MIL-53-based homochiral metal-organic framework as a stationary phase for open-tubular capillary electrochromatography

Xiaodong Sun; Bing Niu; Qi Zhang; Qin Chen

doi:10.1016/j.jpha.2021.12.004

Volume 12 Issue 3

Jun. 2022

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Article Navigation > Journal of Pharmaceutical Analysis > 2022 > 12(3): 509-516

Xiaodong Sun, Bing Niu, Qi Zhang, Qin Chen. MIL-53-based homochiral metal-organic framework as a stationary phase for open-tubular capillary electrochromatography[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 509-516. doi: 10.1016/j.jpha.2021.12.004

Citation:

Xiaodong Sun, Bing Niu, Qi Zhang, Qin Chen. MIL-53-based homochiral metal-organic framework as a stationary phase for open-tubular capillary electrochromatography[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 509-516. doi: 10.1016/j.jpha.2021.12.004

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MIL-53-based homochiral metal-organic framework as a stationary phase for open-tubular capillary electrochromatography

doi: 10.1016/j.jpha.2021.12.004

Xiaodong Sun^a,b,
Bing Niu^b,
Qi Zhang^{c
,
,},
Qin Chen^{b
,
,}

a. School of Medicine, Shanghai University, Shanghai, 200444, China;
b. School of Life Sciences, Shanghai University, Shanghai, 200444, China;
c. School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, 212013, China

Funds:

This study was funded by the National Natural Science Foundation of China (Grant No.: 82003705).

Received Date: Jun. 08, 2021
Accepted Date: Dec. 16, 2021
Rev Recd Date: Nov. 27, 2021
Publish Date: Dec. 20, 2021

Abstract

Abstract

Homochiral metal-organic frameworks (MOFs) have attracted considerable attention in many fields of research, such as chiral catalysis and chiral chromatography. However, only few homochiral MOFs can be effectively used in capillary electrochromatography (CEC) and their performances are far from adequate. In this study, we successfully synthesized achiral nanocrystalline MIL-53. A facile post-synthetic modification strategy was then implemented to functionalize the product, yielding a homochiral MOF:l-His-NH-MIL-53. This MOF was then employed as a chiral coating in open-tubular CEC mode (OT-CEC), and, as such, it exhibited high enantioselectivities for several racemic drugs. The homochiral MOF and the fabricated capillary coating were systematically characterized using transmission electron microscopy, scanning electron microscopy (with energy-dispersive X-ray spectrometry), Fourier-transform infrared spectroscopy, X-ray diffractometry, thermogravimetric analysis, circular dichroism spectroscopy, Brunauer-Emmett-Teller surface area measurements, and X-ray photoelectron spectroscopy. This study is expected to provide a new strategy for the design and establishment of MOF-based chiral OT-CEC systems.
- Homochiral MOF,
- l-His-NH-MIL-53,
- Chiral stationary phase,
- Capillary electrochromatography,
- Enantioseparation

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References(33)

References

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