A novel fluorescent labeling compound for GluN2A containing <i>N</i>-methyl-D-aspartate receptors identified by autodisplay-based screening

Alexander Dombovski; Ruben Steigerwald; Nadine Ritter; Paul Disse; Gunnar Goerges; Jana Osthues; Isabel Aymanns; Carina Dilkaute; Julian Schreiber; Martina Düfer; Guiscard Seebohm; Bernhard Wünsch; Joachim Jose

doi:10.1016/j.jpha.2024.01.013

Volume 14 Issue 7

Jul. 2024

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Alexander Dombovski, Ruben Steigerwald, Nadine Ritter, Paul Disse, Gunnar Goerges, Jana Osthues, Isabel Aymanns, Carina Dilkaute, Julian Schreiber, Martina Düfer, Guiscard Seebohm, Bernhard Wünsch, Joachim Jose. A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by autodisplay-based screening[J]. Journal of Pharmaceutical Analysis, 2024, 14(7): 100945. doi: 10.1016/j.jpha.2024.01.013

Citation:

Alexander Dombovski, Ruben Steigerwald, Nadine Ritter, Paul Disse, Gunnar Goerges, Jana Osthues, Isabel Aymanns, Carina Dilkaute, Julian Schreiber, Martina Düfer, Guiscard Seebohm, Bernhard Wünsch, Joachim Jose. A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by autodisplay-based screening[J]. Journal of Pharmaceutical Analysis, 2024, 14(7): 100945. doi: 10.1016/j.jpha.2024.01.013

Citation:

Alexander Dombovski, Ruben Steigerwald, Nadine Ritter, Paul Disse, Gunnar Goerges, Jana Osthues, Isabel Aymanns, Carina Dilkaute, Julian Schreiber, Martina Düfer, Guiscard Seebohm, Bernhard Wünsch, Joachim Jose. A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by autodisplay-based screening[J]. Journal of Pharmaceutical Analysis, 2024, 14(7): 100945. doi: 10.1016/j.jpha.2024.01.013

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A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by autodisplay-based screening

doi: 10.1016/j.jpha.2024.01.013

a. University of Münster, Institute of Pharmaceutical and Medicinal Chemistry, Pharmacampus, 48149, Münster, Germany;
b. University of Münster, GRK 2515, Chemical Biology of Ion Channels (Chembion), 48149, Münster, Germany;
c. University of Münster, Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, 48149, Münster, Germany

Funds:

This work was supported by the Research Training Group “Chemical biology of ion channels (Chembion)”, funded by the German Research Foundation (DFG), Germany (Project No: 404595355, GRK: 2515).

Received Date: Sep. 28, 2023
Accepted Date: Jan. 31, 2024
Rev Recd Date: Jan. 18, 2024
Publish Date: Feb. 05, 2024

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References(5)

References

[1]	K.B. Hansen, L.P. Wollmuth, D. Bowie, et al., Structure, function, and pharmacology of glutamate receptor ion channels, Pharmacol. Rev. 73 (2021) 298-487 https://doi.org/10.1124/pharmrev.120.000131.
[2]	H. Furukawa, S.K. Singh, R. Mancusso, et al., Subunit arrangement and function in NMDA receptors, Nature 438 (2005) 185-192 https://doi.org/10.1038/nature04089.
[3]	J. Jose, T.F. Meyer, The autodisplay story, from discovery to biotechnical and biomedical applications, Microbiol. Mol. Biol. Rev. 71 (2007) 600-619 https://doi.org/10.1128/MMBR.00011-07.
[4]	K.B. Hansen, K.K. Ogden, S.F. Traynelis, Subunit-selective allosteric inhibition of glycine binding to NMDA receptors, J. Neurosci. 32 (2012) 6197-6208 https://doi.org/10.1523/JNEUROSCI.5757-11.2012.
[5]	F. Yi, T.C. Mou, K.N. Dorsett, et al., Structural basis for negative allosteric modulation of GluN2A-containing NMDA receptors, Neuron 91 (2016) 1316-1329 https://doi.org/10.1016/j.neuron.2016.08.014.