Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging

Rui-Lin Liu; Ru-Qian Cai

doi:10.1016/j.jpha.2021.10.002

Volume 12 Issue 4

Sep. 2022

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Article Navigation > Journal of Pharmaceutical Analysis > 2022 > 12(4): 530-540

Rui-Lin Liu, Ru-Qian Cai. Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging[J]. Journal of Pharmaceutical Analysis, 2022, 12(4): 530-540. doi: 10.1016/j.jpha.2021.10.002

Citation:

Rui-Lin Liu, Ru-Qian Cai. Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging[J]. Journal of Pharmaceutical Analysis, 2022, 12(4): 530-540. doi: 10.1016/j.jpha.2021.10.002

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Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging

doi: 10.1016/j.jpha.2021.10.002

Rui-Lin Liu^{a,b
,
,},
Ru-Qian Cai^a

a. School of Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China;
b. Department of Pharmaceutical Analysis, School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China

Funds:

This review was supported by the National Natural Science Foundation of China (Grant No.: 81703466), the Outstanding Talents Research Start-up Fund of Xuzhou Medical University, China (Grant No.: RC20552107), and Xuzhou Science and Technology Bureau, China (Grant No.: KC21292).

Received Date: May 07, 2021
Accepted Date: Oct. 09, 2021
Rev Recd Date: Sep. 13, 2021
Publish Date: Oct. 11, 2021

Abstract

Abstract

Fluorescence imaging is a noninvasive and dynamic real-time imaging technique; however, it exhibits poor spatial resolution in centimeter-deep tissues because biological tissues are highly scattering media for optical radiation. The recently developed ultrasound-controlled fluorescence (UCF) imaging is a novel imaging technique that can overcome this bottleneck. Previous studies suggest that the effective contrast agent and sensitive imaging system are the two pivotal factors for generating high-resolution UCF images ex vivo and/or in vivo. Here, this review highlights the recent advances (2015-2020) in the design and synthesis of contrast agents and the improvement of imaging systems to realize high-resolution UCF imaging of deep tissues. The imaging performances of various UCF systems, including the signal-to-noise ratio, imaging resolution, and imaging depth, are specifically discussed. In addition, the challenges and prospects are highlighted. With continuously increasing research interest in this field and emerging multidisciplinary applications, UCF imaging with higher spatial resolution and larger imaging depth may be developed shortly, which is expected to have a far-reaching impact on disease surveillance and/or therapy.
- Ultrasound-controlled fluorescence imaging,
- Temperature-sensitive NIR probes,
- High-resolution,
- Deep tissue,
- Molecular diagnosis

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References(58)

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