Multimodal integrated strategy for the discovery and identification of quality markers in traditional Chinese medicine

Xiaoyan Lu; Yanyan Jin; Yuzhen Wang; Yunlong Chen; Xiaohui Fan

doi:10.1016/j.jpha.2022.05.001

Volume 12 Issue 5

Nov. 2022

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Xiaoyan Lu, Yanyan Jin, Yuzhen Wang, Yunlong Chen, Xiaohui Fan. Multimodal integrated strategy for the discovery and identification of quality markers in traditional Chinese medicine[J]. Journal of Pharmaceutical Analysis, 2022, 12(5): 701-710. doi: 10.1016/j.jpha.2022.05.001

Citation:

Xiaoyan Lu, Yanyan Jin, Yuzhen Wang, Yunlong Chen, Xiaohui Fan. Multimodal integrated strategy for the discovery and identification of quality markers in traditional Chinese medicine[J]. Journal of Pharmaceutical Analysis, 2022, 12(5): 701-710. doi: 10.1016/j.jpha.2022.05.001

Citation:

Xiaoyan Lu, Yanyan Jin, Yuzhen Wang, Yunlong Chen, Xiaohui Fan. Multimodal integrated strategy for the discovery and identification of quality markers in traditional Chinese medicine[J]. Journal of Pharmaceutical Analysis, 2022, 12(5): 701-710. doi: 10.1016/j.jpha.2022.05.001

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Multimodal integrated strategy for the discovery and identification of quality markers in traditional Chinese medicine

doi: 10.1016/j.jpha.2022.05.001

Xiaoyan Lu^a,b,c,d,
Yanyan Jin^a,
Yuzhen Wang^f,
Yunlong Chen^{e
,
,},
Xiaohui Fan^{a,b,c,d
,
,}

a. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China;
b. Innovation Center in Zhejiang University, State Key Laboratory of Component-Based Chinese Medicine, Hangzhou, 310058, China;
c. Jinhua Institute of Zhejiang University, Jinhua, Zhejiang, 321016, China;
d. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310058, China;
e. Hangzhou Children's Hospital, Hangzhou, 310010, China;
f. Department of Pharmacy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China

Funds:

This work was supported by the National Natural Science Foundation of China (Grant No.: 81973701), Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (Grant No.: ZYYCXTD-D-202002), and Westlake Laboratory (Westlake Laboratory of Life Sciences and Biomedicine).

Received Date: Oct. 06, 2021
Accepted Date: May 11, 2022
Rev Recd Date: Apr. 21, 2022
Publish Date: May 16, 2022

Abstract

Abstract

With the modernization and internationalization of traditional Chinese medicine (TCM), the requirement for quality control has increased. The quality marker (Q-marker) is an important standard in this field and has been implemented with remarkable success in recent years. However, the establishment of Q-markers remains fragmented and the process lacks systematicity, resulting in inconsistent quality control and insufficient correlation with clinical efficacy and safety of TCM. This review introduces four multimodal integrated approaches that contribute to the discovery of more comprehensive and accurate Q-markers, thus aiding in the establishment of new quality control patterns based on the characteristics and principles of TCM. These include the whole-process quality control strategy, chemical-activity-based screening method, efficacy, safety, and consistent combination strategy, and TCM theory-guided approach. Furthermore, methodologies and representative examples of these strategies are described, and important future directions and questions in this field are also proposed.
- Traditional Chinese medicine (TCM),
- Quality marker (Q-marker),
- Multimodal integrated strategy,
- Quality control systems

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References(79)

References

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