Volume 15 Issue 7
Jul.  2025
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Qingxia Huang, Qinsheng Chen, Xiaoxuan Yi, Huan Wang, Qi Wang, Haijuan Zhi, Junfang Wu, Dao Wen Wang, Huiru Tang. Reproducibility of the NMR-based quantitative metabolomics and HBV-caused changes in human serum lipoprotein subclasses and small metabolites[J]. Journal of Pharmaceutical Analysis, 2025, 15(7): 101180. doi: 10.1016/j.jpha.2024.101180
Citation: Qingxia Huang, Qinsheng Chen, Xiaoxuan Yi, Huan Wang, Qi Wang, Haijuan Zhi, Junfang Wu, Dao Wen Wang, Huiru Tang. Reproducibility of the NMR-based quantitative metabolomics and HBV-caused changes in human serum lipoprotein subclasses and small metabolites[J]. Journal of Pharmaceutical Analysis, 2025, 15(7): 101180. doi: 10.1016/j.jpha.2024.101180

Reproducibility of the NMR-based quantitative metabolomics and HBV-caused changes in human serum lipoprotein subclasses and small metabolites

doi: 10.1016/j.jpha.2024.101180
Funds:

We acknowledge financial supports from the National Key R&

D Program of China (Grant Nos.: 2022YFC3400700 and 2022YFA0806400), the Shanghai Municipal Science and Technology Major Project, China (Grant No.: 2017SHZDZX01), and the National Natural Science Foundation of China (Grant No.: 31821002).

  • Received Date: May 12, 2024
  • Accepted Date: Dec. 29, 2024
  • Rev Recd Date: Dec. 24, 2024
  • Available Online: Aug. 15, 2025
  • Publish Date: Dec. 31, 2024
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    B. Jimenez, E. Holmes, C. Heude, et al., Quantitative lipoprotein subclass and low molecular weight metabolite analysis in human serum and plasma by 1H NMR spectroscopy in a multilaboratory trial, Anal. Chem. 90 (2018) 11962-11971.
    [4]
    J. Pinto, E. Galhano, et al., Human plasma stability during handling and storage: Impact on NMR metabolomics, Analyst 139 (2014) 1168-1177.
    [5]
    D. Zuo, H. An, J. Li, et al., The application value of lipoprotein particle numbers in the diagnosis of HBV-related hepatocellular carcinoma with BCLC stage 0-A, J. Pers. Med. 11 (2021) 1143.
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