Rapid and sensitive analysis of trace β-blockers by magnetic solid-phase extraction coupled with Fourier transform ion cyclotron resonance mass spectrometry

Xue Xiao; Kaili He; Ya-Jun Hou; Zhangmin Xiang; Yunyun Yang

doi:10.1016/j.jpha.2021.12.001

Volume 12 Issue 2

May 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Pharmaceutical Analysis > 2022 > 12(2): 293-300

Xue Xiao, Kaili He, Ya-Jun Hou, Zhangmin Xiang, Yunyun Yang. Rapid and sensitive analysis of trace β-blockers by magnetic solid-phase extraction coupled with Fourier transform ion cyclotron resonance mass spectrometry[J]. Journal of Pharmaceutical Analysis, 2022, 12(2): 293-300. doi: 10.1016/j.jpha.2021.12.001

Citation:

Xue Xiao, Kaili He, Ya-Jun Hou, Zhangmin Xiang, Yunyun Yang. Rapid and sensitive analysis of trace β-blockers by magnetic solid-phase extraction coupled with Fourier transform ion cyclotron resonance mass spectrometry[J]. Journal of Pharmaceutical Analysis, 2022, 12(2): 293-300. doi: 10.1016/j.jpha.2021.12.001

Citation:

Xue Xiao, Kaili He, Ya-Jun Hou, Zhangmin Xiang, Yunyun Yang. Rapid and sensitive analysis of trace β-blockers by magnetic solid-phase extraction coupled with Fourier transform ion cyclotron resonance mass spectrometry[J]. Journal of Pharmaceutical Analysis, 2022, 12(2): 293-300. doi: 10.1016/j.jpha.2021.12.001

PDF( 1877 KB)

Rapid and sensitive analysis of trace β-blockers by magnetic solid-phase extraction coupled with Fourier transform ion cyclotron resonance mass spectrometry

doi: 10.1016/j.jpha.2021.12.001

Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology, Guangdong Provincial Engineering Research Center for Ambient Mass Spectrometry, Institute of Analysis, Guangdong Academy of Sciences (China National Analytical Center, Guangzhou), Guangzhou, 510070, China

Funds:

This work was financially supported by the National Natural Science Foundation of China (Grant Nos.: 21976168, 22127810, and 22004113), Key Research and Development Program of Guangdong Province (Grant No.: 2020B1111350002), Guangdong Basic and Applied Basic Research Foundation (Grant No.: 2019A1515110420), and GDAS' Project of Science and Technology Development (Grant No.: 2021GDASYL-20210103034).

Received Date: Sep. 25, 2020
Accepted Date: Dec. 03, 2021
Rev Recd Date: Dec. 03, 2021
Publish Date: Dec. 05, 2021

Abstract

Abstract

A rapid and sensitive method for analyzing trace β-blockers in complex biological samples, which involved magnetic solid-phase extraction (MSPE) coupled with Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS), was developed. Novel nanosilver-functionalized magnetic nanoparticles with an interlayer of poly(3,4-dihydroxyphenylalanine) (polyDOPA@Ag-MNPs) were synthesized and used as MSPE adsorbents to extract trace β-blockers from biological samples. After extraction, the analytes loaded on the polyDOPA@Ag-MNPs were desorbed using an organic solvent and analyzed by FTICR-MS. The method was rapid and sensitive, with a total detection procedure of less than 10 min as well as limits of detection and quantification in the ranges of 3.5–6.8 pg/mL and 11.7–22.8 pg/mL, respectively. The accuracy of the method was also desirable, with recoveries ranging from 80.9% to 91.0% following the detection of analytes in human blood samples. All the experimental results demonstrated that the developed MSPE-FTICR-MS method was suitable for the rapid and sensitive analysis of trace β-blockers in complex biological samples.

FullText(HTML)

References(39)

References

M. Caban, P. Stepnowski, M. Kwiatkowski, et al., Determination of β-blockers and β-agonists using gas chromatography and gas chromatography-mass spectrometry - A comparative study of the derivatization step, J. Chromatogr. A 1218 (2011) 8110-8122

O. Lamy, A. Jenzer-Closuit, P. Burckhardt, Hypercalcaemia of malignancy: an undiagnosed and undertreated disease, J. Intern. Med. 250 (2001) 73-79

A. Mozayani, G. Singer P Fau - Jones, G. Jones, Distribution of metoprolol enantiomers in a fatal overdose, J. Anal. Toxicol. 19 (1995) 519-521

