Volume 12 Issue 2
May  2022
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Article Navigation >  Journal of Pharmaceutical Analysis  > 2022  >  12(2): 221-231
RamaRao Malla, Rakshmitha Marni, Anindita Chakraborty, Mohammad Amjad Kamal. Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer[J]. Journal of Pharmaceutical Analysis, 2022, 12(2): 221-231. doi: 10.1016/j.jpha.2021.11.004
Citation: RamaRao Malla, Rakshmitha Marni, Anindita Chakraborty, Mohammad Amjad Kamal. Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer[J]. Journal of Pharmaceutical Analysis, 2022, 12(2): 221-231. doi: 10.1016/j.jpha.2021.11.004
shu

Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer

doi: 10.1016/j.jpha.2021.11.004

  • a. Cancer Biology Lab, Department of Biochemistry and Bioinformatics, Institute of Science, Gandhi Institute of Technology and Management, Visakhapatnam, 530045, India;

  • b. Radiation Biology, UGC-DAE-CSR, Kolkata Centre, Kolkata, 700098, India;

  • c. King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia;

  • d. Enzymoics, Hebersham, Novel Global Community Educational Foundation, New South Wales, 2770, Australia

Funds:

This work is supported by UGC-DAE-CSR, Kolkata (Grant No.: KC/CRS/19/RB-04/1047).

  • Received Date: Jul. 11, 2020
  • Accepted Date: Nov. 08, 2021
  • Rev Recd Date: Nov. 05, 2021
  • Publish Date: Nov. 10, 2021
    Abstract
  • Breast cancer is one of the leading causes of cancer-related deaths in women worldwide. It is a cancer that originates from the mammary ducts and involves mutations in multiple genes. Recently, the treatment of breast cancer has become increasingly challenging owing to the increase in tumor heterogeneity and aggressiveness, which gives rise to therapeutic resistance. Epidemiological, population-based, and hospital-based case-control studies have demonstrated an association between high intake of certain Allium vegetables and a reduced risk in the development of breast cancer. Diallyl disulfide (DADS) and diallyl trisulfide (DATS) are the main allyl sulfur compounds present in garlic, and are known to exhibit anticancer activity as they interfere with breast cancer cell proliferation, tumor metastasis, and angiogenesis. The present review highlights multidrug resistance mechanisms and their signaling pathways in breast cancer. This review discusses the potential anticancer activities of DADS and DATS, with emphasis on drug resistance in triple-negative breast cancer (TNBC). Understanding the anticancer activities of DADS and DATS provides insights into their potential in targeting drug resistance mechanisms of TNBC, especially in clinical studies.
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  • R. R. Malla, S. Kumari, M. M. Gavara, etal., A perspective on the diagnostics, prognostics, and therapeutics of microRNAs of triple-negative breast cancer, Biophys. Rev. 11 (2019) 227-234
    M. Nedeljković, A. Damjanović, Mechanisms of chemotherapy resistance in triple-negative breast cancer-how we can rise to the challenge, Cells 8 (2019) E957
    L. Luo, W. Gao, J. Wang, etal., Study on the mechanism of cell cycle checkpoint Kinase 2 (CHEK2) gene dysfunction in chemotherapeutic drug resistance of triple negative breast cancer cells, Med. Sci. Monit. 24 (2018) 3176-3183
    S. Shu, C. Y. Lin, H. H. He, etal., Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer, Nature 529 (2016) 413-417
    C. Mani, S. Jonnalagadda, J. Lingareddy, etal., Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells, Breast Cancer Res. 21 (2019) 104
    X. Chen, K. H. Low, A. Alexander, etal., Cyclin E overexpression sensitizes triple-negative breast cancer to Wee1 Kinase inhibition, Clin .Cancer Res. 24 (2018) 6594-6610
