Online pharmaceutical process analysis of Chinese medicine using a miniature mass spectrometer: Extraction of active ingredients as an example

Wangmin Hu; Junling Hou; Wenjing Liu; Xuan Gu; Yulei Yang; Hongcai Shang; Mei Zhang

doi:10.1016/j.jpha.2023.03.005

Volume 13 Issue 5

May 2023

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Article Navigation > Journal of Pharmaceutical Analysis > 2023 > 13(5): 535-543

Wangmin Hu, Junling Hou, Wenjing Liu, Xuan Gu, Yulei Yang, Hongcai Shang, Mei Zhang. Online pharmaceutical process analysis of Chinese medicine using a miniature mass spectrometer: Extraction of active ingredients as an example[J]. Journal of Pharmaceutical Analysis, 2023, 13(5): 535-543. doi: 10.1016/j.jpha.2023.03.005

Citation:

Wangmin Hu, Junling Hou, Wenjing Liu, Xuan Gu, Yulei Yang, Hongcai Shang, Mei Zhang. Online pharmaceutical process analysis of Chinese medicine using a miniature mass spectrometer: Extraction of active ingredients as an example[J]. Journal of Pharmaceutical Analysis, 2023, 13(5): 535-543. doi: 10.1016/j.jpha.2023.03.005

Citation:

Wangmin Hu, Junling Hou, Wenjing Liu, Xuan Gu, Yulei Yang, Hongcai Shang, Mei Zhang. Online pharmaceutical process analysis of Chinese medicine using a miniature mass spectrometer: Extraction of active ingredients as an example[J]. Journal of Pharmaceutical Analysis, 2023, 13(5): 535-543. doi: 10.1016/j.jpha.2023.03.005

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Online pharmaceutical process analysis of Chinese medicine using a miniature mass spectrometer: Extraction of active ingredients as an example

doi: 10.1016/j.jpha.2023.03.005

a. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, China;
b. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China;
c. Huayi Pharmaceutical Co., Ltd., Beijing, 102600, China

Funds:

This study was supported by Ministry of Science and Technology of the People's Republic of China (Grant No.: 2022YFC3502300), Beijing Natural Science Foundation (Grant No.: L222150), the National Natural Science Foundation of China (Grant No.: 82072247), the second batch of “Ten thousand plan” National High Level Talents Special Support Plan (Grant No.: W02020052), and Beijing University of Chinese Medicine (Grant Nos.: XJYS21005, JY21024, MSGZF-202001, 2022-syjs-05, and 2022-syjs-10). We thank Ms. Ying Wen of the Bacteriology Research Platform of Beijing University of Chinese Medicine for her kind assistance.

Received Date: Nov. 30, 2022
Accepted Date: Mar. 16, 2023
Rev Recd Date: Mar. 13, 2023
Publish Date: Mar. 25, 2023

Abstract

Abstract

The automation of traditional Chinese medicine (TCM) pharmaceuticals has driven the development of process analysis from offline to online. Most of common online process analytical technologies are based on spectroscopy, making the identification and quantification of specific ingredients still a challenge. Herein, we developed a quality control (QC) system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry (mini-MS). It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time. Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata (Fuzi) during decoction were used as examples, and the scientific principle of Fuzi compatibility was also investigated. Finally, the system was verified to work stably at the hourly level for pilot-scale extraction. This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.
- Process analytical technology,
- TCM Pharmaceuticals,
- Miniature mass spectrometry,
- Online analysis

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References(51)

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