Discovery of E0199: A novel compound targeting both peripheral Na_V and K_V7 channels to alleviate neuropathic pain

doi: 10.1016/j.jpha.2024.101132

• Boxuan Zhang^a , 
• Xiaoxing Shi^b , 
• Xingang Liu^a , 
• Yan Liu^c , 
• Xuedong Li^a , 
• Qi Wang^d , 
• Dongyang Huang^b , 
• Weidong Zhao^b , 
• Junru Cui^e , 
• Yawen Cao^b , 
• Xu Chai^b , 
• Jiahao Wang^b , 
• Yang Zhang^{a ,  ,}  , 
• Xiangyu Wang^{f,g ,  ,}  , 
• Qingzhong Jia^{a ,  ,} 

• a Department of Pharmaceutical Chemistry, College of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, China;

• b Department of Pharmacology, College of Basic Medical, Hebei Medical University, Shijiazhuang, 050017, China;

• c Department of Pharmaceutical Experimental Teaching Center, College of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, China;

• d Shijiazhuang Xianyu Digital Biotechnology Co., Ltd., College of Software, Hebei Normal University, Shijiazhuang, 050024, China;

• e The Center for New Drug Safety Evaluation and Research, Hebei Medical University, Shijiazhuang, 050017, China;

• f Hebei Medical University Postdoctoral Mobile Station of Basic Medical, Hebei Medical University, Shijiazhuang 050017, China;

• g Departments of Clinic Pharmacy, College of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, China