    K. L. Thu, J. Silvester, M. J. Elliott, etal., Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer, Proc. Natl. Acad. Sci. USA 115 (2018) E1570-E1577
    T. M. MacDonald, L. N. Thomas, E. Daze, etal., Prolactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells, Am.J .Cancer Res. 9 (2019) 1484-1503
    P. M. M. Ozawa, F. Alkhilaiwi, I. J. Cavalli, etal., Extracellular vesicles from triple-negative breast cancer cells promote proliferation and drug resistance in non-tumorigenic breast cells, Breast Cancer Res.Treat. 172 (2018) 713-723
    C. K. Das, B. Linder, F. Bonn, etal., BAG3 overexpression and cytoprotective autophagy mediate apoptosis resistance in chemoresistant breast cancer cells, Neoplasia 20 (2018) 263-279
    C. C. Cheng, L. H. Shi, X. J. Wang, etal., Stat3/Oct-4/c-Myc signal circuit for regulating stemness-mediated doxorubicin resistance of triple-negative breast cancer cells and inhibitory effects of WP1066, Int. J. Oncol. 53 (2018) 339-348
    Y. Liu, M. L. Burness, R. Martin-Trevino, etal., RAD51 mediates resistance of cancer stem cells to PARP inhibition in triple-negative breast cancer, Clin .Cancer Res. 23 (2017) 514-522
    D. R. Chen, D. Y. Lu, H. Y. Lin, etal., Mesenchymal stem cell-induced doxorubicin resistance in triple negative breast cancer, Biomed. Res. Int. 2014 (2014) 532161
    W. L. Yeh, C. F. Tsai, D. R. Chen, Peri-foci adipose-derived stem cells promote chemoresistance in breast cancer, Stem Cell Res. Ther. 8 (2017) 177
    Z. Wang, N. Wang, W. Li, etal., Caveolin-1 mediates chemoresistance in breast cancer stem cells via β-catenin/ABCG2 signaling pathway, Carcinogenesis 35 (2014) 2346-2356
    I. G. Ryoo, B. H. Choi, S. K. Ku, etal., High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance, Redox Biol. 17 (2018) 246-258
    R. Chakravarthy, K. Mnich, A. M. Gorman, Nerve growth factor (NGF)-mediated regulation of p75NTR expression contributes to chemotherapeutic resistance in triple negative breast cancer cells, Biochem .Biophys. Res. Commun. 478 (2016) 1541-1547
    I. N. Sari, L. T. H. Phi, N. Jun, etal., Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells, Cells 7 (2018)
    P. Bhateja, M. Cherian, S. Majumder, etal., The hedgehog signaling pathway: a viable target in breast cancer?, Cancers (Basel) 11 (2019) E1126
    D. J. Azzam, D. Zhao, J. Sun, etal., Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses, EMBO Mol. Med. 5 (2013) 1502-1522
    B. Darvishi, L. Farahmand, S. Z. Eslami, etal., NF-κB as the main node of resistance to receptor tyrosine kinase inhibitors in triple-negative breast cancer, Tumour Biol. 39 (2017) 1010428317706919
    H. Song, D. Li, T. Wu, etal., MicroRNA-301b promotes cell proliferation and apoptosis resistance in triple-negative breast cancer by targeting CYLD, BMB Rep. 51 (2018) 602-607
    J. Niu, A. Xue, Y. Chi, etal., Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer, Oncogene 35 (2016) 1302-1313
    L. Chen, L. Y. Bourguignon, Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells, Mol. Cancer 13 (2014) 52
    L. De Mattos-Arruda, G. Bottai, P. G. Nuciforo, etal., MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients, Oncotarget 6 (2015) 37269-37280
    H. Korkaya, G. I. Kim, A. Davis, etal., Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population, Mol. Cell 47 (2012) 570-584
    L. H. Zhang, A. J. Yang, M. Wang, etal., Enhanced autophagy reveals vulnerability of P-gp mediated epirubicin resistance in triple negative breast cancer cells, Apoptosis 21 (2016) 473-488
