Ursodeoxycholic acid inhibits the uptake of cystine through SLC7A11 and impairs de novo synthesis of glutathione

doi: 10.1016/j.jpha.2024.101068

• Fu'an Xie^a , 
• Yujia Niu^b , 
• Xiaobing Chen^c , 
• Xu Kong^a , 
• Guangting Yan^a , 
• Aobo Zhuang^a , 
• Xi Li^d , 
• Lanlan Lian^e , 
• Dongmei Qin^a , 
• Quan Zhang^f , 
• Ruyi Zhang^a , 
• Kunrong Yang^g , 
• Xiaogang Xia^h , 
• Kun Chen^h , 
• Mengmeng Xiaoⁱ , 
• Chunkang Yang^j , 
• Ting Wu^a , 
• Ye Shen^{c ,}  , 
• Chundong Yu^{k ,}  , 
• Chenghua Luo^{b ,}  , 
• Shu-Hai Lin^{i ,}  , 
• Wengang Li^{b ,} 

• a Cancer Research Center, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, P. R. China;

• b State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361102, P. R. China;

• c Department of Retroperitoneal Tumor Surgery, Peking University International Hospital, Beijing, 102206, P. R. China;

• d School of Public Health, Harvard University, Boston, MA, USA;

• e Department of Laboratory Medicine, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, Fujian 361102, P. R. China;

• f National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, Fujian 361102, P. R. China;

• g Laboratory of Biochemistry and Molecular Biology Research, Department of Clinical Laboratory, Fujian Medical University Cancer Hospital, Fujian 350014, P. R. China;

• h Department of Hepatobiliary Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, P. R. China;

• i Department of General Surgery, Peking University People's Hospital, Beijing, 100032, P. R. China;

• j Department of Gastrointestinal Surgical Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fujian 350014, P. R. China;

• k Department of Management, Jiang Xia Blood Technology Co., Ltd., Shanghai 200000, P. R. China