Blocking the adverse outcome pathway of skin sensitization through a N-acetyl cysteine and lysine-loaded hydrogel

doi: 10.1016/j.jpha.2024.101071

• Gonçalo S. Brites^a,b,c,d , 
• Isabel Ferreira^a,c,d , 
• Ana I. Sebastião^a , 
• Cátia Sousa^a,c,d , 
• Ana Silva^c,d , 
• Mylene Carrascal^c,d , 
• Rui C. Oliveira^e , 
• Margarida Gonçalo^f , 
• Carla Vitorino^a,g , 
• Bruno M. Neves^{b,h ,  ,}  , 
• Maria T. Cruz^{a,b,c ,  ,} 

• a Faculty of Pharmacy, University of Coimbra, 3000-548, Coimbra, Portugal;

• b Toxfinder, Lda, IPN - Instituto Pedro Nunes, 3030-199, Coimbra, Portugal;

• c Center for Neuroscience and Cell Biology - CNC, University of Coimbra, 3004-504, Coimbra, Portugal;

• d Center for Innovative Biomedicine and Biotechnology - CIBB, University of Coimbra, 3004-548, Coimbra; Portugal;

• e Pathology Department, Coimbra Hospital and University Center, 3000-075, Coimbra, Portugal;

• f Dermatology Department, Coimbra Hospital and University Center, 3000-075, Coimbra, Portugal;

• g Coimbra Chemistry Center, Department of Chemistry, University of Coimbra, 3004- 535 Coimbra, Portugal;

• h Department of Medical Sciences and Institute of Biomedicine – iBiMED, University of Aveiro, 3810-193, Aveiro, Portugal