An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke

Junfeng Wang; Qibing Liu; Yingbo Li; Yi Pang

doi:10.1016/j.jpha.2023.11.010

Volume 14 Issue 4

Apr. 2024

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Junfeng Wang, Qibing Liu, Yingbo Li, Yi Pang. An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke[J]. Journal of Pharmaceutical Analysis, 2024, 14(4): 100903. doi: 10.1016/j.jpha.2023.11.010

Citation:

Junfeng Wang, Qibing Liu, Yingbo Li, Yi Pang. An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke[J]. Journal of Pharmaceutical Analysis, 2024, 14(4): 100903. doi: 10.1016/j.jpha.2023.11.010

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An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke

doi: 10.1016/j.jpha.2023.11.010

Junfeng Wang^{a,b
,
,},
Qibing Liu^c,d,
Yingbo Li^e,
Yi Pang^{a,f
,
,}

a. Department of Chemistry, The University of Akron, Akron, OH 44325, USA;
b. Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA;
c. Department of Pharmacy, The First Affiliated Hospital of Hainan Medical University, Haikou, 570100, China;
d. Engineering Research Center of Tropical Medicine, Ministry of Education, Hainan Medical University, Haikou, 571199, China;
e. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China;
f. Maurice Morton Institute of Polymer Science, The University of Akron, Akron, OH 44325, USA

Funds:

This work was supported by the National Institute of Health (Grant Nos.: 1R15EB014546-01A1 and K25AG061282). We also thank the Coleman endowment from the University of Akron for partial support.

Received Date: Aug. 05, 2023
Accepted Date: Nov. 21, 2023
Rev Recd Date: Nov. 01, 2023
Publish Date: Nov. 29, 2023

Abstract

Abstract

A two-photon near infrared (NIR) fluorescence turn-on sensor with high selectivity and sensitivity for Zn²⁺ detection has been developed. This sensor exhibits a large Stokes' shift (∼300 nm) and can be excited from 900 to 1000 nm, with an emission wavelength of ∼785 nm, making it ideal for imaging in biological tissues. The sensor's high selectivity for Zn²⁺ over other structurally similar cations, such as Cd²⁺, makes it a promising tool for monitoring zinc ion levels in biological systems. Given the high concentration of zinc in thrombi, this sensor could provide a useful tool for in vivo thrombus imaging.
- Near-infrared,
- Molecular imaging,
- Thrombus,
- Stroke

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References(62)

References

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