Volume 14 Issue 7
Jul.  2024
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Article Navigation >  Journal of Pharmaceutical Analysis  > 2024  >  14(7): 100947
Xuejiao Leng, Mengyuan Zhang, Yujing Xu, Jingjing Wang, Ning Ding, Yancheng Yu, Shanliang Sun, Weichen Dai, Xin Xue, Nianguang Li, Ye Yang, Zhihao Shi. Non-coding RNAs as therapeutic targets in cancer and its clinical application[J]. Journal of Pharmaceutical Analysis, 2024, 14(7): 100947. doi: 10.1016/j.jpha.2024.02.001
Citation: Xuejiao Leng, Mengyuan Zhang, Yujing Xu, Jingjing Wang, Ning Ding, Yancheng Yu, Shanliang Sun, Weichen Dai, Xin Xue, Nianguang Li, Ye Yang, Zhihao Shi. Non-coding RNAs as therapeutic targets in cancer and its clinical application[J]. Journal of Pharmaceutical Analysis, 2024, 14(7): 100947. doi: 10.1016/j.jpha.2024.02.001
shu

Non-coding RNAs as therapeutic targets in cancer and its clinical application

doi: 10.1016/j.jpha.2024.02.001

  • a. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China;

  • b. School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China;

  • c. Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University, Nanjing, 211198, China

Funds:

This work was financially supported by the National Natural Science Foundation of China (Grant Nos.: 81973171, 82103985, and 82373710), the National Key Research and Development Program of China (Grant No.: 2020YFA0509404), the Natural Science Foundation of Jiangsu Provincial Colleges and Universities (Grant No.: 21KJB350005), the Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine (Grant No.: 2020YLXK002), Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

  • Received Date: Oct. 27, 2023
  • Accepted Date: Feb. 01, 2024
  • Rev Recd Date: Jan. 12, 2024
  • Publish Date: Feb. 08, 2024
    Abstract

  • Cancer genomics has led to the discovery of numerous oncogenes and tumor suppressor genes that play critical roles in cancer development and progression. Oncogenes promote cell growth and proliferation, whereas tumor suppressor genes inhibit cell growth and division. The dysregulation of these genes can lead to the development of cancer. Recent studies have focused on non-coding RNAs (ncRNAs), including circular RNA (circRNA), long non-coding RNA (lncRNA), and microRNA (miRNA), as therapeutic targets for cancer. In this article, we discuss the oncogenes and tumor suppressor genes of ncRNAs associated with different types of cancer and their potential as therapeutic targets. Here, we highlight the mechanisms of action of these genes and their clinical applications in cancer treatment. Understanding the molecular mechanisms underlying cancer development and identifying specific therapeutic targets are essential steps towards the development of effective cancer treatments.

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