Integrating transcriptomics, metabolomics, and network pharmacology to investigate multi-target effects of Sporoderm-broken spores of Ganoderma lucidum on improving HFD-induced diabetic nephropathy rats

doi: 10.1016/j.jpha.2024.101105

• Lidan Hu^a , 
• Lili Yu^b,c , 
• Zhongkai Cao^a , 
• Yue Wang^d , 
• Caifeng Zhu^e , 
• Yayu Li^e , 
• Jiazhen Yin^e , 
• Zhichao Ma^a , 
• Xuelin He^f , 
• Ying Zhang^g , 
• Wunan Huang^a , 
• Yuelin Guan^a , 
• Yue Chen^{h ,  ,}  , 
• Xue Li^{c ,  ,}  , 
• Xiangjun Chen^{g ,  ,} 

• a Department of Nephrology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310003, Zhejiang, China;

• b Centre for Global Health, Usher Institute, The University of Edinburgh, 5-7 Little France Road, Edinburgh, EH16 4UX, UK;

• c Department of Big Data in Health Science School of Public Health, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China;

• d Hubei Normal University. No. 11, Cihu Road, Huangshi, 435002, Hubei, China;

• e Department of Nephrology, Hangzhou TCM Hospital, Hangzhou, 310007, Zhejiang, China;

• f Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang, China g Institute of Translational Medicine, Zhejiang University School of Medicine, 268 Kaixuan Road, Hangzhou, 310020, Zhejiang, China. h Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin, 300211, China