Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease: A systematic review

Gopalsamy Rajiv Gandhi; Thiruchenduran Mohana; Kumaraswamy Athesh; Varghese Edwin Hillary; Alan Bruno Silva Vasconcelos; Mariana Nobre Farias de Franca; Monalisa Martins Montalvão; Stanislaus Antony Ceasar; Gnanasekaran Jothi; Gurunagarajan Sridharan; Ricardo Queiroz Gurgel; Baojun Xu

doi:10.1016/j.jpha.2023.09.012

Volume 13 Issue 12

Dec. 2023

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Article Navigation > Journal of Pharmaceutical Analysis > 2023 > 13(12): 1408-1428

Gopalsamy Rajiv Gandhi, Thiruchenduran Mohana, Kumaraswamy Athesh, Varghese Edwin Hillary, Alan Bruno Silva Vasconcelos, Mariana Nobre Farias de Franca, Monalisa Martins Montalvão, Stanislaus Antony Ceasar, Gnanasekaran Jothi, Gurunagarajan Sridharan, Ricardo Queiroz Gurgel, Baojun Xu. Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease: A systematic review[J]. Journal of Pharmaceutical Analysis, 2023, 13(12): 1408-1428. doi: 10.1016/j.jpha.2023.09.012

Citation:

Gopalsamy Rajiv Gandhi, Thiruchenduran Mohana, Kumaraswamy Athesh, Varghese Edwin Hillary, Alan Bruno Silva Vasconcelos, Mariana Nobre Farias de Franca, Monalisa Martins Montalvão, Stanislaus Antony Ceasar, Gnanasekaran Jothi, Gurunagarajan Sridharan, Ricardo Queiroz Gurgel, Baojun Xu. Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease: A systematic review[J]. Journal of Pharmaceutical Analysis, 2023, 13(12): 1408-1428. doi: 10.1016/j.jpha.2023.09.012

Citation:

Gopalsamy Rajiv Gandhi, Thiruchenduran Mohana, Kumaraswamy Athesh, Varghese Edwin Hillary, Alan Bruno Silva Vasconcelos, Mariana Nobre Farias de Franca, Monalisa Martins Montalvão, Stanislaus Antony Ceasar, Gnanasekaran Jothi, Gurunagarajan Sridharan, Ricardo Queiroz Gurgel, Baojun Xu. Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease: A systematic review[J]. Journal of Pharmaceutical Analysis, 2023, 13(12): 1408-1428. doi: 10.1016/j.jpha.2023.09.012

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Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease: A systematic review

doi: 10.1016/j.jpha.2023.09.012

a. Division of Phytochemistry and Drug Design, Department of Biosciences, Rajagiri College of Social Sciences (Autonomous), Kalamaserry, Kochi, 683104, Kerala, India;
b. Department of Biochemistry, Meenakshi Ammal Dental College and Hospital (MAHER), Maduravoyal, 600095, Chennai, Tamil Nadu, India;
c. Department of Biochemistry, Srimad Andavan Arts and Science College (Autonomous), Affiliated to Bharathidasan University, Tiruchirapalli, 620005, Tamil Nadu, India;
d. Division of Plant Molecular Biology and Biotechnology, Department of Biosciences, Rajagiri College of Social Sciences (Autonomous), Kalamaserry, Kochi, 683104, Kerala, India;
e. Laboratory of Biology and Immunology of Cancer and Leishmania, Department of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil;
f. Postgraduate Program in Health Sciences (PPGCS), Federal University of Sergipe (UFS), Campus Prof. João Cardoso Nascimento, Aracaju, CEP 49060.108, Sergipe, Brazil;
g. Programme of Food Science and Technology, Department of Life Sciences, BNU-HKBU United International College, Zhuhai, Guangdong, 519087, China

Funds:

The authors would like to thank Rajagiri College of Social Sciences (Autonomous), Kochi, India for providing extensive research support. This study received funding from Rajagiri College of Social Sciences in the form of seed funding for executing Major Research Projects (Project No.: RCSS/IQAC/BB-S33/2023/133). Two United International College (UIC) research grants provided by BNU-HKBU United International College, Zhuhai, China jointly support this work (Grant Nos.: UICR0200007-23 and UICR202107).

Received Date: Apr. 20, 2023
Accepted Date: Sep. 18, 2023
Rev Recd Date: Sep. 17, 2023
Publish Date: Sep. 22, 2023

Abstract

Abstract

This review aims to identify in vivo studies investigating the potential of plant substances and their natural molecules in managing inflammatory bowel disease (IBD). Specifically, the objective is to examine the impact of these substances on interleukins and other key inflammatory signaling markers. Relevant articles published up to December 2022 were identified through a search of the PubMed, Scopus, Web of Science, and Embase databases. The search used keywords including “inflammatory bowel disease”, “medicinal plants”, “natural molecules”, “anti-inflammatory”, and “ulcerative colitis”, and identified 1,878 potentially relevant articles, of which 89 were included in this review after completion of the selection process. This study provides preclinical data on natural products (NPs) that can potentially treat IBD, including ulcerative colitis. The main actions of these NPs relate to their effects on nuclear factor kappa B (NF-κB), the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway, the regulation of T helper 17/regulatory T cells balance, and oxidative stress. The ability of these NPs to inhibit intestinal inflammation appears to be dependent on lowering levels of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-17, via the Jun N-terminal kinase (JNK)1, NF-κβ-p65, and STAT3 pathways. In addition, NPs were shown to reduce oxidative stress and the severity of ulcerative colitis, as well as increase the activity of antioxidant enzymes. These actions suggest that NPs represent a promising treatment for IBD, and potentially have greater efficacy and safety than current treatments.
- Crohn's disease,
- Inflammation,
- Interleukins,
- Oxidative stress,
- Phytochemicals,
- Ulcerative colitis

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References(129)

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