Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its derivatives: Potential role in prevention and management of COVID-19

Souparnika H. Manjunath; Rajesh K. Thimmulappa

doi:10.1016/j.jpha.2021.09.009

Volume 12 Issue 1

Feb. 2022

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Souparnika H. Manjunath, Rajesh K. Thimmulappa. Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its derivatives: Potential role in prevention and management of COVID-19[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 29-34. doi: 10.1016/j.jpha.2021.09.009

Citation:

Souparnika H. Manjunath, Rajesh K. Thimmulappa. Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its derivatives: Potential role in prevention and management of COVID-19[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 29-34. doi: 10.1016/j.jpha.2021.09.009

Citation:

Souparnika H. Manjunath, Rajesh K. Thimmulappa. Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its derivatives: Potential role in prevention and management of COVID-19[J]. Journal of Pharmaceutical Analysis, 2022, 12(1): 29-34. doi: 10.1016/j.jpha.2021.09.009

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Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its derivatives: Potential role in prevention and management of COVID-19

doi: 10.1016/j.jpha.2021.09.009

Department of Biochemistry, Jagadguru Sri Shivarathreeshwara Medical College, Jagadguru Sri Shivarathreeshwara Academy of Higher Education & Research (JSSAHER), Mysore, 570015, India

Funds:

Rajesh Kumar Thimmulappa acknowledges the funding support from the Department of Biotechnology, Ramalingaswami Re-entry Fellowship (Grant No.: BT/RLF/Re-entry/37/2013) and the Department of Science and Technology grant (Grant No.: DST/INT/SOUTH AFRICA/P13/2016).

Received Date: Apr. 19, 2021
Accepted Date: Sep. 16, 2021
Rev Recd Date: Sep. 08, 2021
Publish Date: Sep. 20, 2021

Abstract

Abstract

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused a devastating health crisis worldwide. In this review, we have discussed that prophylactic phytochemical quercetin supplementation in the form of foods or nutraceuticals may help manage the COVID-19 pandemic. The following evidence supports our argument. First, nuclear factor erythroid-derived 2-like 2 (NRF2) agonists abrogate replication of SARS-CoV-2 in lung cells, and quercetin is a potent NRF2 agonist. Second, quercetin exerts antiviral activity against several zoonotic coronaviruses, including SARS-CoV-2, mainly by inhibiting the entry of virions into host cells. Third, inflammatory pathways activated by nuclear factor kappa B, inflammasome, and interleukin-6 signals elicit cytokine release syndrome that promotes acute respiratory distress syndrome in patients with COVID-19, and quercetin inhibits these pro-inflammatory signals. Fourth, patients with COVID-19 develop thrombosis, and quercetin mitigates coagulation abnormalities by inhibiting plasma protein disulfide isomerase. This review provides a strong rationale for testing quercetin for the management of COVID-19.
- COVID-19,
- Quercetin,
- Immunomodulation,
- Cytokine response syndrome,
- NRF2,
- Antiviral

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References(69)

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