    S. Yin, L. Xu, R. D. Bonfil, etal., Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer, Mol. Cancer Ther. 12 (2013) 491-498
    K. Wang, X. Zhu, K. Zhang, etal., Interleukin-6 contributes to chemoresistance in MDA-MB-231 cells via targeting HIF-1α, J. Biochem. Mol. Toxicol. 32 (2018) e22039
    M. Kalimutho, D. Sinha, D. Mittal, etal., Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8(+) T-cells infiltration in triple-negative breast cancer, J. Exp. Clin. Cancer Res. 38 (2019) 85
    M. G. Mendoza-Rodríguez, J. T. Ayala-Sumuano, L. García-Morales, etal., IL-1β inflammatory cytokine-induced TP63 isoform ΔNP63α signaling cascade contributes to cisplatin resistance in human breast cancer cells, Int. J. Mol. Sci. 20 (2019)
    R. B. Penney, D. Roy, Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer, Biochim. Biophys. Acta 1836 (2013) 60-79
    L. Wang, C. Yang, X. B. Liu, etal., B7-H4 overexpression contributes to poor prognosis and drug-resistance in triple-negative breast cancer, Cancer Cell Int. 18 (2018) 100
    D. J. Newman, G. M. Cragg, Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019, J. Nat. Prod. 83 (2020) 770-803
    L. L. Koteswari, S. Kumari, A. B. Kumar, etal., A comparative anticancer study on procyanidin C1 against receptor positive and receptor negative breast cancer, Nat. Prod. Res. (2019) 1-8
    N. Mamadalieva, N. Mamedov. Taxus brevifolia a High-Value Medicinal Plant, as a Source of Taxol. Medicinal and Aromatic Plants of North America: Springer; 2020. p. 201-218
    M. A. Taher, M. A. B. Nyeem, M. M. Billah, etal., Vinca alkaloid-the second most used alkaloid for cancer treatment-A review, Inter. J. Physiol. Nutr. Phys. Educ. 2 (2017) 723-727
    M. A. Kalam, A. H. Malik, A. H. Ganie, etal., Medicinal importance of Papra (Podophyllum hexandrum Royle) in Unani System of Medicine, J.Complement.Integ.Med. (2021)
    M. S. Subramanian, G. Nandagopal MS, S. Amin Nordin, etal., Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate, Molecules 25 (2020) 4111
    S. H. Omar, N. A. Al-Wabel, Organosulfur compounds and possible mechanism of garlic in cancer, Saudi. Pharm. J. 18 (2010) 51-58
    L. D. Lawson, S. M. Hunsaker, Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods, Nutrients 10 (2018)
    S. A. Almatroodi, M. A. Alsahli, A. Almatroudi, etal., Garlic and its Active Compounds: A Potential Candidate in The Prevention of Cancer by Modulating Various Cell Signalling Pathways, Anticancer Agents Med. Chem. 19 (2019) 1314-1324
    Y. Liu, A. Li, X. Feng, etal., Pharmacological Investigation of the anti-Inflammation and anti-oxidation activities of diallyl disulfide in a rat emphysema model induced by cigarette smoke extract, Nutrients 10 (2018) E79
    H. He, Y. Ma, H. Huang, etal., A comprehensive understanding about the pharmacological effect of diallyl disulfide other than its anti-carcinogenic activities, Eur. J. Pharmacol. 893 (2021) 173803
    A. Bordia, S. K. Verma, K. C. Srivastava, Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease, Prostaglandins Leukot. Essent. Fatty Acids 58 (1998) 257-263
    I. C. Lee, S. H. Kim, H. S. Baek, etal., Protective effects of diallyl disulfide on carbon tetrachloride-induced hepatotoxicity through activation of Nrf2, Environ. Toxicol. 30 (2015) 538-548
    A. Hosseinzadeh, D. Jafari, T. Kamarul, etal., Evaluating the protective effects and mechanisms of diallyl disulfide on interlukin-1β-induced oxidative stress and mitochondrial apoptotic signaling pathways in cultured chondrocytes, J. Cell. Biochem. 118 (2017) 1879-1888
    Y.-R. Wu, L. Li, X.-C. Sun, etal., Diallyl disulfide improves lipid metabolism by inhibiting PCSK9 expression and increasing LDL uptake via PI3K/Akt-SREBP2 pathway in HepG2 cells, Nutr. Metab. Cardiovasc. Dis. 31 (2021) 322-332
