Analysis, 2025, 15(7): 101202. doi: 10.1016/j.jpha.2025.101202

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Greenness evaluation metric for analytical methods and software

doi: 10.1016/j.jpha.2025.101202

Tong Xin^a,
Luyao Yu^a,
Wenying Zhang^a,
Yingxia Guo^a,
Chuya Wang^a,
Zhong Li^b,
Jiansong You^c,
Hongyu Xue^{a
,
,},
Meiyun Shi^{a,c
,
,},
Lei Yin^{a
,
,}

a. School of Chemical Engineering, Ocean and Life Sciences, Dalian University of Technology, Panjin, Liaoning, 124221, China;
b. Dalian Women & Children’s Medical Group, Pharmaceutical Department, Dalian, Liaoning, 116012, China;
c. Aim Honesty Biopharmaceutical Co., Ltd., Dalian, Liaoning, 116600, China

Funds:

This work was financially supported by the National Natural Science Foundation of China (Grant Nos.: 81603182 and 81703607), the Fundamental Research Funds for the Central Universities, China (Grant Nos.: DUT21RC(3)057, DUT23YG226, DUT24MS018, and DUT23YG228), the Natural Science Foundation of Liaoning Province, China (Grant No.: 2023-MSBA-018), and the Open Funding of Cancer Hospital of Dalian University of Technology, China (Grant No.: 2024-ZLKF-33). We thank LetPub (www.letpub.com.cn) for its linguistic assistance during the preparation of this manuscript.

Received Date: Aug. 01, 2024
Accepted Date: Jan. 16, 2025
Rev Recd Date: Dec. 16, 2024
Publish Date: Jan. 23, 2025

Abstract

Abstract

The focus of green analytical chemistry (GAC) is to minimize the negative impacts of analytical procedures on human safety, human health, and the environment. Several factors, such as the reagents used, sample collection, sample processing, instruments, energy consumed, and the quantities of hazardous materials and waste generated during analytical procedures, need to be considered in the evaluation of the greenness of analytical assays. In this study, we propose a greenness evaluation metric for analytical methods (GEMAM). The new greenness metric is simple, flexible, and comprehensive. The evaluation criteria are based on both the 12 principles of GAC (SIGNIFICANCE) and the 10 factors of sample preparation, and the results are presented on a 0–10 scale. The GEMAM calculation process is easy to perform, and its results are easy to interpret. The output of GEMAM is a pictogram that can provide both qualitative and quantitative information based on color and number.
- Green analytical chemistry,
- Analytical methods,
- Greenness evaluation,
- Metric

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References(46)

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