Determination of related substances in disulfide-rich peptide ziconotide by establishing tandem mass spectrometry methods

Yuya Cheng; Peize Wu; Peng Xiao; Ming Li

doi:10.1016/j.jpha.2024.101037

Volume 14 Issue 10

Oct. 2024

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Yuya Cheng, Peize Wu, Peng Xiao, Ming Li. Determination of related substances in disulfide-rich peptide ziconotide by establishing tandem mass spectrometry methods[J]. Journal of Pharmaceutical Analysis, 2024, 14(10): 101037. doi: 10.1016/j.jpha.2024.101037

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Yuya Cheng, Peize Wu, Peng Xiao, Ming Li. Determination of related substances in disulfide-rich peptide ziconotide by establishing tandem mass spectrometry methods[J]. Journal of Pharmaceutical Analysis, 2024, 14(10): 101037. doi: 10.1016/j.jpha.2024.101037

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Determination of related substances in disulfide-rich peptide ziconotide by establishing tandem mass spectrometry methods

doi: 10.1016/j.jpha.2024.101037

Division of Chemical Metrology & Analytical Science, National Institute of Metrology, Beijing, 100029, China

Funds:

The authors thank the funding from the National Key R&D Program of China (Grant No.:2021YFF0600704 and 2021YFF0600701).

Received Date: Oct. 07, 2023
Accepted Date: Jul. 01, 2024
Rev Recd Date: Jun. 27, 2024
Publish Date: Jul. 02, 2024

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References(5)

References

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[3]	L.C. Wu, F. Chen, S.L. Lee, et al., Building parity between brand and generic peptide products: regulatory and scientific considerations for quality of synthetic peptides, Int. J. Pharm. 518 (2017) 320-334.
[4]	P. Bros, R.D. Josephs, N. Stoppacher, et al., Impurity determination for hepcidin by liquid chromatography-high resolution and ion mobility mass spectrometry for the value assignment of candidate primary calibrators, Anal. Bioanal. Chem. 409 (2017) 2559-2567.
[5]	M. Gongora-Benitez, J. Tulla-Puche, F. Albericio, Multifaceted roles of disulfide bonds. Peptides as therapeutics, Chem. Rev. 114 (2014) 901-926.