    P. Goudappala, C. Y. Gowda, R. T. Kashinath, Diallyl disulfide regulates purine metabolism and their metabolites in diabetes mellitus, Indian J. Physiol. Pharmacol. 65 (2021) 28-34
    P. Mikaili, S. Maadirad, M. Moloudizargari, etal., Therapeutic uses and pharmacological properties of garlic, shallot, and their biologically active compounds, Iran. J. Basic Med. Sci. 16 (2013) 1031
    A. A. Shaaban, D. S. El-Agamy, Cytoprotective effects of diallyl trisulfide against valproate-induced hepatotoxicity: new anticonvulsant strategy, Naunyn Schmiedebergs Arch. Pharmacol. 390 (2017) 919-928
    L.-Y. Chen, Q. Chen, X.-J. Zhu, etal., Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism, Int. Immunopharmacol. 36 (2016) 23-30
    C.-T. Liu, H. Hse, C.-K. Lii, etal., Effects of garlic oil and diallyl trisulfide on glycemic control in diabetic rats, Eur. J. Pharmacol. 516 (2005) 165-173
    X. Zhu, F. Zhang, L. Zhou, etal., Diallyl trisulfide attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic oxidative stress in rats, Naunyn Schmiedebergs Arch. Pharmacol. 387 (2014) 445-455
    B. L. Predmore, K. Kondo, S. Bhushan, etal., The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability, Am. J. Physiol. Heart Circ. Physiol. 302 (2012) H2410-2418
    G. Desai, M. Schelske-Santos, C. M. Nazario, etal., Onion and garlic intake and breast cancer, a case-control study in Puerto Rico, Nutr. Cancer 72 (2020) 791-800
    A. Pourzand, A. Tajaddini, S. Pirouzpanah, etal., Associations between dietary Allium vegetables and risk of breast cancer: a hospital-based matched case-control study, J. Breast Cancer 19 (2016) 292-300
    Y. Li, S. Li, X. Meng, etal., Dietary natural products for prevention and treatment of breast cancer, Nutrients 9 (2017) E728
    I. Henao Castañeda, J. A. Pereañez, L. M. Preciado, etal., Sulfur Compounds as Inhibitors of Enzymatic Activity of a Snake Venom Phospholipase A2: Benzyl 4-nitrobenzenecarbodithioate as a Case of Study, Molecules 25 (2020) 1373
    X. Wu, F. Kassie, V. Mersch-Sundermann, Induction of apoptosis in tumor cells by naturally occurring sulfur-containing compounds, Mutat. Res. Rev. Mutat. Res. 589 (2005) 81-102
    S. H. Omar, N. A. Al-Wabel, Organosulfur compounds and possible mechanism of garlic in cancer, Saudi Pharm. J. 18 (2010) 51-58
    P. Thejass, G. Kuttan, Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by diallyl disulfide (DADS), Life Sci. 80 (2007) 515-521
    S. V. Singh, A. A. Powolny, S. D. Stan, etal., Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice, Cancer Res. 68 (2008) 9503-9511
    A. Malki, M. El-Saadani, A. S. Sultan, Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells, Cancer Biol. Ther. 8 (2009) 2175-2185
    X. Xie, X. Huang, H. Tang, etal., Diallyl Disulfide Inhibits Breast Cancer Stem Cell Progression and Glucose Metabolism by Targeting CD44/PKM2/AMPK Signaling, Curr. Cancer Drug Targets 18 (2018) 592-599
    H. Nakagawa, K. Tsuta, K. Kiuchi, etal., Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines, Carcinogenesis 22 (2001) 891-897
    R. Jan, G. E. Chaudhry, Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics, Adv. Pharm. Bull. 9 (2019) 205-218
    G. P. Feeney, R. J. Errington, M. Wiltshire, etal., Tracking the cell cycle origins for escape from topotecan action by breast cancer cells, Br. J. Cancer 88 (2003) 1310-1317
    Y. Nishiguchi, N. Oue, R. Fujiwara-Tani, etal., Role of metastasis-related genes in cisplatin chemoresistance in gastric cancer, Int. J. Mol. Sci. 21 (2019) E254
