Volume 13 Issue 4
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Weilin Zeng, Yingqiu Song, Runze Wang, Rong He, Tianlu Wang. Neutrophil elastase: From mechanisms to therapeutic potential[J]. Journal of Pharmaceutical Analysis, 2023, 13(4): 355-366. doi: 10.1016/j.jpha.2022.12.003
Citation: Weilin Zeng, Yingqiu Song, Runze Wang, Rong He, Tianlu Wang. Neutrophil elastase: From mechanisms to therapeutic potential[J]. Journal of Pharmaceutical Analysis, 2023, 13(4): 355-366. doi: 10.1016/j.jpha.2022.12.003
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Neutrophil elastase: From mechanisms to therapeutic potential

doi: 10.1016/j.jpha.2022.12.003

  • a. Department of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, 110000, China;

  • b. Department of Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, 110000, China

Funds:

This work has been supported by the Liaoning Province Natural Science Foundation (Grant Nos.: 2020-ZLLH-47, 2020-MS-065, 2021-YGJC-02, and 2017225054). Figures in the paper were drawn using Figdraw, and we sincerely thank the free drawing support provided by the Figdraw platform (www.fgdraw.com). We also would like to thank Editage (www.editage.cn) for English language editing.

  • Received Date: Aug. 23, 2022
  • Accepted Date: Dec. 31, 2022
  • Rev Recd Date: Nov. 30, 2022
  • Publish Date: Jan. 07, 2023
    Abstract
  • Neutrophil elastase (NE), a major protease in the primary granules of neutrophils, is involved in microbicidal activity. NE is an important factor promoting inflammation, has bactericidal effects, and shortens the inflammatory process. NE also regulates tumor growth by promoting metastasis and tumor microenvironment remodeling. However, NE plays a role in killing tumors under certain conditions and promotes other diseases such as pulmonary ventilation dysfunction. Additionally, it plays a complex role in various physiological processes and mediates several diseases. Sivelestat, a specific NE inhibitor, has strong potential for clinical application, particularly in the treatment of coronavirus disease 2019 (COVID-19). This review discusses the pathophysiological processes associated with NE and the potential clinical applications of sivelestat.
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