T.P. Rohrig, W.N. Rundle Da Fau - Leifer, W.N. Leifer, Fatality resulting from metoprolol overdose, J. Anal. Toxicol. 11 (1987) 231-232

N. Fucci, C. Offidani, An unusual death by propranolol ingestion, Am. J. Forensic Med. Pathol. 21 (2000) 56-58

J. Jones, D.J. Hart, R.E. Ballard, Photoelectron spectra of quaternary salts in solution, J. Mol. Struct. 80 (1982) 213-216

S. Asadi, H. Tabani, S. Nojavan, Application of polyacrylamide gel as a new membrane in electromembrane extraction for the quantification of basic drugs in breast milk and wastewater samples, J Pharm Biomed Anal 151 (2018) 178-185

A. Mahmoudi, M. Rajabi, Selective determination of some beta-blockers in urine and plasma samples using continuous flow membrane microextraction coupled with high performance liquid chromatography, J Chromatogr B 1128 (2019) 121768

V.M.F. Gonçalves, P. Rodrigues, C. Ribeiro, et al., Quantification of alprenolol and propranolol in human plasma using a two-dimensional liquid chromatography (2D-LC), J. Pharm. Biomed. Anal. 141 (2017) 1-8

J.V. Shah, D.P. Patel, P.A. Shah, et al., Simultaneous quantification of atenolol and chlorthalidone in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry, Biomed. Chromatogr. 30 (2016) 208-216

J.Q. Cheng, T. Liu, X.M. Nie, et al., Analysis of 27 beta-Blockers and Metabolites in Milk Powder by High Performance Liquid Chromatography Coupled to Quadrupole Orbitrap High-Resolution Mass Spectrometry, Molecules 24 (2019) 820

R. AminiTabrizi, D. Hassan, R. Davis, et al., Analysis of beta-blocker bioconcentration in brown planaria (Girardia dorotocephala) and its effects on regeneration, Environ. Sci. Pollut. Res. Int. 26 (2019) 27435-27443

M.A. Rosa, H.D. De Faria, D.T. Carvalho, et al., Biological sample preparation by using restricted-access nanoparticles prepared from bovine serum albumin: application to liquid chromatographic determination of beta-blockers, Mikrochim Acta 186 (2019) 647

V. Kertesz, T.M. Weiskittel, M. Vavrek, et al., Extraction efficiency and implications for absolute quantitation of propranolol in mouse brain, liver and kidney tissue sections using droplet-based liquid microjunction surface sampling high-performance liquid chromatography/electrospray ionization tandem mass spectrometry, Rapid Commun Mass Spectrom 30 (2016) 1705-1712

H. He, L. Li, L. Zhao, et al., An improved HPLC-MS/MS method for simultaneous quantification of propranolol and its two phase I metabolites in plasma of infants with hemangioma and its application to a comparative study of plasma concentrations, RSC Advances 8 (2018) 37286-37294

X. Xiao, M.-M. Zhang, Z.-Q. Wang, Determination of β-Blockers in Bovine and Porcine Tissues and Bovine Milk by High-Performance Liquid Chromatography - Tandem Mass Spectrometry, Anal. Lett. 52 (2018) 439-451

A. Jakubus, M. Gromelski, K. Jagiello, et al., Dispersive solid-phase extraction using multi-walled carbon nanotubes combined with liquid chromatography-mass spectrometry for the analysis of β-blockers: Experimental and theoretical studies, Microchem. J. 146 (2019) 258-269

H.A. Al Shaker, N.A. Qinna, H. Al Hroub, et al., RP-HPLC-UV method for the quantification of propranolol in rat's serum and Krebs buffer using one-step protein precipitation, Acta Chromatogr. (2017) 1-6

G. Castro, I. Carpinteiro, I. Rodriguez, et al., Determination of cardiovascular drugs in sewage sludge by matrix solid-phase dispersion and ultra-performance liquid chromatography tandem mass spectrometry, Anal Bioanal Chem 410 (2018) 6807-6817

J.M. Peña-Herrera, N. Montemurro, D. Barceló, et al., Development and validation of an analytical method for determination of pharmaceuticals in fish muscle based on QuEChERS extraction and SWATH acquisition using LC-QTOF-MS/MS system, Talanta 199 (2019) 370-379

S. Fan, J.H. Zou, H. Miao, et al., Simultaneous and confirmative detection of multi-residues of β₂-agonists and beta-blockers in urine using LC-MS/MS/MS coupled with beta-receptor molecular imprinted polymer SPE clean-up, Food Addit Contam A 30 (2013) 2093-2101