    M. T. Puccinelli, S.D Stan, Dietary bioactive diallyl trisulfide in cancer prevention and treatment, Int. J. Mol. Sci. 18 (2017) E1645
    E. R. Hahm, S. V. Singh, Diallyl trisulfide inhibits estrogen receptor-α activity in human breast cancer cells, Breast Cancer Res.Treat. 144 (2014) 47-57
    H. A. Abdel-Hafiz, Epigenetic Mechanisms of Tamoxifen Resistance in Luminal Breast Cancer, Diseases 5 (2017)
    C. H.Lee, Reversing agents for ATP-binding cassette drug transporters, Methods Mol. Biol. 596 (2010) 325-340
    Y. S. Hong, Y. A. Ham, J. H. Choi, etal., Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines, Exp. Mol. Med. 32 (2000) 127-134
    S. Ohkubo, L. Dalla Via, S. Grancara, etal., The antioxidant, aged garlic extract, exerts cytotoxic effects on wild-type and multidrug-resistant human cancer cells by altering mitochondrial permeability, Int. J. Oncol. 53 (2018) 1257-1268
    J. Huang, B. Yang, T. Xiang, etal., Diallyl disulfide inhibits growth and metastatic potential of human triple-negative breast cancer cells through inactivation of the β-catenin signaling pathway, Mol. Nutr. Food Res. 59 (2015) 1063-1075
    T. Xiong, X. W. Liu, X. L. Huang, etal., Tristetraprolin: a novel target of diallyl disulfide that inhibits the progression of breast cancer, Oncol. Lett. 15 (2018) 7817-7827
    M. Ciocci, E. Iorio, F. Carotenuto, etal., H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair, Oncotarget 7 (2016) 84338-84358
    S. V. Talluri, G. Kuppusamy, V. V. Karri, etal., Application of quality-by-design approach to optimize diallyl disulfide-loaded solid lipid nanoparticles, Artif. Cells Nanomed. Biotechnol. 45 (2017) 474-488
    V. T. Siddhartha, S. Pindiprolu, P. K. Chintamaneni, etal., RAGE receptor targeted bioconjuguate lipid nanoparticles of diallyl disulfide for improved apoptotic activity in triple negative breast cancer: in vitro studies, Artif. Cells Nanomed. Biotechnol. 46 (2018) 387-397
    L.M. Yu, S. Li, X.L.Tang, etal., Diallyl trisulfide ameliorates myocardial ischemia-reperfusion injury by reducing oxidative stress and endoplasmic Reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 activation, Apoptosis 22 (2017) 942-954
    Y.G. Li, Z.Y. Wang, J.M. Li, etal., Diallyl disulfide suppresses FOXM1-mediated proliferation and invasion in osteosarcoma by upregulating miR-134, J. Cell. Biochem. (2019) 7286-7296
    Y.P.Liu, P.T. Zhu, Y.Y. Wang, etal., Antimetastatic therapies of the polysulfide diallyl tisulfide against triple-negative breast bancer (TNBC) via suppressing MMP2/9 by blocking NF-κB and ERK/MAPK signaling pathways, PLoS One 10 (2015) e0123781
    Y.P.Liu, Y. Zhao, Z.H. Wei, etal., Targeting thioredoxin system with an organosulfur compound, diallyl trisulfide (DATS), attenuates progression and metastasis of triple-negative breast cancer (TNBC), Cell Physiol. Biochem. 50 (2018) 1945-1963
    S. Y. Cheng, Y. C. Yang, K. L. Ting, etal., Lactate dehydrogenase downregulation mediates the inhibitory effect of diallyl trisulfide on proliferation, metastasis, and invasion in triple-negative breast cancer, Environ. Toxicol. 32 (2017) 1390-1398
    Y. Liu, P. Zhu, Y. Wang, etal., Antimetastatic therapies of the polysulfide diallyl trisulfide against triple-negative breast cancer (TNBC) via suppressing MMP2/9 by blocking NF-κB and ERK/MAPK signaling pathways, PLoS One 10 (2015) e0123781
    S. H. Kim, E. R. Hahm, K.B.Singh, Diallyl trisulfide inhibits leptin-induced oncogenic signaling in human breast cancer cells but fails to prevent chemically-induced luminal-type cancer in rats, J. Cancer Prev. 25 (2020) 1-12
