Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice

doi: 10.1016/j.jpha.2023.03.004

• Qiuyan Guo^a , 
• Jiangpeng Wu^b,c , 
• Qixin Wang^a , 
• Yuwen Huang^d , 
• Lin Chen^a , 
• Jie Gong^e , 
• Maobo Du^f , 
• Guangqing Cheng^a , 
• Tianming Lu^a , 
• Minghong Zhao^a , 
• Yuan Zhao^g , 
• Chong Qiu^a , 
• Fei Xia^a , 
• Junzhe Zhang^a , 
• Jiayun Chen^a , 
• Feng Qiu^{b ,  ,}  , 
• Jigang Wang^{a,b,c ,  ,} 

• a. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China;

• b. School of Chinese Materia Medica, and State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China;

• c. Department of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong, 518020, China;

• d. College of Food Science and Engineering, Institute of Ocean, Bohai University, Jinzhou, Liaoning, 121013, China;

• e. State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China;

• f. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China;

• g. The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518033, China