An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy

Xinyang Zhu; Chao He; Longfei Tan; Xun Qi; Meng Niu; Xianwei Meng; Hongshan Zhong

doi:10.1016/j.jpha.2024.02.006

Volume 14 Issue 7

Jul. 2024

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Xinyang Zhu, Chao He, Longfei Tan, Xun Qi, Meng Niu, Xianwei Meng, Hongshan Zhong. An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy[J]. Journal of Pharmaceutical Analysis, 2024, 14(7): 100952. doi: 10.1016/j.jpha.2024.02.006

Citation:

Xinyang Zhu, Chao He, Longfei Tan, Xun Qi, Meng Niu, Xianwei Meng, Hongshan Zhong. An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy[J]. Journal of Pharmaceutical Analysis, 2024, 14(7): 100952. doi: 10.1016/j.jpha.2024.02.006

Citation:

Xinyang Zhu, Chao He, Longfei Tan, Xun Qi, Meng Niu, Xianwei Meng, Hongshan Zhong. An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy[J]. Journal of Pharmaceutical Analysis, 2024, 14(7): 100952. doi: 10.1016/j.jpha.2024.02.006

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An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy

doi: 10.1016/j.jpha.2024.02.006

a. Department of Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China;
b. Xixian New Area Rimag Medical Diagnosis Center, Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712099, China;
c. Laboratory of Controllable Preparation and Application of Nanomaterials, Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China

Funds:

This work was supported by the National Key R&D Program of China (Grant No.: 2018YFC0115500), the National Natural Science Foundation of China (Grant No.: U21A20378), Liaoning Revitalization Talents Program, China (Grant No.: XLYC1802098), the Natural Science Foundation of Shaanxi Provincical Department of Education, China (Grant No.: 21JK0593), and the Key Research and Development Plan of Science and Technology Department of Xianyang City, China (Grant No.: L2023-ZDYF-SF-054).

Received Date: Sep. 15, 2023
Accepted Date: Feb. 19, 2024
Rev Recd Date: Jan. 18, 2024
Publish Date: Feb. 27, 2024

Abstract

Abstract

Microwave thermotherapy (MWTT), as a treatment for tumors, lacks specificity and requires sensitizers. Most reported microwave sensitizers are single metal-organic frameworks (MOFs), which must be loaded with ionic liquids to enhance the performance in MWTT. Meanwhile, MWTT is rarely combined with other treatment modalities. Here, we synthesized a novel Fe-Cu bimetallic organic framework FeCuMOF (FCM) by applying a hydrothermal method and further modified it with methyl polyethylene glycol (mPEG). The obtained FCM@PEG (FCMP) showed remarkable heating performance under low-power microwave irradiation; it also acted as a novel nanospheres enzyme to catalyze H₂O₂ decomposition, producing abundant reactive oxygen species (ROS) to deplete glutathione (GSH) and prevent ROS clearance from tumor cells during chemodynamic treatment. The FCMP was biodegradable and demonstrated excellent biocompatibility, allowing it to be readily metabolized without causing toxic effects. Finally, it was shown to act as a suitable agent for T₂ magnetic resonance imaging (MRI) in vitro and in vivo. This new bimetallic nanostructure could successfully realize two tumor treatment modalities (MWTT and chemodynamic therapy) and dual imaging modes (T₂ MRI and microwave thermal imaging). Our findings represent a breakthrough for integrating the diagnosis and treatment of tumors and provides a reference for developing new microwave sensitizers.
- Microwave thermotherapy,
- Metal organic frameworks,
- Glutathione scavenging,
- Magnetic resonance imaging,
- Synergism

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References(30)

References

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