    K. C. Lai, S. C. Hsu, J. S. Yang, Diallyl trisulfide inhibits migration, invasion and angiogenesis of human colon cancer HT-29 cells and umbilical vein endothelial cells, and suppresses murine xenograft tumour growth, J. Cell Mol. Med. 19 (2015) 474-484
    Q. Tao, C. Wu, R. Xu, etal., Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of glioma cells by inactivating Wnt/β-catenin signaling, Cell Tissue Res. 370 (2017) 379-390
    P. Sujatha, P. G. Anantharaju, P. M. Veeresh, Diallyl disulfide (DADS) retards the growth of breast cancer cells in vitro and in vivo through apoptosis induction, Biomed. Pharmacol. J. 10 (2017) 1619-1630
    W.H. Talib, Consumption of garlic and lemon aqueous extracts combination reduces tumor burden by angiogenesis inhibition, apoptosis induction, and immune system modulation, Nutrition 43-44 (2017) 89-97
    Y. P. Liu, Y. Zhao, Y. Y. Wang, Suppressive role of diallyl trisulfide in the activated platelet-mediated hematogenous metastasis of MDA-MB-231 human breast cancer cells, Int. J. Mol. Med. 39 (2017) 1516-1524
    D. Bauer, N. Redmon, E. Mazzio, Diallyl disulfide inhibits TNFα induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling, Cytokine 75 (2015) 117-126
    V. A. Kiesel, S. D. Stan, Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells, Biochem .Biophys. Res. Commun. 484 (2017) 833-838
    X. Li, Y. Meng, C. Xie, Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway, J. Cell. Biochem. 119 (2018) 4134-4141
    X. Jiang, X. Zhu, N. Liu, Diallyl trisulfide Inhibits growth of NCI-H460 in vitro and in vivo, and ameliorates cisplatin-induced oxidative injury in the treatment of lung carcinoma in xenograft mice, Int. J . Biol. Sci. 13 (2017) 167-178
    H. C. Wang, Y. L. Chu, S. C. Hsieh, etal., Diallyl trisulfide inhibits cell migration and invasion of human melanoma a375 cells via inhibiting integrin/facal adhesion kinase pathway, Environ. Toxicol. 32 (2017) 2352-2359
    A. K. Singh, A. Bishayee, A. K. Pandey, Targeting histone deacetylases with natural and synthetic agents: an emerging anticancer strategy, Nutrients 10 (2018)
    Y. M. Pan, S. Y. Lin, R. Xing, Epigenetic upregulation of metallothionein 2A by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel through attenuating NF-κB activation, Antioxid. Redox Signal. 24 (2016) 839-854
    S. Lin, X. Wang, Y. Pan, Transcription factor myeloid zinc-finger 1 suppresses human gastric carcinogenesis by interacting with metallothionein 2A, Clin .Cancer Res. 25 (2019) 1050-1062
    X. Xiao, B. Chen, X. Liu, Diallyl disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a, PLoS One 9 (2014) e112720
    Y. Li, J. Zhang, L. Zhang, etal., Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling, Carcinogenesis 34 (2013) 1601-1610
    E. P. Chiang, S. C. Chiu, M. H. Pai, Organosulfur garlic compounds induce neovasculogenesis in human endothelial progenitor cells through a modulation of MicroRNA 221 and the PI3-K/Akt signaling pathways, J. Agric. Food Chem. 61 (2013) 4839-4849
    Z. H. Wei, Y. L. Shan, L. Tao, Diallyl trisulfides, a natural histone deacetylase inhibitor, attenuate HIF-1α synthesis, and decreases breast cancer metastasis, Mol. Carcinog. 56 (2017) 2317-2331
    H. K. Na, E. H. Kim, M. A. Choi, Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1, Biochem. Pharmacol. 84 (2012) 1241-1250
    X. Xie, X. Huang, H. Tang, et al., Diallyl disulfide inhibits breast cancer stem cell progression and glucose metabolism by targeting CD44/PKM2/AMPK signaling, Curr. Cancer Drug Targets 18 (2018) 592–599
    S.H. Kim, C.H. Kaschula, N. Priedigkeit, et al., Forkhead box Q1 is a novel target of breast cancer stem cell inhibition by diallyl trisulfide, J. Biol. Chem. 291 (2016) 13495–13508
