3D-Printed Constructs Deliver Bioactive Cargos to Expedite Cartilage Regeneration

Rong Jiao; Xia Lin; Jingchao Wang; Chunyan Zhu; Jiang Hu; Huali Gao; Kun Zhang

doi:10.1016/j.jpha.2023.12.015

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Rong Jiao, Xia Lin, Jingchao Wang, Chunyan Zhu, Jiang Hu, Huali Gao, Kun Zhang. 3D-Printed Constructs Deliver Bioactive Cargos to Expedite Cartilage Regeneration[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2023.12.015

Citation:

Rong Jiao, Xia Lin, Jingchao Wang, Chunyan Zhu, Jiang Hu, Huali Gao, Kun Zhang. 3D-Printed Constructs Deliver Bioactive Cargos to Expedite Cartilage Regeneration[J]. Journal of Pharmaceutical Analysis. doi: 10.1016/j.jpha.2023.12.015

Citation:

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3D-Printed Constructs Deliver Bioactive Cargos to Expedite Cartilage Regeneration

doi: 10.1016/j.jpha.2023.12.015

Rong Jiao^a,b,
Xia Lin^a,b,
Jingchao Wang^b,
Chunyan Zhu^b,
Jiang Hu^{b
,
,},
Huali Gao^{c
,
,},
Kun Zhang^{a,b
,
,}

a. State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University. No. 22 Shuangyong Road, Nanning, Guangxi 530021, China;
b. Department of Orthopedic Surgery and Department of Medical Ultrasound, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China. No. 32, West Second Section, First Ring Road, Chengdu, 610072, Sichuan, China;
c. Orthopedic Surgery Department, Institute of Arthritis Research in Integrative Medicine, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. No. 540 Xinhua Road, Shanghai 200052, P. R. China

Funds:

This work was supported by National Natural Science Foundation of China (Grant Number: 82022033), Scientific and Technological Innovation Major Base of Guangxi (No.2022-36-Z05) and the program for Shanghai Young Top-Notch Talent.

Received Date: Sep. 23, 2023
Accepted Date: Dec. 19, 2023
Rev Recd Date: Dec. 10, 2023
Available Online: Dec. 22, 2023

Abstract

Abstract

Cartilage is solid connective tissue that recovers slowly from injury, and pain and dysfunction from cartilage damage affect many people. The treatment of cartilage injury is clinically challenging and there is no optimal solution, which is a hot research topic at present. With the rapid development of 3D printing technology in recent years, 3D bioprinting can better mimic the complex microstructure of cartilage tissue and thus enabling the anatomy and functional regeneration of damaged cartilage. This article reviews the methods of 3D printing used to mimic cartilage structures, the selection of cells and biological factors, and the development of bioinks and advances in scaffold structures, with an emphasis on how 3D printing structure provides bioactive cargos in each stage to enhance the effect. Finally, clinical applications and future development of simulated cartilage printing are introduced, which are expected to provide new insights into this field and guide other researchers who are engaged in cartilage repair.
- 3D bioprinting,
- articular cartilage,
- tissue engineering,
- cartilage regeneration

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References(141)

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