Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics:Underlying risks and the emergence of ultrasmall nanomagnets

Divya S. Parimi; Yamini Gupta; Sreekar Marpu; Chandra S. Bhatt; Tharun K. Bollu; Anil K. Suresh

doi:10.1016/j.jpha.2021.11.002

Volume 12 Issue 3

Jun. 2022

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Article Navigation > Journal of Pharmaceutical Analysis > 2022 > 12(3): 365-379

Divya S. Parimi, Yamini Gupta, Sreekar Marpu, Chandra S. Bhatt, Tharun K. Bollu, Anil K. Suresh. Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics:Underlying risks and the emergence of ultrasmall nanomagnets[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 365-379. doi: 10.1016/j.jpha.2021.11.002

Citation:

Divya S. Parimi, Yamini Gupta, Sreekar Marpu, Chandra S. Bhatt, Tharun K. Bollu, Anil K. Suresh. Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics:Underlying risks and the emergence of ultrasmall nanomagnets[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 365-379. doi: 10.1016/j.jpha.2021.11.002

Citation:

Divya S. Parimi, Yamini Gupta, Sreekar Marpu, Chandra S. Bhatt, Tharun K. Bollu, Anil K. Suresh. Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics:Underlying risks and the emergence of ultrasmall nanomagnets[J]. Journal of Pharmaceutical Analysis, 2022, 12(3): 365-379. doi: 10.1016/j.jpha.2021.11.002

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Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics:Underlying risks and the emergence of ultrasmall nanomagnets

doi: 10.1016/j.jpha.2021.11.002

a. Bionanotechnology &Sustainable Laboratory, Department of Biological Sciences, School of Engineering and Applied Sciences, Sri Ramaswamy Memorial (SRM) University, Amaravati, 522503, India;
b. Department of Chemistry, University of North Texas, Denton, TX, 76201, USA;
c. Department of Biotechnology, Faculty of Science and Humanities, Sri Ramaswamy Memorial (SRM) Institute of Science and Technology, Chennai, 603203, India

Funds:

Anil K. Suresh would like to thank the Department of Biotechnology, Government of India, for financial support through Ramalinga Swami Fellowship Award, and the Science Education and Research Board, Department of Science and Technology, Government of India, New Delhi, for financial support through Early Career Research Award (Grant No.: ECR/2017/000339). The authors would like to thank Saptarshi Mazumder and Rajarshi Mazumder for making the 3-dimensional animations in the figures.

Received Date: May 26, 2021
Accepted Date: Nov. 04, 2021
Rev Recd Date: Oct. 21, 2021
Publish Date: Nov. 10, 2021

Abstract

Abstract

Cancer therapy is a fast-emerging biomedical paradigm that elevates the diagnostic and therapeutic potential of a nanovector for identification, monitoring, targeting, and post-treatment response analysis. Nanovectors of superparamagnetic iron oxide nanoparticles (SPION) are of tremendous significance in cancer therapy because of their inherited high surface area, high reactivity, biocompatibility, superior contrast, and magnetic and photo-inducibility properties. In addition to a brief introduction, we summarize various progressive aspects of nanomagnets pertaining to their production with an emphasis on sustainable biomimetic approaches. Post-synthesis particulate and surface alterations in terms of pharmaco-affinity, liquid accessibility, and biocompatibility to facilitate cancer therapy are highlighted. SPION parameters including particle contrast, core-fusions, surface area, reactivity, photosensitivity, photodynamics, and photothermal properties, which facilitate diverse cancer diagnostics, are discussed. We also elaborate on the concept of magnetism to selectively focus chemotherapeutics on tumors, cell sorting, purification of bioentities, and elimination of toxins. Finally, while addressing the toxicity of nanomaterials, the advent of ultrasmall nanomagnets as a healthier alternative with superior properties and compatible cellular interactions is reviewed. In summary, these discussions spotlight the versatility and integration of multi-tasking nanomagnets and ultrasmall nanomagnets for diverse cancer theragnostics.
- Nanomagnets,
- Biomimetics,
- Utrasmall-SPIONs,
- Magnetization,
- Core-fusion,
- Cancer theragnostics

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References(132)

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