X. Hu, J. Pan, Y. Hu, et al., Preparation and evaluation of propranolol molecularly imprinted solid-phase microextraction fiber for trace analysis of beta-blockers in urine and plasma samples, J Chromatogr A 1216 (2009) 190-197

T. Ballesteros-Esteban, E.M. Reyes-Gallardo, R. Lucena, et al., Determination of propranolol and carvedilol in urine samples using a magnetic polyamide composite and LC-MS/MS, Bioanalysis 8 (2016) 2115-2123

S. Jamshidi, M.K. Rofouei, G. Thorsen, Using magnetic core-shell nanoparticles coated with an ionic liquid dispersion assisted by effervescence powder for the micro-solid-phase extraction of four beta blockers from human plasma by ultra high performance liquid chromatography with mass spectrometry detection, J. Sep. Sci. 42 (2019) 698-705

A.A. Asgharinezhad, H. Ebrahimzadeh, F. Mirbabaei, et al., Dispersive micro-solid-phase extraction of benzodiazepines from biological fluids based on polyaniline/magnetic nanoparticles composite, Anal Chim Acta 844 (2014) 80-89

H. Yan, M. Gao, C. Yang, et al., Ionic liquid-modified magnetic polymeric microspheres as dispersive solid phase extraction adsorbent: a separation strategy applied to the screening of sulfamonomethoxine and sulfachloropyrazine from urine, Anal Bioanal Chem 406 (2014) 2669-2677

B.P. Lee, P.B. Messersmith, J.N. Israelachvili, et al., Mussel-Inspired Adhesives and Coatings, Annu Rev Mater Res 41 (2011) 99-132

Y. Ai, J. Nie, G. Wu, et al., The DOPA-functionalized bioadhesive with properties of photocrosslinked and thermoresponsive, J. Appl. Polym. Sci. 131 (2014) 41102

X. Xiao, J. Wu, Z. Li, et al., Enantioseparation and sensitive analysis of ofloxacin by poly(3,4-dihydroxyphenylalanine) functionalized magnetic nanoparticles-based solid phase extraction in combination with on-line concentration capillary electrophoresis, J Chromatogr A 1587 (2019) 14-23

H. Lee, J. Rho, P.B. Messersmith, Facile Conjugation of Biomolecules onto Surfaces via Mussel Adhesive Protein Inspired Coatings, Adv. Mater. 21 (2009) 431-434

B. Yang, C. Lim, D.S. Hwang, et al., Switch of Surface Adhesion to Cohesion by Dopa-Fe³⁺ Complexation, in Response to Microenvironment at the Mussel Plaque/Substrate Interface, Chem. Mater. 28 (2016) 7982-7989

J. Zhou, P. Wang, C. Wang, et al., Versatile Core-Shell Nanoparticle@Metal-Organic Framework Nanohybrids: Exploiting Mussel-Inspired Polydopamine for Tailored Structural Integration, ACS Nano 9 (2015) 6951-6960

X. Zhong, K. Yang, Z. Dong, et al., Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer, Adv. Funct. Mater. 25 (2015) 7327-7336

H. Wen, P. Jiang, Y. Hu, et al., Synthesis of Au@Ag core-shell nanostructures with a poly(3,4-dihydroxy-L-phenylalanine) interlayer for surface-enhanced Raman scattering imaging of epithelial cells, Mikrochim Acta 185 (2018) 353

Y. Hu, D. Wang, G. Li, Mussel inspired redox surface for one step visual and colorimetric detection of Hg²⁺ during the formation of Ag@DOPA@Hg nanoparticles, Anal. Methods 7 (2015) 6103-6108

R. Subair, B.P. Tripathi, P. Formanek, et al., Polydopamine modified membranes with in situ synthesized gold nanoparticles for catalytic and environmental applications, Chem. Eng. J. 295 (2016) 358-369

S. Xuan, Y.-X.J. Wang, J.C. Yu, et al., Tuning the Grain Size and Particle Size of Superparamagnetic Fe₃O₄ Microparticles, Chem. Mater. 21 (2009) 5079-5087

Y. Liu, K. Ai, L. Lu, Polydopamine and its derivative materials: synthesis and promising applications in energy, environmental, and biomedical fields, Chem Rev 114 (2014) 5057-5115

M. Caban, N. Migowska, P. Stepnowski, et al., Matrix effects and recovery calculations in analyses of pharmaceuticals based on the determination of β-blockers and β-agonists in environmental samples, J Chromatogr A 1258 (2012) 117-127

Relative Articles

Supplements(0)

Cited By

Proportional views