    A. Liskova, P. Kubatka, M. Samec, et al., Dietary phytochemicals targeting cancer stem cells, Molecules 24 (2019), 899
    Y. Qiao, X. Jiang, S. T. Lee, FOXQ1 regulates epithelial-mesenchymal transition in human cancers, Cancer Res. 71 (2011) 3076-3086
    H. Zhang, F. Meng, G. Liu, Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis, Cancer Res. 71 (2011) 1292-13301
    Y. Q. Chen, R. Xue, X. C. Jin, Antiarthritic activity of diallyl disulfide against freund's adjuvant-induced arthritic rat model, J. Environ. Pathol. Toxicol. Oncol. 37 (2018) 291-303
    N. Zhang, Y. L. Wang, J. L. Zhang, Diallyl disulfide attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, lipid peroxidation and inflammation in mice, Mol .Med. Rep. 20 (2019) 1363-1372
    C. Feng, Y. Luo, Y. Nian, Diallyl disulfide suppresses the inflammation and apoptosis resistance induced by DCA through ROS and the NF-κB signaling pathway in human barrett's epithelial cells, Inflammation 40 (2017) 818-831
    S. Miltonprabu, N. C. Sumedha, P. Senthilraja, Diallyl trisulfide, a garlic polysulfide protects against As-induced renal oxidative nephrotoxicity, apoptosis and inflammation in rats by activating the Nrf2/ARE signaling pathway, Int. Immunopharmacol. 50 (2017) 107-120
    H. H. Lee, J. W. Jeong, S. H. Hong, Diallyl trisulfide suppresses the production of lipopolysaccharide-induced inflammatory mediators in BV2 microglia by decreasing the NF-κB pathway activity associated with toll-like receptor 4 and CXCL12/CXCR4 pathway blockade, J. Cancer Prev. 23 (2018) 134-140
    J. Liu, W. Liu, H. Yang, Balancing apoptosis and autophagy for parkinson's disease therapy: targeting BCL-2, ACS Chem. Neurosci. 10 (2019) 792-802
    S. Nakamura, M. Izumi, Chlorophagy is ATG gene-dependent microautophagy process, Plant Signal. Behav. 14 (2019) 1554469
    L. Li, W. L. Liu, L. Su, The role of autophagy in cancer radiotherapy, Curr. Mol. Pharmacol. 13 (2020) 31-40
    T. Suangtamai, D. I. Tanyong, Diallyl disulfide induces apoptosis and autophagy via mTOR pathway in myeloid leukemic cell line, Tumour Biol. 37 (2016) 10993-10999
    Y. Y. Wu, Y. Q. Hu, H. Y. Zhou, Organosulfur compounds induce cytoprotective autophagy against apoptosis by inhibiting mTOR phosphorylation activity in macrophages, Acta Biochim. Biophys. Sin. 50 (2018) 1085-1093
    Z. Q. Yue, X. Guan, R. Chao, Diallyl disulfide induces apoptosis and autophagy in human osteosarcoma MG-63 cells through the PI3K/Akt/mTOR pathway, Molecules 24 (2019) E2665
    K. G. K. Deepak, R. Vempati, G. P. Nagaraju, Tumor microenvironment: Challenges and opportunities in targeting metastasis of triple negative breast cancer, Pharmacol . Res 153 (2020) 104683
    R. R. Malla, K. Deepak, N. Merchant, Breast Tumor Microenvironment: Emerging target of therapeutic phytochemicals, Phytomedicine 70 (2020) 153227
    N. Horn, G. Miller, K. M. Ajuwon, Garlic diallyl disulfide and diallyl trisulfide mitigates effects of pro-oxidant induced cellular stress and has immune modulatory function in LPS-stimulated porcine epithelial cells, J. Anim. Sci. 95 (2017) 4045-4051
    I. A. Schepetkin, L. N. Kirpotina, A. I. Khlebnikov, Neutrophil immunomodulatory activity of natural organosulfur compounds, Molecules 24 (2019) 1809
    Y. Hashizume, K. Shirato, I. Abe, Diallyl disulfide reduced dose-dependently the number of lymphocyte subsets and monocytes in rats, J. Nutr .Sci .Vitaminol. (Tokoyo) 58 (2012) 292-296
    M. Ebrahimi, Z. Mohammad Hassan, A. Mostafaie, Purified protein fraction of garlic extract modulates cellular immune response against breast transplanted tumors in BALB/c mice model, Cell J. 15 (2013) 65-75
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